pyrazoles-derivatives

A common compound: 5744-56-9, name is 1,3-Dimethyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 5744-56-9

Scheme I 1,3-Dimethyl-4-nitro-pyrazole-5-carboxylic acid One-hundred twelve g concentrated sulfuric acid is added to 42 ml 90% nitric acid at 70-80 C., 39 g of 1,3-dimethylpyrazole-5-carboxylic acid is added in portions over one hour such that the temperature does not go over 90 C. After 2.5 hours the reaction mixture is cooled and poured over ice. The resulting percipitate was filtered, dried, and recrystallized in ethanol, mp 141-142 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5744-56-9, other downstream synthetic routes, hurry up and to see.

26621-44-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26621-44-3, name is 3-Nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

MC-163-1 (2 g, 17.68 mmol, 1.0 eq), p-toluenesulfonic acid (336 mg, 1.668 mmol, 0.1 eq) was dissolved in 40 mL of tetrahydrofuran.Then DHP (1.6 g, 19.448 mmol, 1.1 eq) was added. The reaction was carried out at room temperature for 16 hours.The reaction solution was added with water 25 mL, and ethyl acetate 35 mL was extracted three times.The organic phase was washed with saturated brine and dried over anhydrous sodiumPurified by column (petroleum ether: ethyl acetate 20:1 to 5:1)Get oil MC-158-1(3.5g, 99%).

The synthetic route of 3-Nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.

2075-46-9, These common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Dimethyl sulphate (3.33g, 26.4mmol) was slowly added to a stirred solution of 2b (1.Og, 8.85mmol) in IN NaOH (1OmL) that had been warmed to 3O0C. After being stirred at r.t. for 3.5h, the reaction mixture was extracted with ethyl acetate (10mLx4), combined the organic phase, washed with brine (2OmL), dried over MgSO4, filtered and concentrated. The residue was triturated with petrol and filtered to give 3a (0.98g, 87%) as a white solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2075-46-9.

1453-58-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The N-nucleophile (1.47 mmol), CuI (Sigma-Aldrich, 99.999percent purity, 0.147 mmol), MnF2 (Sigma-Aldrich, 98percent purity, 0.441 mmol), KOH (2.94 mmol), the aryl halide (2.21 mmol), trans-1,2-diaminocyclohexane (0.294 mmol) and water (0.75 mL) were added to a reaction vial and a screw cap was fitted to it. The reaction mixture was stirred under air in a closed system at 60C for 24 h. After cooling to room temperature, the mixture was diluted with dichloromethane and filtered through a pad of Celite. The combined organic extracts were dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica-gel column chromatography to afford the N-arylated product. The identity and purity of known products was confirmed by 1H and 13C NMR spectroscopic analysis.

The synthetic route of 1453-58-3 has been constantly updated, and we look forward to future research findings.

39806-90-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To 4-iodo-1-methyl-1 H-pyrazole (1.0346 g, 4.97 mmol) in THF (20 ml) was added CuI (0.36g, 1.89 mmol), and PdCI2(PPh3J2. The reaction flask was purged with N2 and NEt3 (10.4 ml_, 75 mmol) and ethynyl-trimethyl-silane (5.27 ml, 37 mmol) was added. The reaction mixture was heated at 80 0C overnight for 21 hours. After cooling to room temperature, the reaction was diluted with EtOAc and filtered. The filtrate was washed successively with 1 M HCI, 1 M NaOH and H2O. The organic phase was dried over MgSO4, filtered and concentrated in vacuo. The crude product was purified by column chromatography (20:8 v/v petroleum ether : EtOAc to give the product as a brown oil (676 mg).

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, A new synthetic method of this compound is introduced below., 120068-79-3

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

5932-27-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

R – (+) – propylene oxide (3.65 g) and After 4-amino-benzotrifluoride ethanol solution of chloride (7.78 mL) (10 mL) was stirred for 4 hours at room temperature, lithium bromide (1.64 g), R – (+) – was stirred 9 days at room temperature was added propylene oxide (1.66 g). The reaction mixture was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (n- hexane / ethyl acetate) to give the title compound (10.5 g).

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330792-70-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 330792-70-6 name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a dry 10 L three-necked flask was added Compound 1a (600 g, 2.17 mol)Compound 2a (815 g, 2.39 mol),Powdered cesium carbonate (1417 g, 4.35 mol) and N, N-methylformamide (DMF, 6 L) were added,Mechanical stirring, heating the internal temperature rose to 80 (about 1.5 hours)After 2 hours to send HPLC monitoring reaction, the reaction is complete, stop heating, cooled to room temperature,Then add 10L ethyl acetate and 15L water, stirred for 30 minutes (speed 200), allowed to stand,Liquid separation, the water phase to discard, the organic phase with 1kg anhydrous sodium sulfate and stir, filtered,The filtrate was concentrated dark reddish brown oil, the crude product was recrystallized twice with dioxane,Obtained pale yellow powdery solid 450g, yield 46.4percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, and friends who are interested can also refer to it.

A common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5334-40-7.

Preparation of 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester 4-Nitro-1H-pyrazole-3-carboxylic acid (1.00 kg, 6.37 mol, 1.0 wt) and methanol (8.00 L, 8.0 vol) were charged to a flange flask equipped with a mechanical stirrer, condenser and thermometer. The suspension was cooled to 0 to 5 C. under nitrogen and thionyl chloride (0.52 L, 7.12 mol, 0.52 vol) was added at this temperature. The mixture was warmed to 15 to 25 C. over 16 to 24 hours. Reaction completion was determined by 1H NMR analysis (d6-DMSO). The mixture was concentrated under vacuum at 35 to 45 C. Toluene (2.00 L, 2.0 vol) was charged to the residue and removed under vacuum at 35 to 45 C. The azeotrope was repeated twice using toluene (2.00 L, 2.0 vol) to give 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester (1.071 Kg, 98.3%) as an off white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitro-1H-pyrazole-3-carboxylic acid, its application will become more common.

A common compound: 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 18048-64-1

4- (7-amino-6-hydroxy-2,3-dihydro-1H – inden-5-yl) benzoic acid hydrobromide(0.5g, 1.43mmol) was dissolved in 15ml of concentrated hydrochloric acid, cooled to 0 , theretowas slowly added dropwise of NaNO2(0.11 g of, 1.51 mmol) aqueous solution (10ml), the reaction incubated0.5h, TLC detection starting material the reaction was complete.Thereto was added 1- (3,4-dimethylphenyl) -3-methyl-1H – pyrazol-5 (4 hydrogen) -one (0.29g, 1.43mmol), the reaction 15min,controlling the reaction temperature is 0 deg.] C, with saturated sodium bicarbonate to adjust the pH value of about 9, was added 10mlof absolute ethanol, naturally to room temperature after the reaction was continued for 24h, TLC detection starting material the reaction was complete,filtered and the resulting cake was washed with 40ml of hydrochloric acid solution (concentration of 2mol / L) washed several times with methanolpulping, beating dichloromethane, filtration give (Z) -4- (7- (2- (1- (3,4-dimethylphenyl) -3-methyl-5-oxo substituting 1,5-dihydro – pyrazol-4-ylidene) hydrazino-yl) -6-hydroxy-2,3-dihydro -1H-indan-5-yl) benzoic acid (0.33mg, yield 44 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 18048-64-1, other downstream synthetic routes, hurry up and to see.