pyrazoles-derivatives

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14521-80-3, name is 3-Bromo-1H-pyrazole, A new synthetic method of this compound is introduced below., 14521-80-3

Step C: Preparation of2-(3-Bromo-1 H-pyrazol- 1 -yl)-3-chloropyridineTo a mixture of 2,3-dichloropyridine (27.4 g, 185 mmol) and 3-bromopyrazole (i.e. the product of Step B) (25.4 g, 176 mmol) in dry N,N-dimethylformamide (88 mE) was added potassium carbonate (48.6 g, 352 mmol), and the reaction mixture was heated to 125 C. for 18 hours. The reaction mixture was cooled to room temperature and poured into ice water (800 mE). A precipitate formed. The precipitated solids were stirred for 1.5 hrs, filtered and washed with water(2×100 mE). The solid filter cake was taken up in methylene chloride and washed sequentially with water, iN hydrochlonc acid, saturated aqueous sodium bicarbonate solution, and brine. The organic extracts were then dried over magnesium sulfate and concentrated to afford 39.9 g of a pink solid. Thecrude solid was suspended in hexane and stirred vigorously for 1 hr. The solids were filtered, washed with hexane and dried to afford the title product as an off-white powder (30.4 g) determined to be >94% pure by NMR. This material was used without thrther purification in Step D.?H NMR (CDC13) oe 6.52 (s, 1H), 7.30 (dd, 1H), 7.92 (d, 1H), 8.05 (s, 1H), 8.43 (d, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding some certain compound to certain chemical reactions, such as: 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5932-27-4. 5932-27-4

Example 15, Step B[00153] To a solution of compound 15b (38.5 g, 275 mmol) in CH3CN (700 mL) was added iodine (69.8 g, 275 mmol) followed by eerie ammonium nitrate (150.7 g, 275 mmol). The reaction mixture was then stirred for 12 hours at r.t. Additional iodine (17.4 g) was added and stirring continued for 8 h, following which a cold solution of 5percent NaHSOawas added to the reaction mixture. The white precipitate was filtered through a celite pad and washed with water and EtOAc. The filtrate layers were separated, the aqueous phase extracted with EtOAc and the organic phases were washed with water, dried over MgS04, filtered and solvent evaporated in vacuo to afford compound 15c (38 g, 52percent) as a slightly yellow solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Ethyl 1H-pyrazole-3-carboxylate.

The chemical industry reduces the impact on the environment during synthesis 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, I believe this compound will play a more active role in future production and life. 39806-90-1

Part B:; The compound 52 (33 mg, 0.08 mmol), 3-iodo-1-methylpyrazole (21 mg, 0.1 mmol), K2CO3 (27 mg, 0.2 mmol), CuI (2 mg, 0.01 mmol) and trans-N, N’-bismethyl-i ,2-cyclohexane diamine (4 muL) were mixed in toluene (3 mL) under Argon. The mixture was sealed under Argon and heated up to 1000C and stirred overnight. After cooling to room temperature, the reaction was worked up and the crude was purified by Prep-LC gave the product 53 (29 mg). HPLC-MS tR = 1.88 min (UV254 nm); mass calculated for formula C25H3IN7O2S 493.2, observed LCMS m/z 494.2 (M+H).

The chemical industry reduces the impact on the environment during synthesis 39806-90-1. I believe this compound will play a more active role in future production and life.

4522-35-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4522-35-4, name is 3-Iodo-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of 3-iodo-1H-pyrazole (1 g, 5.16 mmol) and p-TsOH (88 mg, 0.52 mmol) in DCM (15 mL) was added DHP (0.56 mL, 6.19 mmol) and stirred atr.t. for2 hr. The reaction mixture was washed with satd. NaHCO3 and brine, dried over anhy. Na2SO4 and concentrated. The residue was purified by flash chromatography (silica gel, 0 -. 10% EtOAcin PE) to give 3-iodo-1-(oxan-2-yl)-1H-pyrazole (1.4 g). LC-MS (m/z 279 (M¡ÂH).

The synthetic route of 3-Iodo-1H-pyrazole has been constantly updated, and we look forward to future research findings.

330792-70-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

[0319] A mixture of (E)-2-( 4-( dimethylamino )-2-oxobut-3-enyl)isoindoline-1 ,3-dione ( 600 mg,2.33 mmol) and 5-amino-3-(4-phenoxy phenyl)-IH-pyrazole-4-carbonitrile (642 mg, 2.33mmol) in 20 mL of HOAc was stirred and heated to 120 ¡ãC for 15 hr. The mixture wasconcentrated and suspended in 30 mL of solvent (PE/EA = 411). The mixture was filtered andthe solid was purified by pre-TLC (DCM/EA = 5011) to give 430 mg (40percent) of 7-((1,3-dioxoisoindolin-2-yl )methyl)-2-( 4-phenoxyphenyl )pyrazolo [ 1 ,5-a ]pyrimidine-3-carbonitrile as a solid. 1H NMR (400 MHz, DMSO-d6) 8 8.74 (d, J = 4.4 Hz, IH), 8.05 (d, J = 8.8 Hz, 2H),7.96-7.90 (m, IH), 7.88-7.85 (m, 2H), 7.50 (d, J = 4.4 Hz, IH), 7.46-7.37 (m, 2H), 7.21-7.09 (m,5H), 5.32 (s, 2H). MS (ESI) m/e [M+It 472.1.

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Adding some certain compound to certain chemical reactions, such as: 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39806-90-1. 39806-90-1

To a solution of intermediate 35.8 (30 mg, 0.097 mmol) in anhydrous l,4-Dioxane (3 mL) was added 4-iodo-l-methyl-lH-pyrazole (40.3 mg, 0.194 mmol), K3PO4 (61.7 mg, 0.291 mmol), (trans)-N, N2-dimethylcy cl ohexane-l, 2-diamine (10 mg, 0.070 mmol) and Cul (5 mg, 0.026 mmol), and the resulting mixture was stirred at 90C under N2 protection for 16 hours. Afterward, the reaction was filtered and concentrated. The crude residue was purified by pre-HPLC (TFA) to give example 35.9, 5-chloro-4-fluoro-l-(l-methyl-lH-pyrazol-4-yl)-6-(l-(oxetan-3-yl)piperidin- 4-yl)-lH-indazole, TFA salt. MS (ESI) m/z calc?d for C19H22CIFN5O [M+H]+ 390, found 390. NMR (500 MHz, CDCI3): d 8.17 (s, 1H), 8.03 (s, 1H), 7.86 (s, 1H), 7.40 (s, 1H), 5.13 (t, .7=7.17 Hz, 2H), 4.81 (m, 2H), 4.18 (m, 1H), 4.03 (s, 3H), 3.59 (m, 2H), 3.43 (m, 1H), 2.78 (m, 2H), 2.46- 2.54 (m, 2H), 2.13 (m, 2H). LRRK2 ICso 6.9 nM.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-Iodo-1-methyl-1H-pyrazole.

A common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 402-61-9.

[(VIVO)(C5H5N2O2)2H2O]2H2O (2) VO(acac)2 (0.0265 g,0.1 mmol) and 5-pyrazol-1H-pyrazol-3-carboxylic acid (0.025 g,0.2 mmol) were mixed and stirred for 3 h in a solution of 95%methanol (8 mL) at room temperature. After two days, purplecrystals of complex were obtained. Yield (based on V): 0.036 g,48.78%. Anal. Calc. For C10H16N4O8V: C, 32.35; H, 4.3; N, 15.09.Found: C, 32.35; H, 4.28; N, 15.05.

The synthetic route of 5-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

5334-43-0, These common heterocyclic compound, 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Equimolar portionsof the intermediate compounds 1 (1 mmol) and the intermediatecompounds 3 (1 mmol) were dissolved in approximately 8 mL ofethanol. The reaction solution was allowed to stir at 80 8C for 2 huntil the reaction was complete. The reaction was monitored byTLC. Mostly, a precipitate formed and was then collected by suctionfiltration.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5334-43-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112758-40-4, name is 3-Methyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., 112758-40-4

3. 3-Methyl-1-(3-(tetrahydrofuran-2-yl)pyridin-2-yl)-1H-pyrazole-4-carbaldehyde; To a screw-cap test tube containing 2-fluoro-3-(tetrahydrofuran-2-yl)pyridine (148 mg, 0.88 mmol) in dimethylformamide (2.2 mL) are added 3-methyl-1H-pyrazole-4-carbaldehyde (81 mg, 0.74 mmol) and potassium carbonate (152 mg, 1.1 mmol). The reaction tube is quickly sealed (caution: build-up of pressure possible; use a safety shield) and stirred in a preheated oil bath at 110 C. for 18 h with the aid of a magnetic stirrer. The mixture is diluted with water and extracted with ethyl acetate. The organic layer is separated, dried over magnesium sulfate, filtered and the solvent evaporated in vacuo. The resulting residue is purified by silica gel using normal phase Isco chromatography eluting with hexane: acetone (gradient from 5 to 20% in acetone) to give 116 mg of the title compound. MS (m/z): 258 (M+1).

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., 35344-95-7

(E)-methyl 3-(l -methyl- lH-pyrazol-4-yl)acrylateCs2C03 (1.304g, 4 mmol) was added to a solution of lH-pyrazole-4-carbaldehyde (0.192 g, 2 mmol) in dioxane (8 mL) at room temperature. Trimethylphosphonoacetate (0.364g, 0.40 mmol) was added to this suspension, followed by DMSO (2 mL). The reaction mixture was heated to 100¡ãC overnight. It was then diluted with EtOAc (40 mL), and washed with water (40 mL) and brine (20 mL). The organic layer was concentrated under vacuum. The crude was purified by silica gel column chromatography using a 0-100percent gradient of EtOAc in hexanes to provide (E)-methyl 3 -(1 -methyl- lH-pyrazol-4- yl)acrylate (0.278 g). ES+ (M+H)+ 167

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.