Li, Jun-Chi et al. published their research in Crystal Growth & Design in 2016 | CAS: 45887-08-9

3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Category: pyrazoles-derivatives

Ligand Coordination Site-Directed Assembly of Copper(I) Iodide Complexes of ((Pyridyl)-1-pyrazolyl)pyridine was written by Li, Jun-Chi;Li, Hong-Xi;Li, Hai-Yan;Gong, Wei-Jie;Lang, Jian-Ping. And the article was included in Crystal Growth & Design in 2016.Category: pyrazoles-derivatives This article mentions the following:

((Pyridinyl)-1H-pyrazolyl)pyridine (pypzpy) ligands in which the pyrazolyl ring at 1 and 3 positions is substituted by two 2-, 3-, or 4-pyridyl groups were prepared Reaction of CuI with 2-(1-(pyridin-2-yl)-1H-pyrazolyl)pyridine (2,2′-pypzpy) in MeCN at room temperature or solvothermal reaction of the same components at 120° afforded a binuclear complex [{(2,2′-pypzpy)Cu}(μ-I)]2 (1). Treatment of CuI with 3-(1-(pyridin-2-yl)-1H-pyrazolyl)pyridine (3,2′-pypzpy) at room temperature or at 120° produced 1-dimensional (1D) polymer [{Cu33-I)3}(μ-3,2′-pypzpy)]n (2) and one two-dimensional (2D) polymer [{Cu2(μ-I)(μ3-I)}2(3,2′-pypzpy)2]n (3), resp. Similar reactions of CuI with 4-(1-(pyridin-2-yl)-1H-pyrazolyl)pyridine (4,2′-pypzpy) at room temperature or at 150° yielded one 1-dimensional polymeric complex [{Cu(μ3-I)}2(4,2′-pypzpy)2{Cu(μ-I)}2]n (4). [{Cu33-I)3}(μ-2,3′-pypzpy)]n (5), [(CuI)(μ-2,3′-pypzpy)]2 (6), [(Cu2I2)(3,3′-pypzpy)] (7), [(CuI)(4,3′-pypzpy)] (8), [{Cu(μ3-I)}2(μ-2,4′-pypzpy)2{Cu(μ-I)}2]n (9), [(CuI)(3,4′-pypzpy)] (10), and [(CuI)(μ-4,4′-pypzpy)]n (11) could be isolated by solution reactions or solvothermal reactions of CuI with 2-, 3-, 4-(1-(pyridin-3-yl)-1H-pyrazolyl)pyridine (2,3′-, 3,3′-, 4,3′-pypzpy), or 2-, 3-, 4-(1-(pyridin-4-yl)-1H-pyrazolyl)pyridine (2,4′-, 3,4′-, 4,4′-pypzpy). Compounds 111 were characterized by IR, elemental anal., powder x-ray diffraction, and single-crystal X-ray crystallog. Complex 1 contains a normal [Cu(μ-I)]2 dimeric structure. 2 And 5 consist of a unique displaced staircase chain [Cu23-I)2]n. Complex 3 has a 2-dimensional network formed by linking chairlike [Cu2(μ-I)(μ3-I)]2 units with two pairs of 3,2′-pypzpy bridges. Complexes 4 and 9 have a rare 1-dimensional triple chain, in which one internal 1-dimensional ladder-like chain [Cu23-I)2]n is connected with two zigzag chains [Cu(μ-I)]n via 4,2′-pypzpy or 2,4′-pypzpy ligands. 6 Consists of two [CuI] units interconnected by two 2,3′-pypzpy ligands. Compound 11 contains a 1-dimensional chain assembled by monomeric [CuI] units and 4,4′-pypzpy ligands. The luminescent properties of 111 in solid state were also studied at room temperature These results offer an interesting insight into how the coordination sites of the pypzpy ligands exert great impact on their coordination modes, the coordination spheres of the Cu(I) centers, the formation of the [CunIn] motifs and the topol. structures of the final complexes. In the experiment, the researchers used many compounds, for example, 3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9Category: pyrazoles-derivatives).

3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Channabasaveshwar, V. et al. published their research in Indian Journal of Chemistry in 1994 | CAS: 934-48-5

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 934-48-5

Reactions of 4-(4-thiazolyl)sydnones in acid media: synthesis of 3-aryl-4-[2-(3,5-dimethyl/phenylpyrazol-1-yl)thiazol-4-yl]sydnones was written by Channabasaveshwar, V.;Yelamaggad, V.;Hiremath, Uma S.;Badami, Bharati V.. And the article was included in Indian Journal of Chemistry in 1994.Application of 934-48-5 This article mentions the following:

Acid stability of 4-(4-thiazolyl)sydnones was exploited in the preparation of the title compounds I (R = H, Cl, Me, MeO; R1 = Me, Ph) from 3-aryl-4-(2-hydrazino-4-thiazolyl)dydnones and 1,3-dicarbonyl compounds In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Application of 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zhang, Yingyu et al. published their research in Anhui Nongye Daxue Xuebao in 2014 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Formula: C5H9N3

Volatile components in mycelia and fruiting bodies of the artificial culture of Ophiocordyceps longissima was written by Zhang, Yingyu;Liu, Yang;Li, Yangmei;Zhang, Longwa;Li, Chunru. And the article was included in Anhui Nongye Daxue Xuebao in 2014.Formula: C5H9N3 This article mentions the following:

The volatile compounds were extracted from the mycelia and fruiting bodies of the artificial culture of Ophiocordyceps longissima using simultaneous distillation and extraction (SDE) method. Their volatile components were analyzed using gas chromatog.-mass spectrometry (GC-MS). The results showed that culture conditions had great influence on the content and number of volatile components; however, little impact on component classes was observed The main volatile substances in mycelia were ketones, alcs., alkenes, phenols and ethers, while alcs., aldehydes, and phenols are main volatile compounds in fruiting bodies. Twenty compounds were detected in the mycelia liquid in which the content of 1-octene-3-alc. (37.70%) was the highest. Six compounds were identified from the artificial culture of the fruiting bodies with the content of 1-octene-3-alc.(51.93%) and butylated hydroxytoluene (38.37%) being relatively high. The compounds of 1-octen-3-ol and butylated hydroxytoluene are two common constituents in both artificial cultures and their contents were accounted for 51.66% and 90.30% of the total volatile components in mycelia and fruiting body, resp. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Formula: C5H9N3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Formula: C5H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ali, Sh. Shaukat et al. published their research in Pakistan Journal of Scientific and Industrial Research in 1993 | CAS: 934-48-5

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: 934-48-5

Organic reactions in the aqueous medium. Part VI. Synthesis of substituted pyrazoles and pyrazolones was written by Ali, Sh. Shaukat;Ashraf, C. M.;Younas, M.;Ehsan, A.. And the article was included in Pakistan Journal of Scientific and Industrial Research in 1993.Recommanded Product: 934-48-5 This article mentions the following:

The reactions of semicarbazide hydrochloride and hydrazine monohydrate with Et acetoacetate, acetylacetone, benzoylacetone, and dibenzoylmethane leading to the formation of pyrazole and pyrazolone derivatives have been intensively studied in aqueous as well as in nonaqueous medium under various sets of conditions. This has resulted in the development of simple and convenient methods for the synthesis of pure Et acetoacetate semicarbazone, 3-methylpyrazol-5-one-1-carboxamide, 3-methylpyrazol-5-one, 3,5-dimethylpyrazole-1-carboxamide, 3,5-dimethylpyrazole, 3-phenyl-5-methylpyrazole-1-carboxamide, 3-phenyl-5-methylpyrazole, and 3,5-diphenylpyrazole. It has been suggested that the reaction of semicarbazide hydrochloride with β-diketo compounds proceeds through four stages. A reaction scheme has been proposed to explain the formation of different products. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Recommanded Product: 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Johannes, Jeffrey W. et al. published their research in ACS Medicinal Chemistry Letters in 2015 | CAS: 18213-75-7

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Product Details of 18213-75-7

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology was written by Johannes, Jeffrey W.;Almeida, Lynsie;Barlaam, Bernard;Boriack-Sjodin, P. Ann;Casella, Robert;Croft, Rosemary A.;Dishington, Allan P.;Gingipalli, Lakshmaiah;Gu, Chungang;Hawkins, Janet L.;Holmes, Jane L.;Howard, Tina;Huang, Jian;Ioannidis, Stephanos;Kazmirski, Steven;Lamb, Michelle L.;McGuire, Thomas M.;Moore, Jane E.;Ogg, Derek;Patel, Anil;Pike, Kurt G.;Pontz, Timothy;Robb, Graeme R.;Su, Nancy;Wang, Haiyun;Wu, Xiaoyun;Zhang, Hai-Jun;Zhang, Yue;Zheng, Xiaolan;Wang, Tao. And the article was included in ACS Medicinal Chemistry Letters in 2015.Product Details of 18213-75-7 This article mentions the following:

The canonical Wnt pathway plays an important role in embryonic development, adult tissue homeostasis, and cancer. Germline mutations of several Wnt pathway components, such as Axin, APC, and ss-catenin, can lead to oncogenesis. Inhibition of the poly(ADP-ribose) polymerase (PARP) catalytic domain of the tankyrases (TNKS1 and TNKS2) is known to inhibit the Wnt pathway via increased stabilization of Axin. In order to explore the consequences of tankyrase and Wnt pathway inhibition in preclin. models of cancer and its impact on normal tissue, the authors sought a small mol. inhibitor of TNKS1/2 with suitable physicochem. properties and pharmacokinetics for hypothesis testing in vivo. Starting from a 2-Ph quinazolinone hit I, the authors discovered the pyrrolopyrimidinone compound II (AZ6102), which is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows 5 nM Wnt pathway inhibition in DLD-1 cells. Moreover, compound II can be formulated well in a clin. relevant i.v. solution at 20 mg/mL, has demonstrated good pharmacokinetics in preclin. species, and shows low Caco2 efflux to avoid possible tumor resistance mechanisms. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7Product Details of 18213-75-7).

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Product Details of 18213-75-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Siebeneicher, Holger et al. published their research in ChemMedChem in 2016 | CAS: 5334-39-4

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.SDS of cas: 5334-39-4

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876 was written by Siebeneicher, Holger;Cleve, Arwed;Rehwinkel, Hartmut;Neuhaus, Roland;Heisler, Iring;Mueller, Thomas;Bauser, Marcus;Buchmann, Bernd. And the article was included in ChemMedChem in 2016.SDS of cas: 5334-39-4 This article mentions the following:

Despite the long-known fact that the facilitative glucose transporter GLUT1 is one of the key players safeguarding the increase in glucose consumption of many tumor entities even under conditions of normal oxygen supply (known as the Warburg effect), only few endeavors have been undertaken to find a GLUT1-selective small-mol. inhibitor. Because other transporters of the GLUT1 family are involved in crucial processes, these transporters should not be addressed by such an inhibitor. A high-throughput screen against a library of ∼3 million compounds was performed to find a small mol. with this challenging potency and selectivity profile. The N-(1H-pyrazol-4-yl)quinoline-4-carboxamides were identified as an excellent starting point for further compound optimization. After extensive structure-activity relationship explorations, single-digit nanomolar inhibitors with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4 were obtained. The most promising compound, BAY-876 [N4-[1-(4-cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide], showed good metabolic stability in vitro and high oral bioavailability in vivo. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4SDS of cas: 5334-39-4).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.SDS of cas: 5334-39-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Bharate, Sandip B. et al. published their research in Bioorganic & Medicinal Chemistry in 2008 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Product Details of 3528-58-3

Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-α and IL-6 inhibitors was written by Bharate, Sandip B.;Mahajan, Tushar R.;Gole, Yogesh R.;Nambiar, Mahesh;Matan, T. T.;Kulkarni-Almeida, Asha;Balachandran, Sarala;Junjappa, H.;Balakrishnan, Arun;Vishwakarma, Ram A.. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Product Details of 3528-58-3 This article mentions the following:

In the present article, we have synthesized three different series of pyrazolo[3,4-b]pyridines and their structural analogs using novel synthetic strategy involving one-pot condensation of 5,6-dihydro-4H-pyran-3-carbaldehyde/2-formyl-3,4,6-tri-O-methyl–glucal/chromone-3-carbaldehyde with heteroaromatic amines. All synthesized compounds were evaluated for their anti-inflammatory activity against TNF-α and IL-6. Out of 28 compounds screened, 40, 51, 52 and 56 (I) exhibited promising activity against IL-6 with 60-65% inhibition at 10 μM concentration Amongst these, 51, 52 and 56 showed potent IL-6 inhibitory activity with IC50‘s of 0.2, 0.3 and 0.16 μM, resp. Compound 56 was not cytotoxic in CCK-8 cells up to the concentration of >100 μM. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Product Details of 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Product Details of 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Waring, Michael J. et al. published their research in MedChemComm in 2012 | CAS: 55361-49-4

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Safety of 1-Ethyl-1H-pyrazol-3-amine

Property based optimisation of glucokinase activators – discovery of the phase IIb clinical candidate AZD1656 was written by Waring, Michael J.;Clarke, David S.;Fenwick, Mark D.;Godfrey, Linda;Groombridge, Sam D.;Johnstone, Craig;McKerrecher, Darren;Pike, Kurt G.;Rayner, John W.;Robb, Graeme R.;Wilson, Ingrid. And the article was included in MedChemComm in 2012.Safety of 1-Ethyl-1H-pyrazol-3-amine This article mentions the following:

Glucokinase plays a central role in glucose homeostasis and small mol. activators of the glucokinase enzyme have been the subject of significant pharmaceutical research in the quest for agents capable of delivering improved glycemic control. Here we describe our medicinal chem. campaign to improve on our previously described development candidate in this area, AZD1092, focussed on removal of Ames liability and improved permeability characteristics. This work culminated in the superior compound AZD1656 which has progressed to phase 2 clin. trials. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Safety of 1-Ethyl-1H-pyrazol-3-amine).

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Safety of 1-Ethyl-1H-pyrazol-3-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zhang, Lei et al. published their research in Journal of Medicinal Chemistry in 2014 | CAS: 63725-52-0

6-Chloro-1-methylpyrazolo[5,4-b]pyridine (cas: 63725-52-0) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Electric Literature of C7H6ClN3

Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]-pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator was written by Zhang, Lei;Balan, Gayatri;Barreiro, Gabriela;Boscoe, Brian P.;Chenard, Lois K.;Cianfrogna, Julie;Claffey, Michelle M.;Chen, Laigao;Coffman, Karen J.;Drozda, Susan E.;Dunetz, Joshua R.;Fonseca, Kari R.;Galatsis, Paul;Grimwood, Sarah;Lazzaro, John T.;Mancuso, Jessica Y.;Miller, Emily L.;Reese, Matthew R.;Rogers, Bruce N.;Sakurada, Isao;Skaddan, Marc;Smith, Deborah L.;Stepan, Antonia F.;Trapa, Patrick;Tuttle, Jamison B.;Verhoest, Patrick R.;Walker, Daniel P.;Wright, Ann S.;Zaleska, Margaret M.;Zasadny, Kenneth;Shaffer, Christopher L.. And the article was included in Journal of Medicinal Chemistry in 2014.Electric Literature of C7H6ClN3 This article mentions the following:

A novel series of pyrazolopyrazines is herein disclosed as mGluR5 neg. allosteric modulators (NAMs). Starting from a high-throughput screen (HTS) hit (1), a systematic structure-activity relationship (SAR) study was conducted with a specific focus on balancing pharmacol. potency with physicochem. and pharmacokinetic (PK) properties. This effort led to the discovery of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]-pyrazine (PF470, 14) as a highly potent, selective, and orally bioavailable mGluR5 NAM. Compound 14 demonstrated robust efficacy in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-rendered Parkinsonian nonhuman primate model of l-DOPA-induced dyskinesia (PD-LID). However, the progression of 14 to the clinic was terminated because of a potentially mechanism-mediated finding consistent with a delayed-type immune-mediated type IV hypersensitivity in a 90-day NHP regulatory toxicol. study. In the experiment, the researchers used many compounds, for example, 6-Chloro-1-methylpyrazolo[5,4-b]pyridine (cas: 63725-52-0Electric Literature of C7H6ClN3).

6-Chloro-1-methylpyrazolo[5,4-b]pyridine (cas: 63725-52-0) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Electric Literature of C7H6ClN3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reddy, P. S. N. et al. published their research in Heterocyclic Communications in 2003 | CAS: 14678-93-4

5-Amino-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid (cas: 14678-93-4) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.SDS of cas: 14678-93-4

Synthesis of pyrazolo[3′,4′:4,5]pyrimido [2,3-c][1,4] benzoxazines. A new heterocyclic ring system was written by Reddy, P. S. N.;Reddy, Pragati;Reddy, G. Jagath;Rao, K. Srinivasa. And the article was included in Heterocyclic Communications in 2003.SDS of cas: 14678-93-4 This article mentions the following:

A series of 4-oxo-pyrazolo[3′,4′:4,5]pyrimido[2,3-c][1,4] benzoxazines I (R1 = H, Cl, F, Me, COMe; R2 = H, Cl, Me; R3 = H, Me) were prepared by cyclocondensation of 1,4-benzoxazinones with 5-aminopyrazole-4-carboxylic acids in a single step. In the experiment, the researchers used many compounds, for example, 5-Amino-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid (cas: 14678-93-4SDS of cas: 14678-93-4).

5-Amino-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid (cas: 14678-93-4) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.SDS of cas: 14678-93-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics