Tag: M.W:200-300

Adding some certain compound to certain chemical reactions, such as: 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18048-64-1. 18048-64-1

A solution of 3′-amino-2′-hydroxy-1,1′-biphenyl-3-carboxylic acid hydrochloride salt (1.31 g 5.725 mmol) in methanol water, obtained as described in Example 4′, was cooled to 0-5 C and a solution of sodium nitrite (0,403 g, 5.840 mmol) in water (2 ml) was added over 15 minutes. The reaction was stirred at 0-10 C for one hour and then it was heated to 20 C. Triethylamine (about 2,5 ml) was added to bring the pH to 8-9 and 1-(3,4-dimethylphenyl)-3-methyl-1 H-pyrazol-5-ona (1.16 g, 5,725 mmol) was added in one portion. The mixture was stirred for 2 hours at 20 C maintaining the pH 8-9. Hydrochloric acid (4M, about 4 ml) was added to adjust the pH to 1.5-2.0. The precipitate was filtered, washed with water and dried at 40 C to yield 2.492 g (93%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one.

83-10-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 83-10-3 name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 4) N-(2-chloro-5-fluoro-4-hydroxyphenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide To a suspension of 4-amino-5-chloro-2-fluorophenol (0.97 g, 6 mmol) and 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (1.42 g, 6.12 mmol) in DMF (20 mL) was added EDCI (0.38 mg, 7.2 mmol) and HOAT (0.16 g, 1.2 mmol). The mixture was allowed to warm up to 80 C. and stirred for 24 hours. Then H2O (200 mL) and EtOAc (2 mL) was added. The resulted mixture was stirred at 0 C. for 2 hours, then filtered to give the title compound as a light brown solid (1.2 g, 53.2%). MS (ESI, pos. ion) m/z: 376.1 [M+H]+; 1H NMR (400 MHz, DMSO-d6): delta (ppm) 2.68 (s, 3H), 3.34 (s, 3H), 7.02-7.04 (d, J=8.8 Hz, 1H), 7.41-7.43 (m, 2H), 7.48-7.52 (m, 1H), 7.56-7.60 (m, 2H), 829-8.33 (d, J=13.8 Hz, 1H), 10.08 (s, 1H), 10.95 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, and friends who are interested can also refer to it.

10250-64-3, Adding a certain compound to certain chemical reactions, such as: 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10250-64-3.

A mixture of HATU (0.5593 g, 1.471 mmol), DIPEA (0.7066 ml, 4.045 mmol), N- (2-aminoethyl) -4-ethoxybenzamide hydrochloride (0.300 g, 1.226 iranol) and l-methyl-3-phenyl-lH-pyrazole-5- carboxylic acid (0.2479 g, 1.226 mmol) in THF (15 mL) was stirred at room temperature overnight. The mixture was quenched with water (150 ml) and the solid filtered, dried on high vacuum and purified on silica gel by eluting with 75% EtOAc/Hex. The pure material was recrystallized from EtOAc/hexanes to give N- (2- (4-ethoxybenzamido) ethyl) -1-methyl- 3-phenyl-lH-pyrazole-5-carboxamide (0.145 g, 30%) as a white solid: 1H NMR (400 MHz, DMSOd6) delta 1.33 (t, J = 7.0 Hz, 3H), 3.42 (br, 4H), 4.05-4.10 (m, 5H), 6.97 (d, J = 8.8 Hz, 2H), 7.23 (s, IH), 7.32 (t, J = 7.3 Hz, IH), 7.43