Tag: M.W:100-200

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride( cas:22600-77-7 ) is researched.Computed Properties of C4H9Cl2N3.Casagrande, Manolo; Barteselli, Anna; Basilico, Nicoletta; Parapini, Silvia; Taramelli, Donatella; Sparatore, Anna published the article 《Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline》 about this compound( cas:22600-77-7 ) in Bioorganic & Medicinal Chemistry. Keywords: quinoline heteroarylmethylamino heteroarylamino preparation antiplasmodial activity; antimalarial aminoquinoline chloro preparation. Let’s learn more about this compound (cas:22600-77-7).

With the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-4-(heteroarylmethylamino)quinoline and 7-chloro-4-(heteroarylamino)quinoline derivatives was synthesized and tested in vitro against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum. All compounds exhibited from moderate to high antiplasmodial activities. The activity was strongly influenced both by the presence of a methylenic group, as a spacer between the 4-aminoquinoline and the heterocyclic ring, and by the presence of a basic head. The most potent mols. inhibited the growth of both CQ-S and CQ-R strains of P. falciparum with IC50 < 30 nM and were not toxic against human endothelial cells. These results confirm that the presence of an heteroaryl moiety in the side chain of 7-chloro-4-aminoquinoline is useful for the design and development of new powerful antimalarial agents. This compound((1H-Imidazol-2-yl)methanamine dihydrochloride)Computed Properties of C4H9Cl2N3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments, published in 2002-09-20, which mentions a compound: 22600-77-7, mainly applied to azathiaalkaneone azidofluorophenyl functionalized preparation; rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex preparation photolysis amine; human serum albumin labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex; antibody labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex, Computed Properties of C4H9Cl2N3.

Functionalization of perfluoro aryl azides by bifunctional chelating agents (BFCAs) capable of forming high specific activity complexes with 99mTc (for γ-imaging) and 188Re (for radiotherapy) is described. The synthesis of multidonor BFCAs containing N2S2, N4, and N3S donor groups containing imidazole, pyridine, and pyrazine functionalities that may be important for tuning the pharmacokinetic parameters is also described. Functionalization of perfluoro aryl azides at various sites on BFCAs yields novel bifunctional photolabile chelating agents (BFPCAs) that are useful for covalent attachment to biomols. A representative Re-BFPCA I as the Me4N+ salt in a model solvent, diethylamine, proceeded to give a high yield of intermol. NH insertion product without the decomplexation of the metal ion from I. All products originated from the photolysis of I in diethylamine were characterized by anal. techniques, and a plausible mechanism of formation of different photolytic products is suggested. The high yield of intermol. NH insertion of I is extended to labeling of human serum albumin (HSA) and Fab fragments under aqueous conditions. The photolabeling technol. developed here offers a new way to attach diagnostically and therapeutically useful radiotracers (e.g., 99mTc, 188Re) to Fab fragments for potential noninvasive imaging and therapy of cancer.

《Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((1H-Imidazol-2-yl)methanamine dihydrochloride)Computed Properties of C4H9Cl2N3.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 4-Fluoro-1H-indole-3-carboxylic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Fluoro-1H-indole-3-carboxylic acid, is researched, Molecular C9H6FNO2, CAS is 23077-42-1, about Synthesis of cyclic chiral α-amino boronates by copper-catalyzed asymmetric dearomative borylation of indoles. Author is Chen, Lili; Shen, Jun-Jian; Gao, Qian; Xu, Senmiao.

A copper(I)-catalyzed dearomative borylation of N-alkoxycarbonyl protected indole-3-carboxylates has been developed. The boron addition in this reaction occurred regioselectively at the 2-position of indoles followed by diastereoselective protonation, affording the corresponding stable cyclic chiral α-amino boronates (2-borylindolines) in moderate to good yields with excellent diastereo- and enantioselectivities. The product 2c could be used as a versatile precursor to undergo subsequent stereoselective transformations, delivering highly functionalized 2,3,3-trisubstituted chiral indolines.

《Synthesis of cyclic chiral α-amino boronates by copper-catalyzed asymmetric dearomative borylation of indoles》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(4-Fluoro-1H-indole-3-carboxylic acid)Application In Synthesis of 4-Fluoro-1H-indole-3-carboxylic acid.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 17190-29-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about P(i-PrNCH2CH2)3N as a Lewis Base Catalyst for the Synthesis of β-Hydroxynitriles Using TMSAN. Author is Wadhwa, Kuldeep; Verkade, John G..

The title proazaphosphatrane was found to be an efficient catalyst for synthesis of β-hydroxynitriles via the reaction of trimethylsilylacetonitrile (TMSAN) with aldehydes under mild reaction conditions and typically low catalyst loading (ca. 2 mol %). A variety of functional groups were tolerated, and good to excellent product yields were obtained.

《P(i-PrNCH2CH2)3N as a Lewis Base Catalyst for the Synthesis of β-Hydroxynitriles Using TMSAN》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Product Details of 17190-29-3.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kawano, Yoshikazu; Kaneko, Nobuya; Mukaiyama, Teruaki published the article 《Lewis base-catalyzed cyanomethylation of carbonyl compounds with (trimethylsilyl)acetonitrile》. Keywords: Lewis base catalyzed cyanomethylation carbonyl compound trimethylsilyl acetonitrile; lithium acetate catalyzed cyanomethylation carbonyl compound silyl acetonitrile.They researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Category: pyrazoles-derivatives. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17190-29-3) here.

Catalytic cyanomethylation of various carbonyl compounds with (trimethylsilyl)acetonitrile (TMSCH2CN) in the presence of Lewis bases such as cesium or lithium acetate proceeded smoothly to afford the corresponding cyanomethylated adducts in good yields. Thus, AcOLi catalyzed cyanomethylation of PhCHO with Me3SiCH2CN in DMF at 0° to room temperature followed by acid hydrolysis gave 98% PhCHOHCH2CN.

《Lewis base-catalyzed cyanomethylation of carbonyl compounds with (trimethylsilyl)acetonitrile》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Category: pyrazoles-derivatives.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Formula: C9H9NO.Koenig, Thomas M.; Mitchell, David published the article 《A convenient method for preparing enantiomerically pure norfluoxetine, fluoxetine and tomoxetine》 about this compound( cas:17190-29-3 ) in Tetrahedron Letters. Keywords: norfluoxetine enantiomeric preparation; fluoxetine enantiomeric preparation; tomoxetine enantiomeric preparation. Let’s learn more about this compound (cas:17190-29-3).

A convenient synthesis for enantiomers of norfluoxetine (I; R = 4-F3C, R1 = H), fluoxetine (I; R = F3C, R1 = Me) and tomoxetine (I: R = R1 = Me) is described. All final products were derived from 3-phenyl-3-hydroxypropylamine, prepared in 2 steps from PhCHO and acetonitrile.

This compound(3-Hydroxy-3-phenylpropanenitrile)Formula: C9H9NO was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about P(RNCH2CH2)3N-Catalyzed Synthesis of β-Hydroxy Nitriles, the main research direction is proazaphosphatrane catalyst reaction nitrile aldehyde ketone; hydroxy nitrile preparation.Product Details of 17190-29-3.

Successful synthesis of β-hydroxy nitriles in very good to excellent yields from aldehydes and ketones in a simple reaction that is promoted by strong nonionic bases of the title type is reported. The reaction occurs in the presence of magnesium salts which activate the carbonyl group and stabilizes the enolate thus produced. E.g., reaction of MeCN with acetone in presence of a proazaphosphatrane and MgSO4 gave 94% HOCMe2CH2CN.

This compound(3-Hydroxy-3-phenylpropanenitrile)Product Details of 17190-29-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Huang, Yaozeng; Liao, Yi researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Application of 17190-29-3.They published the article 《Synthetic applications of elementoorganic compounds of group 15 and 16. 85. Pentaalkyl stiboranes. 1. Synthesis of homobenzylic alcohols, homoallylic alcohols, homoallylic alcohols, ethyl 5-aryl-5-hydroxy-2-pentenoates, and β-hydroxypropionic acid derivatives via pentaalkylstiboranes》 about this compound( cas:17190-29-3 ) in Journal of Organic Chemistry. Keywords: stiborane alkyl preparation reaction aldehyde; alc homobenzylic homoallylic; pentenoate hydroxy; aldehyde aromatic reaction pentaalkylstiborane. We’ll tell you more about this compound (cas:17190-29-3).

Although pentaalkylstiboranes have long been known, their applications in organic synthesis have not been exploited. Treating [Bu3SbCH2E]+ X- (E = Ph, vinyl, CH:CHCO2Et, CO2Et, cyano; X = Br, iodo, BPh4) with RLi (R = Bu, Me3C, Ph) give pentaalkylstiboranes, Bu3Sb(R)CH2E, which react with aromatic aldehydes to give, after subsequent hydrolysis, homobenzylic and homoallylic alcs., Et 5-aryl-5-hydroxy-2-pentenoates, Et β-aryl-β-hydroxypropionates, and β-aryl-β-hydroxypropionitriles, resp., in good-to-excellent yields. The reaction is chemoselective for aldehydes.

This compound(3-Hydroxy-3-phenylpropanenitrile)Application of 17190-29-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of C9H9NO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about A new facile chemoenzymatic synthesis of levamisole.

An efficient and facile chemoenzymic synthesis of levamisole by employing lipase-mediated resolution of 3-hydroxy-3-(phenyl)propanenitrile followed by its conversion to β-amino alc. as the key intermediate is described. The resolution of β-(acetyloxy)benzenepropanenitrile using diatomite-immobilized Pseudomonas cepacia (Burkholderia cepacia) lipase gave (+)-(βR)-β-(hydroxy)benzenepropanenitrile. The resolution of β-(hydroxy)benzenepropanenitrile using immobilized lipase gave (βR)-β-(acetyloxy)benzenepropanenitrile. Both intermediates were used for the synthesis of (6S)-2,3,5,6-tetrahydro-6-(phenyl)imidazo[2,1-b]thiazole (levamisole).

Different reactions of this compound(3-Hydroxy-3-phenylpropanenitrile)Synthetic Route of C9H9NO require different conditions, so the reaction conditions are very important.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang published the article 《Nitrile biotransformations for the synthesis of enantiomerically enriched β2-, and β3-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity》 about this compound( cas:17190-29-3 ) in Tetrahedron: Asymmetry. Keywords: Rhodococcus nitrile hydratase biotransformation enantiomeric. Let’s learn more about this compound (cas:17190-29-3).

Rhodococcus erythropolis AJ270, a nitrile hydratase/amidase-containing microbial whole cell catalyst, is able to catalyze the hydrolysis of a number of β-hydroxy and β-alkoxy nitriles under very mild conditions. Both the efficiency and enantioselectivity of the biocatalysis, however, were strongly dependent upon the structures of both nitrile and amide substrates. When biotransformations of racemic 3-hydroxy-3-phenylpropionitrile and 2-hydroxymethyl-3-phenylpropionitrile gave low enantioselectivity, their O-methylated isomers underwent highly efficient and enantioselective biocatalytic reactions to afford highly enantioenriched β2- and β3-hydroxy amide and acid derivatives in excellent yield. The study has provided an example of simple and very convenient substrate engineering method to increase the enantioselectivity of the biocatalytic reaction.

《Nitrile biotransformations for the synthesis of enantiomerically enriched β2-, and β3-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics