pyrazoles-derivatives

These common heterocyclic compound, 930-36-9, name is 1-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 930-36-9

Adding 5.92 g (20 mmol) of FeBr3 to a solution of 8.2 g (100 mmol) of 1-methylpyrazole dissolved in 100 mL of methyl tert-butyl ether at 0 ;Under stirring, 32 g (200 mmol) of Br2 was added dropwise.Stir at room temperature,The end of the reaction was followed by TLC.After confirming the reaction,Filter the system,The filtrate is poured into the water.Use Na2S2O3 solution in sequence,Water washing,Liquid separation.The obtained organic phase was dried over anhydrous magnesium sulfate.The solvent was evaporated under reduced pressure,Got 14.5g(yield: 90.5%, purity 98%)5-bromo-1-methylpyrazole.

The synthetic route of 1-Methylpyrazole has been constantly updated, and we look forward to future research findings.

Related Products of 852227-86-2, These common heterocyclic compound, 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred suspension of10(30 mg, 0.07 mmol) and potassium carbonate (20 mg, 0.15 mmol) in DMF (500 muL) was added 2-bromoacetamide (15 mg, 0.11 mmol) and the mixture heated to 80 C for 1 h. The reaction mixture was concentrated to dryness and 4 MHCl/dioxane (1 mL) added. After concentrating to dryness, the residue was purified by prepHPLC(high pH) to afford the title compound(8 mg, 30%) as a white powder.

Statistics shows that 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 852227-86-2.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, A new synthetic method of this compound is introduced below., COA of Formula: C4H6N2O

General procedure: 5-Amino-4-arylazo-3-methyl-1-phenylpyrazoles (0.01 mol) weredissolved in a mixture of glacial acetic acid and concentrated hydrochloricacid (20 ml, ratio 1:1) and the solutionwas then cooled to 0-5 C. Sodiumnitrite (0.69 g, 0.01 mol) in water (10 ml) was then added to this solution dropwise with vigorous stirring, for about 1 h, while cooling at0-5 C. Then the resulting diazonium solution was added in portionsover 30 min to a vigorously stirred solution of 5-hydroxy-3-methyl-1H-pyrazole or 5-hydroxy-3-methyl-1-phenylpyrazole (0.01 mol) in KOH (0.56 g, 0.01mol) andwater (10ml) between 0 and 5 C,maintainingthe pHat 7-8 by simultaneous sodiumacetate solution addition. The mixture was then stirred for 2 h at 0-5 C. The precipitated product separated upon dilution with water (50 ml) was filtered off, washed with water several times, dried and crystallized from DMF-H2O

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 1192-21-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows.

Step 1: A clean 100 L cylindrical reaction vessel was charged with THF (13 kg) then (S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one (I, 5 kg) and 1-methyl-1H-pyrazol-5-amine (1.1 kg) were added sequentially with medium agitation followed by THF (18 kg). The mixture was cooled to ?35¡ã C. and to the resulting thin slurry was added slowly a THF solution of LiHMDS (17.4 kg, 1.0 M) at a rate that maintained the internal temperature below ?25¡ã C. After the addition was completed, the reaction was held between ?35 and ?25¡ã C. for 20 min and monitored by HPLC. If the HPLC result indicated ?98.5percent conversion, additional LiHMDS (0.34 kg, 1.0 M, 0.05 mol percent) was added slowly at ?35¡ã C. The reaction was quenched slowly at the same temperature with H3PO4 solution (4.4 kg of 85percent H3PO4 and 15 kg of water) and the internal temperature was kept below 30¡ã C. The reaction was diluted with EtOAc (18 kg) and the phases separated, the organic layer was washed with H3PO4 solution (1.1 kg of 85percent H3PO4 and 12 kg of water) followed by a second H3PO4wash (0.55 kg of 85percent H3PO4 and 12 kg of water). If 1-methyl-1H-pyrazol-5-remained, the organic layer was washed again with H3PO4 solution (0.55 kg of 85percent H3PO4 and 12 kg of water). Finally the organic layer was washed sequentially with water (20 kg) and a NaCl and NaHCO3 solution (2 kg of NaCl, 0.35 kg of NaHCO3 and 10 kg of water). After the phase separation, residue water in organic solution was removed through an azeotropic distillation with EtOAc to <0.5percent (by KF) and then solution was concentrated to 20-30 L under a vacuum below 50¡ã C. The solvent was then swapped to MeOH using 35 kg of MeOH and then concentrated to between 20 and 30 L for the next step. The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-5-amine. I believe this compound will play a more active role in future production and life.

Related Products of 35344-95-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

Preparation of (lR, 4R)-N1-((lH-prazol-4-l)methl)-N4-(4-(5- (cvclopropylmethyl)-l-methyl-lH-pyrazol-4-yl)pyrimidin-2-yl)cvclohexane-l,4- diamine (A80) To a solution of A-14 (200.00 mg, 612.67 mupiiotaomicron, 1.00 eq) and lH-pyrazole-4- carbaldehyde (58.87 mg, 612.67 muetaiotaomicron, 1.00 eq) were added AcOH (36.79 mg, 612.67 02429524H5-01 muetaiotaomicron, 35.04 uL, 1.00 eq) and NaBH3CN (77.00 mg, 1.23 mmol, 2.00 eq). The mixture was sitrred at 15 ¡ãC for 16 hours. The mixture was quenched with aqueous NaHCCb (1 mL) and concentrated. The residue was purified by prep-HPLC (basic condition) to give A-80 (20.00 mg, 48.90 muiotaetaomicron, 8percent yield, 99.4percent purity) as a yellow solid. LCMS: RT = 2.418 min, m/z 407.2 [M+H]+ NMR (CDCb, 400 MHz) delta 8.17 (d, /=5.2Hz, IH), 7.83 (s, IH), 7.58 (s, IH), 6.71 (d, /=6.2Hz, IH), 4.88 (d, /=7.6Hz, IH), 3.89 (s, 4H), 3.81 (s, 2H), 3.21 (d, /=6.0Hz, 2H), 2.61 (s, IH), 2.21-2.03 (m, 4H), 1.36-1.25 (m, 4H), 1.09 (s, IH), 0.48-0.46 (m, 2H), 0.25-0.24 (m, 2H).

The chemical industry reduces the impact on the environment during synthesis 1H-Pyrazole-4-carbaldehyde. I believe this compound will play a more active role in future production and life.

Related Products of 1353100-91-0,Some common heterocyclic compound, 1353100-91-0, name is Ethyl 3-bromo-1H-pyrazole-4-carboxylate, molecular formula is C6H7BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0500] to a solution of NAH (1.64 g, 41.09 mmol, 60% purity) in THF (80 ml) at 0 C was added a solution of compound 30b (6 g, 27.39 mmol) in THF (20 ml). After addition, the mixture was warmed up to 25 C and stirred for 2 hrs. Then the solution was cooled to 0 C and a solution of sem-c1 (5.34 ml, 30.13 mmol) in THF (100 ml) was added at 0 C. The mixture was then warmed up to 25 C and stirred for 12 hrs. The reaction was quenched with H2O (100 ml) dropwise. The mixture was extracted with EtOAc (100 ml x 2). The organics were collected and concentrated. The residue was purified by column (petroleum ether: ethyl acetate = 10: 1) to afford compound 30c (3 g, yield: 31.14%) as yellow oil.

The synthetic route of 1353100-91-0 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15953-45-4, name is 5-Chloro-3-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H5ClN2

(b) S-Chloropyrazole-S-carboxylic acidA mixture of 5-chloro-3-methylpyrazole (3.6 mmol; see step (a) above), water (6 mL) and fert-butanol (1.2 mL) was heated to 750C, after which KMnO4 (1.42 g, 9 mmol) was added. The mixture was stirred at 75 C overnight and filtered hot. The solids were washed with boiling water. The combined cooled filtrates were extracted with EtOAc, and the combined extracts washed with NaCl (sat., aq.), dried (MgSO4) and concentrated. The crude solid was recrystallised from EPO EtOAc/hexane/pentane to give the sub-title compound as white crystals (Yield:350 mg (67%)).1H-NMR (DMSO-d6, 400 MHz), delta 13.65 (br s, IH), 6.80 (s, IH)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15953-45-4.

Application of 35100-92-6,Some common heterocyclic compound, 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The final product 03 (30 mg, 0.0927 mmol), 1,5-dimethyl-1H-pyrazole-3-amine (31 mg, 0.278 mmol) and Et3N (38 mg, 0.376 mmol) were weighed into a bottle, and 2 mL of DMF was added to dissolve Reaction reagent.The reaction was heated at 50 C overnight.The crude reaction product was directly purified by reverse-phase HPLC to obtain the target compound YB152 (54.7 mg).

The synthetic route of 35100-92-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1H-Pyrazole-4-carbaldehyde

Sodium hydride (60percent, 6.3 g, 1.0 eq) was added to a solution of 1H-pyrazole-4-carbaldehyde (15 g, 156 mmol) in DMF (150 ml) at 0¡ã C. The mixture was allowed to warm and was stirred at room temperature. (2-Bromoethoxy)benzene (30.2 g, 1 eq) was then added and the resulting mixture was stirred overnight at room temperature. It was quenched by addition of aqueous ammonium chloride, diluted with water and extracted with EtOAc. The combined organic layers were dried over Na2SO4, filtered, and concentrated. The residue was purified by column chromatography using a hexane/ EtOAc gradient (10:1 to 0:100). Pure fractions were combined and evaporated under reduced pressure to yield 1-(2-phenoxyethyl)-1H-pyrazole-4-carbaldehyde (24 g, 71percent).

According to the analysis of related databases, 35344-95-7, the application of this compound in the production field has become more and more popular.

Reference of 943541-20-6,Some common heterocyclic compound, 943541-20-6, name is 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, molecular formula is C8H7ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 13: A route to prepare compound (I)6-{difluoror6-(1-methvl-1 H-pvrazol-4-vl)? ,2,41triazolor4,3-lpvridazin-3-vnmethvl>quinolineStep 1 : tert-butyl 2-f6-(1-methyl-1 H-pyrazol-4-yl)pyridazin-3-vnhvdrazinecarboxylatetert-butyl carbazate, 8,98g (67,3 mmol) and 3-chloro-6-(1-methyl-1 /-/-pyrazol-4- yl)pyridazine (11 ,9 g, 61 ,1 mmol) were mixed in 1-butanol (245 ml_). This mixture was heated till 900C and stirred at that temperature for 16h. The reaction mixture was cooled and water (250 ml_) and ethylacetate (250 mL) were added. The biphasic mixture was neutralised with sodium hydrogencarbonate till the pH is 7. Then the organic layer was separated and the water layer was extracted with ethylacetate (250 mL). The combined organic layers were washed once with water (250 mL) and evaporated. The residue was stirred in isopropylether, filtered off and dried under vacuum. Yield: 5,9 g (20,3 mmol; 33%) of the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, its application will become more common.