pyrazoles-derivatives

A Facile C-H Insertion Strategy using Combination of HFIP and Isocyanides: Metal-Free Access to Azole Derivatives was written by Gujjarappa, Raghuram;Vodnala, Nagaraju;Reddy, Velma Ganga;Malakar, Chandi C.. And the article was included in Asian Journal of Organic Chemistry in 2020.Formula: C8H7NO2 This article mentions the following:

An efficient metal-free approach has been devised towards the synthesis of azoles via C-H insertion protocol. Various isocyanides were examined as effective C1-synthons. The HFIP plays crucial role as hydrogen source and promoter of the reaction in order to reveal the maximum efficacies to accomplish the transformation in high yields of the products with excellent functional group tolerance. The control experiment affirmed 83% of deuterium incorporation, when the reaction was performed using HFIP-d₂. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Formula: C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Formula: C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Phosphine-Catalyzed Dearomative [3 + 2] Cycloaddition of Benzoxazoles with a Cyclopropenone was written by Wang, Xingben;Yu, Congjun;Atodiresei, Iuliana L.;Patureau, Frederic W.. And the article was included in Organic Letters in 2022.COA of Formula: C8H7NO2 This article mentions the following:

The triphenylphosphine catalyzed dearomative [3+2] cycloaddition of benzoxazoles I (R = H, F, Ph, Me, etc.; R¹ = H, Me, F, Cl, Br, Et; RR¹ = -CH=CH-CH=CH-; R² = H, Me, F, Cl) with 1,2-diphenylcyclopropenone II (Ar = Ph, 3-methylphenyl) were described. The reaction scope, mechanism and possible future applications of this rare organocatalyzed cycloaddition were discussed. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3COA of Formula: C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.COA of Formula: C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A density functional study on the efficiencies of 2-mercaptobenzoxazole and its derivatives as chelating agents in flotation processes was written by Yekeler, Meftuni;Yekeler, Huelya. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2006.Electric Literature of C8H7NOS This article mentions the following:

By using the d. functional theory (DFT), we calculated some properties such as the energies of HOMO orbitals and the at. charges which are related to the reactive behavior of 2-mercaptobenzoxazole (MBO) and its Me and methoxy derivatives The results of the calculations indicated that the efficiencies of MBO and its derivatives depend on the investigated parameters, and 2-mercaptobenzothiazole (MBT) is better than MBO as a collector agent. Electron donating groups at the 6-position of MBO provided the best efficiency for MBO mol. The introduction of the Me group to any position of the benzene ring makes also MBO more powerful chelating agent by increasing the at. charges on the N and S atoms. The theor. obtained results are consistent with the exptl. data reported in the literature. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Electric Literature of C8H7NOS).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Electric Literature of C8H7NOS

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Formal Carbene C-H Bond Insertion in the Cu(I)-Catalyzed Reaction of Bis(trimethylsilyl)diazomethane with Benzoxazoles and Oxazoles was written by Wang, Shuai;Xu, Shuai;Yang, Cheng;Sun, Hanli;Wang, Jianbo. And the article was included in Organic Letters in 2019.Category: benzoxazole This article mentions the following:

A Cu(I)-catalyzed cross-coupling reaction of bis(trimethylsilyl)diazomethane and benzoxazoles/oxazoles is reported. A wide range of functional groups can be tolerated in this transformation. This reaction provides a new method to directly introduce a 1,1-bis(trimethylsilyl)methyl group into heteroaromatic C-H bonds. Subsequent transformations of 1,1-bis(trimethylsilyl)-methylated heteroaromatic compounds are also presented. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Category: benzoxazole).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Copper-Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates was written by Antuganov, Dmitrii;Zykov, Michail;Timofeev, Vasilii;Timofeeva, Ksenija;Antuganova, Yulija;Orlovskaya, Victoriya;Fedorova, Olga;Krasikova, Raisa. And the article was included in European Journal of Organic Chemistry in 2019.Application of 936902-12-4 This article mentions the following:

Radiofluorination of arylboronic acids pinacol esters (arylBPin) mediated by copper triflate pyridine complex is one of the more promising synthetic approaches for the direct introduction of nucleophilic [¹⁸F]fluoride into non-activated arenes and heteroarenes. However, the application of this method to the production of positron emission tomog. (PET) radiotracers in automated synthesizers remains a challenging task. The choice of phase-transfer catalyst (PTC) and corresponding base used for the generation of reactive [¹⁸F]fluoride species has a profound impact on the efficiency of the ¹⁸F-fluorination process. Herein the authors report the development of a simple procedure involving trapping of the aqueous [¹⁸F]fluoride on a weak anion-exchange resin (WAX) and its release by elution with pyridinium sulfonate in di-Me acetamide. Obtained reactive [¹⁸F]fluoride was used as-is in a copper-catalyzed fluorination reaction employing pyridinium salt as both PTC and base. High radiochem. conversion rates (RCCs) achieved for a series of simple arylBPin substrates and 4-[¹⁸F]fluoro-D,L-phenylalanine demonstrate the efficiency of this novel ¹⁸F-processing approach. Notably, the proposed method obviates conventional azeotropic drying steps, solvents evaporation and/or changeover and can be implemented on com. automated synthesizers. In the experiment, the researchers used many compounds, for example, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (cas: 936902-12-4Application of 936902-12-4).

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (cas: 936902-12-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Application of 936902-12-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Sulfenylation of β-Diketones Using C-H Functionalization Strategy was written by Varun, Begur Vasanthkumar;Gadde, Karthik;Prabhu, Kandikere Ramaiah. And the article was included in Organic Letters in 2015.Reference of 23417-29-0 This article mentions the following:

Sulfenylation of β-diketones is challenging as β-diketones undergo deacylation after sulfenylation in the reaction medium. The sulfenylation of β-diketones without deacylation under metal-free conditions at ambient temperature via a cross dehydrogenative coupling (CDC) strategy is reported. The resultant products can be further manipulated to form α,α-disubstituted β-diketones and pyrazoles. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Reference of 23417-29-0).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Reference of 23417-29-0

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem