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Application of 1300746-79-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about A Concise Synthesis of Asymmetrically 4,5-Disubstituted 9,9-Dimethyl-9H-xanthenes. Author is Matsubara, Ryosuke; Koide, Miki; Shin, Yong-Soon; Shimada, Toshiyuki; Hayashi, Masahiko.

A concise synthesis of asym. 4,5-disubstituted 9,9-dimethyl-9H-xanthenes was developed. The monolithiation of 4,5-dibromo-9H-xanthene, subsequent zincation, and the Negishi coupling with diverse electrophiles afforded the corresponding 4-aryl- or 4-vinyl-9H-xanthenes in good yields and with high selectivity. The second substitution reactions were performed under mild reaction conditions, thus providing a convenient synthetic route to functionalized mols. based on the 9H-xanthene skeleton.

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Name: (1,10-Phenanthroline)(trifluoromethyl)copper(I). So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about CuO-catalyzed conversion of arylacetic acids into aromatic nitriles with K4Fe(CN)6 as the nitrogen source.

CuO was demonstrated to be effective as the catalyst for the conversion of arylacetic acids to aromatic nitriles ArCN [Ar = Ph, 2-MeC6H4, 1-naphthyl, etc.] with non-toxic and inexpensive K4Fe(CN)6 as the nitrogen source via the complete cleavage of the C≡N triple bond. The present method allowed a series of arylacetic acids including phenylacetic acids, naphthaleneacetic acids, 2-thiopheneacetic acid and 2-furanacetic acid to be converted into the targeted products in low to high yields.

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Application of 1300746-79-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Interrupting the Barton-McCombie Reaction: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates. Author is Liu, Zhi-Yun; Cook, Silas P..

The site-selective trifluoromethylation of aliphatic systems remains an important challenge. A light-driven, copper-mediated trifluoromethylation of O-alkyl thiocarbonates was described for the synthesis of trifluoromethyl-alkanes. The reaction provided broad functional group tolerance (e.g., alkyne, alkene, phenol, free alcs., electron-rich and -deficient arenes), thereby offering orthogonality and practicality for trifluoromethylation. A radical organometallic mechanism was proposed.

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Computed Properties of C13H8CuF3N2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Trifluoromethylation of Arylsilanes with [(phen)CuCF3]. Author is Morstein, Johannes; Hou, Haiyun; Cheng, Chen; Hartwig, John F..

A method for the trifluoromethylation of arylsilanes is reported. The reaction proceeds with [(phen)CuCF3] as the CF3 source under mild, oxidative conditions with high functional-group compatibility. This transformation complements prior trifluoromethylation of arenes in several ways. Most important, this method converts arylsilanes formed by the silylation of aryl C-H bonds to trifluoromethylarenes, thereby allowing the conversion of arenes to trifluoromethylarenes. The unique capabilities of the reported method are demonstrated by the conversion of a C-H bond into a C-CF3 bond in active pharmaceutical ingredients which do not undergo this overall transformation by alternative functionalization processes, including a combination of borylation and trifluoromethylation.

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Pyrazole – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)(SMILESS: F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F,cas:1300746-79-5) is researched.HPLC of Formula: 17190-29-3. The article 《Radical Anions of Trifluoromethylated Perylene and Naphthalene Imide and Diimide Electron Acceptors》 in relation to this compound, is published in Organic Letters. Let’s take a look at the latest research on this compound (cas:1300746-79-5).

A series of electron-deficient perylene and naphthalene imides and diimides with varying degrees of trifluoromethylation were synthesized. Single crystal X-ray anal. afforded detailed structural information, while spectroelectrochem. and EPR spectroscopy provided characterization of the radical anions . This study reveals that trifluoromethylation of the imides and diimides makes their one-electron reduction potentials substantially more pos. relative to the unsubstituted counterparts, while their other properties remain largely unchanged.

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Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1300746-79-5, is researched, SMILESS is F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F, Molecular C13H8CuF3N2Journal, Article, Beilstein Journal of Organic Chemistry called Comparative profiling of well-defined copper reagents and precursors for the trifluoromethylation of aryl iodides, Author is Kaplan, Peter T.; Lloyd, Jessica A.; Chin, Mason T.; Vicic, David A., the main research direction is aryltrifluoromethyl preparation; aryl iodide copper reagent trifluoromethylation; benchmarking; copper; fluorine; fluoroalkylation; trifluoromethylation.Name: (1,10-Phenanthroline)(trifluoromethyl)copper(I).

A number of copper reagents e.g., I were compared for their effectiveness in trifluoromethylating 4-iodobiphenyl, 4-iodotoluene, and 2-iodotoluene. Yields over time were plotted in order to refine our understanding of each reagent performance, identify any bottlenecks, and provide more insight into the rates of the reactions. Interestingly, differences in reactivity were observed when a well defined [LCuCF3] complex I was employed directly or generated in situ from precursors by published reports. Relative reactivities were also found to highly dependent on the nature of the iodoarenes.

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Kitson, Russell R. A.; Moody, Christopher J. published an article about the compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)( cas:1300746-79-5,SMILESS:F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F ).Electric Literature of C13H8CuF3N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1300746-79-5) through the article.

The toxicity associated with the geldanamycin (I) family of benzoquinone ansamycins when used as heat shock protein-90 inhibitor mol. therapeutics is ameliorated by substitution at the 19-position. The resulting 19-substituted derivatives have greater potential for success in oncol. clin. trials and for other medicinal purposes such as the treatment of neurodegenerative conditions. Having overcome hurdles associated with the sensitivity and complexity of these mols., through a variety of synthetic approaches, the synthesis of a series of 19-substituted geldanamycin derivatives is reported herein using optimized Stille and Suzuki coupling reactions. Further compounds were accessible via copper-mediated coupling and nucleophilic addition reactions. He new compounds are of significant medicinal interest, in view of their significantly reduced toxicity previously observed for this class of substrate compared to their 19-unsubstituted counterparts that have been evaluated in the clinic.

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Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of C13H8CuF3N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Computational characterization of a mechanism for the copper-catalyzed aerobic oxidative trifluoromethylation of terminal alkynes. Author is Jover, Jesus; Maseras, Feliu.

A reaction mechanism for the copper(i)-catalyzed oxidative aerobic trifluoromethylation of terminal alkynes has been determined by DFT calculations The transmetalation of CF-3 to copper appears to be a ligand replacement process independent of the metal. The dioxygen activation follows the sequence η1-superoxocopper(ii), μ-η2:η2-peroxodicopper(ii) and bis(μ-oxo)-dicopper(iii).

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Pyrazole – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1300746-79-5, is researched, Molecular C13H8CuF3N2, about Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues, the main research direction is aryl methyl ether fluoroalkyl preparation; phenol fluoroalkyl preparation; dextromethorphan fluoroalkyl fluoroalkoxy analog preparation.Safety of (1,10-Phenanthroline)(trifluoromethyl)copper(I).

We report the conversion of aryl Me ethers and phenols into six fluoroalkyl analogs I (R = OCF3, OCF2H, CF3, CF2H, CF2CF3, CF2Me) through late-stage functionalization of a natural product-derived FDA-approved therapeutic. This series of short synthetic sequences exploits a combination of both modern and traditional methods and demonstrates that some recently reported methods do not always work as well as desired on a natural product-like scaffold. Nonetheless, reaction optimization can deliver sufficient quantities of each target analog for medicinal chem. purposes. In some cases, classical reactions and synthetic sequences still out-compete modern organofluorine transformations, which should encourage the continued search for improved reactions. Overall, the project provides a valuable synthetic road map for medicinal chemists to access a range of fluorinated therapeutic candidates with distinct physicochem. properties relative to the original O-based analog.

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Pyrazole – Wikipedia,
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Computed Properties of C13H8CuF3N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about A General Strategy for the Perfluoroalkylation of Arenes and Arylbromides by Using Arylboronate Esters and [(phen)CuRF]. Author is Litvinas, Nichole D.; Fier, Patrick S.; Hartwig, John F..

A versatile method for the synthesis of aryl perfluoroalkanes from arenes and aryl bromides is described. Substituted arenes or aryl bromides are converted in situ to aryl boronate esters that readily undergo perfluoroalkylation in air with [(phen)CuRF]. A broad range of aryl bromide substrates was perfluoroalkylated in good yield for the first time. [(Phen)CuCF3] is now com. available and has been prepared on 20 g scale.

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Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics