Tag: 200-300

Synthesis of N-Methoxy-N-methyl-β-enaminoketoesters: New synthetic precursors for the regioselective synthesis of heterocyclic compounds. [Erratum to document cited in CA145:271693] was written by Persson, Tobias;Nielsen, John. And the article was included in Organic Letters in 2007.Recommanded Product: Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

In the Supporting Information section, on page S6, “1 M aq HC1 (5 mL)” should read “1 M aq HC1 (2 mL)”. A corrected Supporting Information file has been posted online. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Recommanded Product: Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product class 1: pyrazoles was written by Stanovnik, B.;Svete, J.. And the article was included in Science of Synthesis in 2002.Synthetic Route of C18H16N2O2 The following contents are mentioned in the article:

A review. Methods for preparing pyrazoles are reviewed including cyclization, ring transformation, aromatization and substituent modifications. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Synthetic Route of C18H16N2O2).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Synthetic Route of C18H16N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Haloacetylated enol ethers. 11. Synthesis of 1-methyl- and 1-phenyl pyrazole-3(5)-ethyl esters. A one-pot procedure was written by Martins, Marcos A. P.;Freitag, Rogerio A.;Da Rosa, Adriano;Flores, Alex F. C.;Zanatta, Nilo;Bonacorso, Helio G.. And the article was included in Journal of Heterocyclic Chemistry in 1999.Product Details of 17355-75-8 The following contents are mentioned in the article:

Me and phenylpyrazole Et esters I [R = Me, Ph; R¹ = Me, Ph, EtO₂C; R² = H, Me; R¹R² = (CH₂)₄; R³ = EtO₂C, Me, Ph; R²R³ = (CH₂)₄] are prepared by the cyclocondensation of β-alkoxyvinyl trichloromethyl ketones II [R⁴ = Me, Et; R⁵ = Me, Ph; R⁶ = H, Me; R⁵R⁶ = (CH₂)₄] with Me and Ph hydrazine hydrochloride in a one-pot reaction under mild conditions in 60-89% with a variety of enol ethers. Effects of hydrazine and β-alkoxyvinyl trichloromethyl ketone substituents on the regiochem. of pyrazole cyclization were observed This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Product Details of 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Product Details of 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis, characterization, and fluorescence properties of a novel symmetric di-nuclear b-diketonate ligand and its Eu³⁺ ternary chelate complex was written by Yang, Qing;Tang, Rui-ren. And the article was included in Xuzhou Gongcheng Xueyuan Xuebao, Ziran Kexueban in 2013.Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

A novel β-diketonate ligand: 2,6-Bis(3-methyl-1-phenyl-5-pyrazolone-4-yl) pyridine was prepared and characterized by elemental anal. and 1 H NMR spectra. The result of the 1H NMR spectroscopy showed that the ligand L existed as an enol form isomer, which was consistent with the result of IR anal. In addition, its corresponding dinuclear Eu³⁺ complex using 1,10-phenanthroline as the second ligand was prepared and characterized by elemental anal., IR spectra, UV-Vis spectra, and 1 H NMR. The fluorescence spectra indicated that the ligand had excellent antenna effect to sensitize the Eu³⁺ ions, and the emission spectra was very sharp and narrow, which would be considered as a valuable material in organic electroluminescence materials. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of bromodifluoromethyl substituted pyrazoles and isoxazoles was written by Yang, Xueyan;Shui, Shengxia;Chen, Xi;He, Haiou;Wu, Fanhong. And the article was included in Journal of Fluorine Chemistry in 2010.Reference of 17355-75-8 The following contents are mentioned in the article:

Bromodifluoromethyl substituted pyrazoles I (R¹ = Ph, 4-MeC₆H₄, etc.; R² = Ph, 4-O₂NC₆H₄, etc.) were prepared regioselectively by the reaction of the corresponding ketones with Et bromodifluoroacetate in the presence of sodium methoxide followed by cyclocondensation of the intermediate β-diketones R¹C(O)CH₂C(O)CF₂Br with aryl hydrazines R²NHNH₂. The reaction of R¹C(O)CH₂C(O)CF₂Br with hydroxylamine hydrochloride gave dihydroisoxazoles, which afforded bromodifluoromethyl substituted isoxazoles II by dehydration with PPA or concentrated sulfuric acid. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Reference of 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Reference of 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Preparation of 1,3,5-trisubstituted pyrazoles with cascade reaction catalyzed by Cu between hydrazonoyl halide and terminal alkynes was written by Li, Fuwei;Wang, Xiaolong;Yu, Haitao. And the article was included in Youji Huaxue in 2016.Application of 17355-75-8 The following contents are mentioned in the article:

Cascade reaction, including nucleophilic substitution and addition cyclization, catalyzed by Cu⁺ salt between substituted aryl hydrazonoyl halides and terminal alkynes could produce 1,3,5-trisubstituted pyrazoles. The method employed easily available aryl hydrazonoyl halide and terminal alkynes as starting materials under 45°C in green acetonitrile/water solvent, regioselectively generating 1,3,5-trisubstituted pyrazoles in high yield. Above all, functional groups containing active hydrogen would not disturb this reaction, example for carboxyl and hydroxyl. In this work, 17 pyrazole derivatives with different substituent group were achieved by this method. So it could be a general method to synthesize 1,3,5-trisubstituted pyrazoles. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Application of 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application of 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

New COX-2/5-LOX Inhibitors: Apoptosis-Inducing Agents Potentially Useful in Prostate Cancer Chemotherapy was written by Pommery, Nicole;Taverne, Thierry;Telliez, Aurelie;Goossens, Laurence;Charlier, Caroline;Pommery, Jean;Goossens, Jean-Francois;Houssin, Raymond;Durant, Francois;Henichart, Jean-Pierre. And the article was included in Journal of Medicinal Chemistry in 2004.HPLC of Formula: 17355-75-8 The following contents are mentioned in the article:

The arachidonic acid metabolizing enzymes cyclooxygenase-2 (COX-2) and lipoxygenases (LOXs) have been found to be implicated in a variety of cancers, including prostate cancer. To develop new therapeutic treatments, it therefore seemed interesting to design dual COX-2/5-LOX inhibitors. We report here the synthesis and in vitro pharmacol. properties of diarylpyrazole derivatives that have in their structure key pharmacophoric elements to obtain optimal interaction with subsites of active pockets in both enzyme systems. Using a mol. modeling approach, a set of SAR data is proposed, highlighting the importance of the sulfonyl group of one of the aryl moieties in terms of proliferation inhibition and/or apoptosis induction. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8HPLC of Formula: 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. HPLC of Formula: 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles prepared from phosphorus ylides was written by Fusco, Raffaello;Dalla Croce, Piero. And the article was included in Chimica e l’Industria (Milan, Italy) in 1970.Related Products of 17355-75-8 The following contents are mentioned in the article:

I are prepared from RCOCH:PPh3 (II) and ArN-N:C+R1 (III). IV are also prepared Thus, 0.5 mole III in 50 ml CHCl3 are added to solutions of 0.1 mole II in 100 ml CHCl3 containing 0.15 mole Et3N and the mixtures arerefluxed 4 hr to give 79% 1,5-diphenyl-3-carbethoxypyrazole, m. 82°, and the following I (Ar = Ph) (R, R1, m.p., and % yield given): Me, CO2Me, 56°, 60; CO2Et, CO2Et, 79°, 20; OEt, CO2Et, 85°; 86; NMe2, CO2Me, 65°, 40. II are treated with III in the presence of Et3N at room temperature to give IV (Ar = p-O2NC6H4), m. 150°, and IV (Ar = o-O2NC6H4), m. 200°, which are heated with Et3N to give the following I (R = OEt, R1 = CO2Et) (Ar and m.p. given): p-O2NC6H4, 132°; o-O2NC6H4, 130°. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Related Products of 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Related Products of 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

La(OTf)₃-catalysed one-pot synthesis of pyrazole tethered imidazo[1,2-a]azine derivatives and evaluation of their light emitting properties was written by Sharma, Shubham;Paul, Avijit Kumar;Singh, Virender. And the article was included in New Journal of Chemistry in 2020.SDS of cas: 17355-75-8 The following contents are mentioned in the article:

A facile and efficient protocol has been unfolded towards the diversity-oriented synthesis of highly fluorescent pyrazole C-3(5) tethered imidazo[1,2-a]azines via an La(OTf)₃ catalyzed one-pot multicomponent assembly of pyrazole carbaldehydes, 2-aminoazines and isonitriles. This present protocol offers several advantages such as multiple bond formation in a single step, low catalyst loading, short reaction time, appreciable atom economy, good functional group tolerance, scalability and easy to perform reaction conditions. The optical properties of pyrazolyl imidazo[1,2-a]azines were also studied, and they exhibited an excellent fluorescence quantum yield (Φ_F up to 83%). This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8SDS of cas: 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.SDS of cas: 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pd-Catalyzed Late-Stage Monoacetoxylation and Monoiodination of 4-Alkyl-1,5-diaryl-1H-pyrazole-3-carboxylates via Direct Csp²-H Bond Activation was written by Fan, Xue-Min;Guo, Ying;Li, Yu-Dan;Yu, Kun-Kun;Liu, Hong-Wei;Liao, Dao-Hua;Ji, Ya-Fei. And the article was included in Asian Journal of Organic Chemistry in 2016.HPLC of Formula: 17355-75-8 The following contents are mentioned in the article:

A palladium-catalyzed, late-stage functionalization of 4-alkyl-1,5-diaryl-1H-pyrazole-3-carboxylates to achieve acetoxylation or iodination via Csp²-H bond activation with synthetically useful to excellent yields was described. These straightforward transformations featured highly functionalized substrates, excellent site selectivity, rapid reaction and simple operation. The C-O and C-I bond-forming protocols allowed convenient accesses to lots of complex monoacetoxylated and monoiodinated products from pharmaceutically important intermediates. Iodoacetic acid was also used as the iodinating agent in C-H bond activation. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8HPLC of Formula: 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.HPLC of Formula: 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics