pyrazoles-derivatives

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., SDS of cas: 25016-20-0

To a solution of 1 -methyl- 7/-/-pyrazole-3-carboxylic acid (0.100 g, 0.793 mmol), A/,A/-diisopropylethylamine (0.307 g, 2.38 mmol) in tetrahydrofuran (4 ml_) at 20 C was added 1 -[b/s(dimethylamino)methylene]- 7/-/-1 ,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (0.452 g, 1 .19 mmol). The reaction was stirred for 20 minutes before a solution of 5-(3-chlorobenzyl)pyridin-2-amine (0.173 g, 0.793 mmol) in tetrahydrofuran (1 .0 ml_) was added. The solution was stirred at 20 C for 16 h. The volatiles were removed under reduced pressure and the residue was added to a mixture of dichloromethane (50 ml_) and water (50 ml_). The organic layer was collected, dried over sodium sulfate, filtered and concentrated. The crude sample was dissolved in minimal A/,A/-dimethylformamide and purified via prep-HPLC (Boston C1 8 21 *250 mm 10 pm column; acetonitrile/0.01 % aqueous trifluoroacetic acid) to give A/-(5-(3-chlorobenzyl)pyridin-2-yl)-1 -methyl- 7/-/-pyrazole-3-carboxamide (0.0927 g, 0.285 mmol, 36%) as a white solid. 1 H NMR (400 MHz, Dimethylsulfoxide-c/6) d 9.51 (s, 1 H), 8.29 (s, 1 H), 8.1 0 (d, J = 10.5 Hz, 1 H), 7.88 (d, J = 2.5 Hz, 1 H), 7.71 -7.74 (m, 1 H), 7.23-7.35 (m, 4H), 6.84 (d, J = 2.5 Hz, 1 H), 3.96 (s, 5H); LCMS (ESI) m/z: 327.1 [M+H]+.

The synthetic route of 25016-20-0 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 118430-73-2, name is 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 118430-73-2

Pyrazole 5 (673 mg, 4.4 mMol), diisopropylethylamine (684 mg, 5.3 mMol, 1.2 eq.), and DCM (9 mL) were cooled to -10 C. and phenyl chloroformate (750 mg, 4.8 mMol, 1.1 eq.) was added in a single portion. The solution was allowed to warm to 0 C. and stir for 30 min. The solution was partitioned between ether and aqueous sodium bicarbonate and the ether layer was washed with brine. The organic fraction was dried over anhydrous sodium sulfate and the solvent removed in vacuo and the residue purified using silica gel chromatography eluting with ethyl acetate (5%-50%)/hexane. Solvent removal afforded the product (6) as brittle foam (1.0 g, 3.9 mMol, 90% yield), which provided a single peak by LC-MS analysis (M+H=274.1). 1H NMR (400 MHz, CDCl3) delta: 7.4 (dd, J=8.0, 7.6 Hz, 2H), 7.25 (tt, J=7.6 Hz, 1H), 7.18 (d, J=8.0 Hz, 2H), 6.95 (brs, 1H), 6.15 (s, 1H), 3.79 (s, 3H), 1.29 (s, 9H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 118430-73-2.

16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 16034-46-1

Oleum (1977mmol) is slowly added to fuming nitric acid (777 mmol) followed by the addition of 2-methyl-2H-pyrazole-3-carboxylic acid (277 mmol) in small portions maintaining the reaction temperature below 600C. Stirring at this temperature is then continued for a further 1 h. On completion, the reaction mixture is poured onto crushed ice and extracted with ethyl acetate (300 mL x 3). The combined organic phases are washed with water (250 mL x 2) and dried over anhydrous sodium sulfate. The solvent is removed under reduced pressure to afford 2-methyl-4-nitro-2H-pyrazole-3- carboxylic acid as a light yellow solid. Compound wt: 23.6g, 50%. [0234] 1H NMR (400 MHz, OMSO-d6) delta: 8.29 (lH,s); 3.95 (3H, s).

Statistics shows that 16034-46-1 is playing an increasingly important role. we look forward to future research findings about 1-Methyl-1H-pyrazole-5-carboxylic acid.

143426-52-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 143426-52-2 name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4 mmol of the compound IIIb was dissolved in 20 mL of acetonitrile, and intermediate 77 mmol and 8 mmol ofcesium carbonatewere added thereto at room temperature.After heating, the reaction was refluxed for 13 hours.The reaction was stopped, the reaction solution was rotary evaporated to dryness under reduced pressure, the resulting residue was purified by columnseparation and purification to give the title compound analysis Ib

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, and friends who are interested can also refer to it.

13808-64-5, Adding a certain compound to certain chemical reactions, such as: 13808-64-5, name is 4-Bromo-3-methylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13808-64-5.

To a solution of 4-bromo-3 -methyl- lH-pyrazole 1 (0.25 g, 1.55 mmol) indimethylformamide (DMF) (30 mL) was added NaH (0.08 g, 3.2 mmol). The mixture was stirred for 0.5 h at room temperature and 2-bromo-5-methyl-l,3-thiazole (0.33 g, 1.86 mmol) was added. The reaction mixture was stirred for 1 h at room temperature. The reaction temperature was raised to 90C and stirred overnight. The reaction was quenched with MeOH and solvent was removed in vacuo. The residue was treated with water and EtOAc. The organic layer was separated and aqueous was extracted with EtOAc. The combined organic phase was dried over Na2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 53 (0.2 g, 50%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-methylpyrazole, other downstream synthetic routes, hurry up and to see.

16209-00-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16209-00-0, name is 4-(1H-Pyrazol-1-yl)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

An aqueous solution was prepared by adding 4-(1H-pyrazole-1-yl)benzoic acid (0.085 g, 0.454 mmol) to water (50 ml). The complex (108) sulfate, namely, the [Cp*Ir(H2O)3]2+ sulfate, produced in Step 2 (0.20 g, 0.423 mmol) was added to this aqueous solution in an argon atmosphere, and the resultant mixture was heated to reflux for 12 hours in the dark. After the reflux, this solution was filtered through a membrane filter (manufactured by ADVANTEC, made of PTFE (polytetrafluoroethylene)). This filtrate was evaporated to remove moisture therefrom and then was vacuum-dried. Thus, desired iridium mononuclear aqua complex (13) sulfate, namely, [IrCp*(4-(1H-pyrazole-1-yl-kappaN2-)benzoic acid-kappaC3)(H2O)]+ sulfate, was obtained in the form of yellow powder (the yield calculated based on the sulfate of [Cp*Ir(H2O)3]2+/-: 94%). The instrumental analysis values of the [IrCp*(4-(1H-pyrazole-1-yl-kappaN2-)benzoic acid-kappaC3)(H2O)]+ sulfate are shown below. FIG. 22 shows the measurement results obtained by CV (cyclic voltammetry). In order to measure the elementary analysis values, the iridium mononuclear aqua complex (13) was converted to the above-described zero-valent complex (14), which was isolated by crystallization. These elementary analysis values also are shown in FIG. 17.1H-NMR (DMSO-d6, 298 K): delta (ppm) 1.75 (s, eta5-O5(CH3)5, 15H), 6.99 (d, d, J=2.2 Hz, J=2.7 Hz, 1H), 7.84 (d, d, J=8.4 Hz, J=1.5 Hz, 1H), 7.91 (d, J=8.4 Hz, 1H), 8.19 (d, J=1.5 Hz, 1H), 8.33 (d, J=2.2 Hz, 1H), 9.03 (d, J=2.7 Hz, 1H)Elementary analysis values: C20H23N2O3Ir: C, 45.18%; H, 4.36%; N, 5.27%Found: C, 44.90%; H, 4.30% N, 5.11%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Some common heterocyclic compound, 1018446-95-1, name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, molecular formula is C8H13N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1018446-95-1

Tert-butyl 4-amino-1H-pyrazole-1-carboxylate (24 mg, which was synthesized according to W02008/139161), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (21 mg), cesium carbonate (97 mg), and tris(dibenzylideneacetone)dipalladium (0) (16 mg) were added to a solution of the compound 0001-5 (40 mg) in 1,4-dioxane solution (1.2 mL), and the mixture was heated and refluxed for 2 hours under a nitrogen atmosphere. The reaction solution was returned to room temperature, water was added thereto, and the mixture was extracted with a chloroform-methanol mixed solvent. The organic layer was dried over sodium sulfate and the solvent was then evaporated under reduced pressure. To the obtained residue, dichloromethane (1.2 mL) and trifluoroacetic acid (0.18 mL) were added, and the mixture was stirred at room temperature for 6 hours. Then, a saturated aqueous sodium hydrogen carbonate solution was added to the reaction solution, and the mixture was extracted with a chloroform-methanol mixed solvent. The organic layer was dried over sodium sulfate, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform-methanol) to obtain a compound 0125 (18 mg) as a yellow solid. 1H-NMR (DMSO-d6) delta: 12.80 (1H, bs), 9.58 (1H, s), 9.51 (1H, bd), 8.42-8.41 (2H, m), 8.00 (1H, d), 7.85 (1H, bs), 7.53 (1H, bs), 7.12 (1H, d), 7.03 (1H, d), 4.14-4.03 (1H, m), 1.93-1.46 (8H, m). MS m/z (M+H): 338.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1018446-95-1, its application will become more common.

52867-42-2, A common compound: 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

In a three-necked round bottom flask were successively added acetone 20mL, methyl 3-hydroxy-1-methylpyrazole-5-carboxylate 5mmol, 1,1,3_ trichloropropene 5.5mmol alkaline conditions at room temperature for 12h, filtered , Acetone, and concentrated to give methyl 3- (3,3-dichloroallyloxy) -1-methylpyrazole-5-carboxylate as a white solid in 95% yield, purity 95%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 14531-55-6

To a solution of 3,5-dimethyl-4-nitro-1H-pyrazole (1.09, 7.09 mmcl) in acetonitrile (10 mL)was added 2,2-dimethyloxirane (1.788 g, 24.80 mmol) and DBU (2.136 mL, 14.17 mmol).The reaction was stirred at 60 C for 20 hours. The mixture was quenched with water and extracted with DCM (20 mL x 3). The combined organic layer was dried over Na2SO4, filtered and concentrated in vacuum. The crude was purified by column chromatography on silica gel (DCM: MeOH2O:1) to give the title compound D5 (800 mg, 3.75 mmol,52.9 %yield).LCMS: 214 [M+H], tRl.O6 mi (LCMS condition 2)

The synthetic route of 14531-55-6 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 1001020-14-9, name is 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1001020-14-9

Example 862-(3-(4-((Methylamino)methyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl)propanamido)-4,5,6,7- tetrahydrobenzofblthiophene-3-carboxamidea) 2-(3-(4-Formyl-3-(trifluoromethyl)-1 H-pyrazol-1 -yl)propanamido)-4,5,6,7- tetrahydrobenzo[b]thiophene-3-carboxamide3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde (260 mg, 1.585 mmol) and 2-(3- chloropropanamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (454 mg, 1.585 mmol) were dissolved in THF (20 mL). Potassium tert-butoxide (356 mg, 3.17 mmol) was added followed by potassium iodide (10 mg, 0.06 mmol). The reaction mixture was stirred at RT overnight. Water was added and the reaction mixture extracted with EtOAc (x 3).The EtOAc layers were combined and washed with brine, dried over MgSO4, filtered and the solvent removed in vacuo to give a yellow gum (673 mg). Purification by flash column chromatography-silica gel gave the desired product as a white solid (180 mg, 0.43 mmol,27 %).MS (ESI) : m/z 415.1 [M + H]+ .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1001020-14-9.