Tag: M.W:100-200

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Azizi, Najmedin; Rahimi, Zahra; Alipour, Masoumeh researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Name: 3-Hydroxy-3-phenylpropanenitrile.They published the article 《A magnetic nanoparticle catalyzed eco-friendly synthesis of cyanohydrins in a deep eutectic solvent》 about this compound( cas:17190-29-3 ) in RSC Advances. Keywords: magnetic iron oxide catalyst aldehyde epoxide cyanation green chem. We’ll tell you more about this compound (cas:17190-29-3).

Magnetic Fe3O4 nanoparticles in deep eutectic solvents (DESs) have been regard as excellent catalysts for highly efficient cyanosilylation of various aldehydes and epoxides using trimethylsilyl cyanide TMSCN in high yields with excellent selectivity. Fe3O4 nanoparticles were synthesized and applied as a catalyst for the preparation of a wide variety of cyanohydrins (α-hydroxy nitriles and β-hydroxy nitriles) in readily available urea-choline chloride deep eutectic solvent DES as the most promising environmentally benign and cost-effective green solvent. Magnetic DES operates at very mild reaction conditions and can be easily recycled without significant loss of its catalytic activity.

《A magnetic nanoparticle catalyzed eco-friendly synthesis of cyanohydrins in a deep eutectic solvent》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Name: 3-Hydroxy-3-phenylpropanenitrile.

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COA of Formula: C5H5Cl2N3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-4,6-dichloro-5-methylpyrimidine, is researched, Molecular C5H5Cl2N3, CAS is 7153-13-1, about Synthesis and structure-activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production. Author is Jansa, Petr; Holy, Antonin; Dracinsky, Martin; Kolman, Viktor; Janeba, Zlatko; Kmonickova, Eva; Zidek, Zdenek.

Based on the previous discovery of the inhibitory effect of the 5-substituted 2-amino-4,6-dichloropyrimidines on nitric oxide (NO) production in vitro, a series of novel pyrimidine derivatives, namely 4,6-dichloro-2-[(N,N-dimethylamino)methyleneamino]pyrimidines, 2,4-diamino-6-chloropyrimidines, and 2,4-diamino-6-(2-hydroxyethoxy)pyrimidines, were prepared bearing various substituents at the C-5 position on the pyrimidine, such as hydrogen, Me, Et, Pr, iso-Pr, propargyl, allyl, Bu, sec-Bu, Ph, benzyl, and fluorine. The intrinsic biol. potential of the prepared compounds was characterized by effects on the in vitro production of immune-activated NO in mouse peritoneal cells. All 5-substituted 4,6-dichloro-2-[(N,N-dimethylamino)methyleneamino]pyrimidines strongly inhibited NO production The IC50s were <5 μM in most cases. The highest inhibitory activity was observed for the 5-s-Bu analog (IC50 = 2.57 μM), the lowest one for 5-unsubstituted compound (IC50 = 11.49 μM). With the exception of the 5-fluoro-4,6-dichloro-2-[(N,N-dimethylamino)methyleneamino] derivative, all other compounds were devoid of cytotoxic effects. The hitherto obtained data suggest that the NO-inhibitory activity depends on the presence of the 2-amino-4,6-dichloropyrimidine scaffold. 《Synthesis and structure-activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2-Amino-4,6-dichloro-5-methylpyrimidine)COA of Formula: C5H5Cl2N3.

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Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about A high throughput screening strategy for the assessment of nitrile-hydrolyzing activity towards the production of enantiopure β-hydroxy acids. Author is Coady, Tracey M.; Coffey, Lee V.; O’Reilly, Catherine; Owens, Erica B.; Lennon, Claire M..

Nitrile hydrolyzing enzymes have found wide use in the pharmaceutical industry for the production of fine chems. This work presents a strategy that facilitates the rapid identification of bacterial isolates demonstrating nitrile hydrolyzing activity. The strategy incorporates toxicity, starvation and induction studies along with subsequent colorimetric screening for activity, further focusing the assessment towards the substrates of interest. This high-throughput strategy uses a 96 well plate system, and has enabled the rapid biocatalytic screening of 256 novel bacterial isolates towards β-hydroxynitriles. Results demonstrate the strategy’s potential to rapidly assess a variety of β-hydroxynitriles including aliphatic, aromatic and dinitriles. A whole cell catalyst Rhodococcus erythropolis SET1 was identified and found to catalyze the hydrolysis of 3-hydroxybutyronitrile with remarkably high enantioselectivity under mild conditions, to afford (S)-3-hydroxybutyric acid in 42% yield and >99.9% ee. The biocatalytic capability of this strain including the variation of parameters such as temperature and time were further investigated and all results indicate the presence of a highly enantioselective if not enantiospecific nitrilase enzyme within the microbial whole cell.

《A high throughput screening strategy for the assessment of nitrile-hydrolyzing activity towards the production of enantiopure β-hydroxy acids》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Walther, Martin; Matterna, Madlen; Juran, Stefanie; Faehnemann, Silke; Stephan, Holger; Kraus, Werner; Emmerling, Franziska published the article 《Imidazole-containing bispidine ligands: synthesis, structure and Cu(II) complexation》. Keywords: copper imidazole bispidine complex preparation crystal structure.They researched the compound: (1H-Imidazol-2-yl)methanamine dihydrochloride( cas:22600-77-7 ).Category: pyrazoles-derivatives. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:22600-77-7) here.

The preparation and characterization of tris-pyridyl bispidine (3,7-diazabicyclo[3.3.1]nonane) derivatives with benzimidazole and imidazole donor groups at the N-3 position of the bispidine skeleton and their copper(II) complexes are reported. The impact of the hetaryl substituents on the configurational isomerism of piperidones and their corresponding bispidones was studied by NMR spectroscopy, revealing the exclusive appearance in the enol form for the piperidones in solution and the trans-configuration regarding the two pyridyl substituents, as well as the sole formation of the unsym. exo-endo isomers for the corresponding bispidones. Thus, the bispidones are preorganized ligands for building pentacoordinated complexes, confirmed by the preparation and characterization of the corresponding Cu(II) complexes. Of the di-pyridyl piperidones with benzimidazole and imidazole substituents, and of the Cu(II) complex of the benzimidazole-containing bispidone, crystals have become available for the anal. by x-ray diffraction, showing that the piperidones form the enol tautomers also in the solid state.

After consulting a lot of data, we found that this compound(22600-77-7)Category: pyrazoles-derivatives can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 17190-29-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Efficient lipase-catalyzed kinetic resolution and dynamic kinetic resolution of β-hydroxy nitriles. A route to useful precursors for γ-amino alcohols. Author is Pamies, Oscar; Backvall, Jan-E..

An efficient kinetic resolution of racemic β-hydroxy nitriles was performed via Candida antarctica lipase (N-435)-catalyzed transesterification. A variety of racemic alkyl, aryl, and aryloxymethyl substituted β-hydroxy nitriles was efficiently transformed to the corresponding enantiomerically pure acetates (ee >99% and conversion = 50%) with E values from 40 to >1000. The combination of the enzymic kinetic resolution with a ruthenium-catalyzed alc. racemization led to a dynamic kinetic resolution (ee’s up to 99%, yields up to 85%).

After consulting a lot of data, we found that this compound(17190-29-3)HPLC of Formula: 17190-29-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kolman, Viktor; Kalcic, Filip; Jansa, Petr; Zidek, Zdenek; Janeba, Zlatko published the article 《Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production》. Keywords: pyrimidine preparation SAR prostaglandin E2 inhibitor; Inhibitor; Prostaglandin E(2); Pyrimidines; Suzuki-Miyaura reaction.They researched the compound: 2-Amino-4,6-dichloro-5-methylpyrimidine( cas:7153-13-1 ).Recommanded Product: 7153-13-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7153-13-1) here.

As a part of a broader structure-activity relationship study of substituted 2-aminopyrimidines, the influence of the C-5 substitution on inhibition of prostaglandin E2 (PGE2) production was studied. Thirty compounds were prepared starting from the corresponding 2-amino-4,6-dichloropyrimidines using Suzuki cross-coupling. It was shown previously that 2-amino-4,6-dichloropyrimidines with smaller C-5 substituent (hydrogen and methyl) were devoid of significant activity, while 5-Bu derivatives exhibited prominent potency. In this study, on the other hand, both monoaryl- and bisarylpyrimidines were potent inhibitors of PGE2 production regardless the length of the C-5 substituent (hydrogen, Me, n-butyl). Moreover, the shorter the C-5 substituent the higher potency to inhibit PGE2 production was observed 2-Amino-4,6-diphenylpyrimidine was the best inhibitor of PGE2 production with IC50 = 3 nM and no cytotoxicity. The most potent inhibitors deserve further preclin. evaluation as potential anti-inflammatory agents.

The article 《Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production》 also mentions many details about this compound(7153-13-1)Recommanded Product: 7153-13-1, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17190-29-3, is researched, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NOJournal, Canadian Journal of Chemistry called Metal(II) Schiff base complexes as catalysts for the high-regioselective conversion of epoxides to β-hydroxy nitriles in glycol solvents, Author is Naeimi, Hossein; Moradian, Mohsen, the main research direction is regioselective preparation hydroxy nitrile; metal Schiff base catalyst ring opening epoxide potassium cyanide.Formula: C9H9NO.

A facile preparation of 3-hydroxy propanenitrile derivatives is described involving ring opening of epoxides with potassium cyanide in glycol solvents in the presence of Schiff base complexes as catalysts. This method occurs under neutral and mild conditions with high yields and high regioselectivity. Thus, several β-hydroxy nitriles, useful intermediates toward biol.-active mols., are easily obtained at room temperature

The article 《Metal(II) Schiff base complexes as catalysts for the high-regioselective conversion of epoxides to β-hydroxy nitriles in glycol solvents》 also mentions many details about this compound(17190-29-3)Formula: C9H9NO, you can pay attention to it, because details determine success or failure

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Synthetic Route of C9H9NO. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Biocatalytic Processes for the Synthesis of Chiral Alcohols. Author is Zheng, Gao-Wei; Ni, Yan; Xu, Jian-He.

A review. Recently, key advances in mol. biol. and protein engineering techniques have yielded more practical biocatalytic processes for the synthesis of chiral alcs. This chapter discusses these cases, which focusing on biocatalytic processes implemented on industrial scale or with a great industrial potential for the synthesis of chiral alcs. Apart from chem. approaches, various biocatalytic strategies have been developed, including the use of, for example, ketoreductases (KREDs), and lipases. Examples of enzymic processes for the production of chiral statin intermediates are discussed in the chapter, mainly focused on those with potential applicability or being applied on an industrial scale. It explores a few biocatalytic methods for the synthesis of optically pure Et 2-hydroxy-4-phenylbutyrate (HPBE), (S)-4-chloro-3-hydroxybutyrate ((S)-CHBE), 3-quinuclidinol, and 3-hydroxy-3-phenylpropanenitrile (HPPN). Optically pure halogen-substituted 1-henylethanols are an important class of chiral building blocks. Finally, the chapter describes some biocatalytic processes for the synthesis of optically active halogen-substituted 1-phenylethanols.

The article 《Biocatalytic Processes for the Synthesis of Chiral Alcohols》 also mentions many details about this compound(17190-29-3)Synthetic Route of C9H9NO, you can pay attention to it, because details determine success or failure

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Pyrazole – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Gostevskii, B. A.; Kruglaya, O. A.; Albanov, A. I.; Vyazankin, N. S. researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Name: 3-Hydroxy-3-phenylpropanenitrile.They published the article 《Reactions of cyanomethyltrimethylsilane with aldehydes. Synthesis of β-hydroxy carbonitriles》 about this compound( cas:17190-29-3 ) in Zhurnal Organicheskoi Khimii. Keywords: cyanomethyltrimethylsilane reaction aldehyde ketone; silane cyanomethyltrimethyl reaction aldehyde. We’ll tell you more about this compound (cas:17190-29-3).

RCHO (R = MeCH:CH, Ph, PhCH:CH) reacted with Me3SiCH2CN at 20° in the presence of KCN-18-crown-6 to give 69.5-73.2% Me3SiOCHRCH2CN, which were hydrolyzed to the corresponding HOCHRCH2CN. Analogous reaction with HCCCOPr yielded 33.1% HCCC(OSiMe3):CHEt.

The article 《Reactions of cyanomethyltrimethylsilane with aldehydes. Synthesis of β-hydroxy carbonitriles》 also mentions many details about this compound(17190-29-3)Name: 3-Hydroxy-3-phenylpropanenitrile, you can pay attention to it, because details determine success or failure

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Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of (1H-Imidazol-2-yl)methanamine dihydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about NMR Characterization of Hydrate and Aldehyde Forms of Imidazole-2-carboxaldehyde and Derivatives. Author is Lazaro Martinez, Juan Manuel; Romasanta, Pablo Nicolas; Chattah, Ana Karina; Buldain, Graciela Yolanda.

The existence and stability of the aldehyde-hydrate form of imidazole-2-carboxaldehyde (4) were studied using FTIR together with solution- and solid-state NMR experiments The results allowed us to conclude that the hydrate form was stable and precipitated at pH = 8.0 and that the aldehyde form was isolated at pH = 6.5 and 9.5. Moreover, the presence of the aldehyde-hydrate form was studied through NMR experiments in D2O at both alk. and acidic pH. In addition, the tautomeric forms of the 2-substituted imidazole compounds were also analyzed to investigate the influence of the hybridization on the carbon adjacent to the imidazole ring, by 13C NMR in DMSO-d6, acetone-d6, and CDCl3. The presence of the syn- and anti-isomers of oxime 8 obtained from 4 were characterized by solid-state NMR and variable-temperature NMR experiments in acetone-d6.

The article 《NMR Characterization of Hydrate and Aldehyde Forms of Imidazole-2-carboxaldehyde and Derivatives》 also mentions many details about this compound(22600-77-7)Application In Synthesis of (1H-Imidazol-2-yl)methanamine dihydrochloride, you can pay attention to it, because details determine success or failure

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Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics