pyrazoles-derivatives

Design, synthesis and herbicidal activities of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives as potential pigment biosynthesis inhibitors was written by Ma, Hong-Ju;Zhang, Jian-Hua;Xia, Xiang-Dong;Xu, Meng-Han;Ning, Jun;Li, Jian-Hong. And the article was included in Pest Management Science in 2014.COA of Formula: C4H5N3O2 This article mentions the following:

BACKGROUND With the objective of finding novel valuable herbicidal candidates, a series of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives were synthesized and their herbicide activities were evaluated in vivo. RESULTS The results showed that many target compounds expressed bleaching activities. Among these, compound 5 h showed the best bleaching activity to gramineous weeds, being able to produce the highest inhibition of chlorophyll level in seedlings of Pennisetum alopecuroides L. (IC₅₀ = 3.48 mg L-1). Moreover, compound 5 h expressed good selective toxicity between gramineous P. alopecuroides L. and broadleaf plant Brassica campestris L. CONCLUSIONS The present work demonstrates that pyrimidine derivatives containing pyrazole can be used as potential lead compounds for developing novel pigment biosynthesis inhibitors. 婕?2013 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4COA of Formula: C4H5N3O2).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 鎺矯).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.COA of Formula: C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Dipole moment and tautomeric form of 3(5)-nitropyrazole in dioxane solution was written by Aksamentova, T. N.;Krivoruchka, I. G.;Elokhina, V. N.;Vokin, A. I.;Lopyrev, V. A.;Turchaninov, V. K.. And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 1999.Formula: C4H5N3O2 This article mentions the following:

The dipole moments of 3(5)-nitropyrazole, its Me-substituted derivatives, and H-complexes with dioxane were measured exptl. and estimated by ab initio calculations (6-31G^* basis set). Comparison of the exptl. and calculated dipole moments suggests a shift of the tautomeric equilibrium toward the 3-nitro isomer. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Formula: C4H5N3O2).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Formula: C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of 1H-pyrazolo[3,4-b]pyridines was written by Haeufel, Jochen;Breitmaier, Eberhard. And the article was included in Angewandte Chemie in 1973.Recommanded Product: 3528-58-3 This article mentions the following:

The pyrazolopyridines [I; R = Me, Pr, Bu; R1 = H; or RR1 = (CH2)n, n = 4,5,6, or 10; R2 = Me, Et, Ph; R3 = H, Me] were prepared in 51-87% yield by reaction of the pyrazoles II with R1COCR:CHR4 (R4 = OH, alkoxy, NH2) in HOAc and subsequent precipitation with H2O, or addition of NaOH and extraction with Et2O, or distillation of HOAc. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Recommanded Product: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and biological activities of 3-substituted-6- pyrazolyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles was written by An, Yue;Yao, Mingxing;Zhou, Xiaoxia;Liu, Mingyang. And the article was included in Yingyong Huaxue in 2014.Synthetic Route of C11H10N2O2 This article mentions the following:

The three kinds of 1-methyl-5-substituted-pyrazole-3-carboxylic acid were obtained by 5-substituted-1H-pyrazole-3-Et formate based on methylation and hydrolysis of the ester. Then the six kinds of 3-substituted-4-amino-5-mercapto-1,2,4-triazole were obtained using the substituted carboxylic acid by a series of reaction. Finally, eighteen novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles compounds were synthesized by phosphorus chloride treatment of the above two obtained intermediate. The structures of all new compounds were characterized by IR, ¹H NMR, ¹³C NMR and elemental analyses. The preliminary test shows that all the compounds display plant growth regulator activity and antibacterial activity. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8Synthetic Route of C11H10N2O2).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 鎺矯).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Synthetic Route of C11H10N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electronic effects in the catalytic hydrosilylation with in-situ generated iron(II)-catalysts was written by Muller, Keven;Schubert, Anett;Jozak, Thomas;Ahrens-Botzong, Annegret;Schuenemann, Volker;Thiel, Werner R.. And the article was included in ChemCatChem in 2011.Electric Literature of C9H9N3 This article mentions the following:

In combination with different aromatic N,N-donors, iron acetate and octanoate are suitable catalyst precursors for the hydrosilylation of carbonyl compounds Iron octanoate can be used to perform this catalytic transformation in cheap and non-toxic petrol ether or heptane as the solvent and with versatile polymethylhydrosiloxane (PMHS) as the silane source. Investigation of the performed catalyst (iron octanoate + N,N-ligand + PMHS) by using Moessbauer spectroscopy suggests that the active species is a high-spin iron(II) system. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Electric Literature of C9H9N3).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Electric Literature of C9H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Transition metal azolates from metallocenes. Part 3: polymeric manganese(II) and nickel(II) pyrazolates; synthesis, characterization, and magnetochemistry was written by Storr, Alan;Summers, David A.;Thompson, Robert C.. And the article was included in Canadian Journal of Chemistry in 1998.Recommanded Product: 15953-73-8 This article mentions the following:

Direct reactions of nickelocene and manganocene with molten pyrazoles in an inert atm. or under vacuum gave the following metal pyrazolate compounds: [Ni(4-Xpz)₂]_x (X = H, Cl and pz = pyrazolate); [M(4-Xdmpz)₂]_x (X = Cl, Br and pzH = pyrazole). On the bases of indirect evidence all compounds are considered to have extended chain structures with metal ions linked in chains by double bridging pyrazolates. The two [Ni(4-Xpz)₂]_x compounds are diamagnetic compounds while all others are paramagnetic and reveal antiferromagnetic coupling between neighboring metal ions. Analyses of the magnetic data (Hamiltonian H = -2J 鍗?S_i-S_j) yields values of the exchange coupling compounds and -0.41 cm^-1 for the [Mn(4-Xpz)₂(4-XpzH)]_x compounds In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Recommanded Product: 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Nitro azines. 20. Simple syntheses of pyrazolo-condensed nitropyridines from aliphatic nitro synthons and aminopyrazoles was written by Rusinov, V. L.;Petrova, A. Yu.;Chupakhin, O. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1992.Recommanded Product: 55361-49-4 This article mentions the following:

Treating aminopyrazoles I (R, R¹ = H, Me, Ph) with the Na salt of O₂NCH(CHO)₂ in water gave 65-75% pyrazolopyridines II (R = H, R¹ = Ph, Me, H; R = Me, R¹ = Me, H; R = Ph, R¹ = H); and in AcOH 70-90% II (R = H, Me, Ph, R¹ = Ph; R = H, Me, R¹ = Me) were obtained. Addnl. obtained were pyrazolopyridines III (R = H, Me, R¹ = Ph). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Recommanded Product: 55361-49-4).

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 鎺矯).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 55361-49-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Thiophene isosteres: synthesis and pharmacological study of 3-(azol-1-yl)thienoisothiazole 1,1-dioxides was written by Vega, Salvador;Madronero, Ramon;Diaz, J. Antonio;Junquera, Francisco;Alonso, Javier;Darias, Victoriano;Bravo, Luis;Abdalah, Suzanne. And the article was included in European Journal of Medicinal Chemistry in 1988.Product Details of 15953-73-8 This article mentions the following:

Three series of new 3-(azol-1-yl)thienoisothiazole 1,1-dioxides, e.g., I (X = S, X¹ = CH; X = CH, CPh, X¹ = S: R, R¹, R² = H, Cl, Me) were synthesized and tested for antiinflammatory, analgesic and antipyretic activity as well as for acute toxicity. Acetylsalicylic acid was used as the reference standard In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Product Details of 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Molecular-orbital and structural descriptors in theoretical investigation of electroreduction of nitrodiazoles was written by Kolaric, Branko;Juranic, Ivan;Dumanovic, Dragica. And the article was included in Journal of the Serbian Chemical Society in 2005.Computed Properties of C4H5N3O2 This article mentions the following:

It is shown how a simple theor. approach can be used for the investigation of electro-organic reactions. Mononitroimidazoles and mononitropyrazoles were studied by the semiempirical MNDO-PM3 MO method. The electrochem. reduction potentials of diazoles have been correlated with the energy of the LUMO. It was found that an admirable correlation could be obtained by the introduction of simple structural descriptors as a correction to the energy of the LUMO. The interaction of a mol. with its surrounding depends on electrostatic potential and on steric hindrance. Most of these steric effects are taken into account using two parameters having a very limited set of integer values. The first (灏? is the position of a ring substituent regarding ring nitrogens, which accounts for the different orientations of dipole moments and for the different shape of the electrostatic potential. The second (structural) parameter (锜? is the type of the ring, which accounts mostly for different modes of electrode approach, and for different charge polarization patterns in two diazole rings. The extended correlation with E_LUMO, 灏?and 锜? is very good, having a regression coefficient r = 0.991. The intrinsic importance of 灏?and 锜?is exemplified by their high statistical weight In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Computed Properties of C4H5N3O2).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Computed Properties of C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development was written by Blake, James F.;Burkard, Michael;Chan, Jocelyn;Chen, Huifen;Chou, Kang-Jye;Diaz, Dolores;Dudley, Danette A.;Gaudino, John J.;Gould, Stephen E.;Grina, Jonas;Hunsaker, Thomas;Liu, Lichuan;Martinson, Matthew;Moreno, David;Mueller, Lars;Orr, Christine;Pacheco, Patricia;Qin, Ann;Rasor, Kevin;Ren, Li;Robarge, Kirk;Shahidi-Latham, Sheerin;Stults, Jeffrey;Sullivan, Francis;Wang, Weiru;Yin, Jianping;Zhou, Aihe;Belvin, Marcia;Merchant, Mark;Moffat, John;Schwarz, Jacob B.. And the article was included in Journal of Medicinal Chemistry in 2016.Electric Literature of C5H9N3 This article mentions the following:

The extracellular signal-regulated kinases ERK1/2 represent an essential node within the RAS/RAF/MEK/ERK signaling cascade that is commonly activated by oncogenic mutations in BRAF or RAS or by upstream oncogenic signaling. While targeting upstream nodes with RAF and MEK inhibitors has proven effective clin., resistance frequently develops through reactivation of the pathway. Simultaneous targeting of multiple nodes in the pathway, such as MEK and ERK, offers the prospect of enhanced efficacy as well as reduced potential for acquired resistance. Described herein is the discovery and characterization of GDC-0994 (22), an orally bioavailable small mol. inhibitor selective for ERK kinase activity. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Electric Literature of C5H9N3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Electric Literature of C5H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics