pyrazoles-derivatives

Application of 330792-70-6,Some common heterocyclic compound, 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0110] Under nitrogen atmosphere, a mixture of toluene (8.0 v), AcOH (0.5 v), BG-8 (1.2 eq.) and BG-4 (66.9 Kg 1.0 eq.) was heated to 95C and stirred until the reaction was completed. The mixture was cooled, concentrated and precipitated from methanol. The mixture was centrifuged and the cake was washed with methanol. The cake was dried under vacuum. This gave 107.8 Kg of product.1H NMR (DMSO-de) delta 8.78 (d, J= 4.6 Hz, 1H), 8.15-8.07 (m, 2H), 7.51-7.41 (m, 2H), 7.34 (d, J= 4.6 Hz, 1H), 7.27-7.19 (m, 3H), 7.17-7.10 (m, 2H), 4.24-4.02 (m, 2H), 3.81-3.69 (m, 1H), 3.12-3.82 (m, 2H), 2.15-2.04 (m, 2H), 1.76-1.60 (m, 2H), 1.43 (s, 9H).

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.

Related Products of 3994-50-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3994-50-1 as follows.

General procedure: To a 8 mL glass vial equipped with a magnetic stirbar were sequentially added K2CO3 (207 mg, 1.5 mmol), the nitroazole substrate (0.50 mmol), aryl halide (0.50 mmol oras indicated), toluene (0.50 M or 1.0 M), Pd(OAc)2 (5.60mg, 0.025 mmol) and [PCy3H]BF4 (18.4 mg, 0.050 mmol).The reaction mixture was purged with nitrogen through aTeflon-lined cap. Then the cap was replaced with a newTeflon-lined solid cap. The reaction vial was moved to a preheatedreaction block. After stirring for 18 h at the indicatedtemperature, the reaction mixture was cooled to 25 C and concentrated. The residue was purified by flash column chromatography to provide the desired arylated product.

According to the analysis of related databases, 3994-50-1, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 180207-57-2, Quality Control of 2-(1H-Pyrazol-4-yl)ethanol

A solution of 2-(1H-pyrazol-4-yl)ethan-1-ol (3.00 g, 26.75 mmol, 1.00 equiv), SEM-Cl (7.00 mL, 43.18 mmol, 1.61 equiv) and Cs2CO3 (13.00 g, 39.89 mmol, 1.49 equiv) in N,N-dimethylformamide (20 mL) was stirred for 3 h at room temperature. When LCMS indicated most of starting material was converted into the desired product, the resulting solution was concentrated and diluted with 150 mL of dichloromethane, washed with 3×50 mL of brine, dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by a silica gel column eluting with DCM/MeOH (10:1) to afford 2.6 g of the title compound as yellow oil.

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 158001-28-6, name is 5-Amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Formula: C8H12N4

To 5-amino-1-tert-butyl-1H-pyrazole-4-cyano (1.1g, 6.75mmol) was added formamide (15mL), heated to reflux for 6 hours to obtain a reaction solution, the reaction solution was treated with ethyl acetate The ester (3¡Á30mL) was extracted, and the resulting organic layer was dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated under reduced pressure to obtain a brown solid (0.97g, 5.1mmol) (yield 76%).

The synthetic route of 158001-28-6 has been constantly updated, and we look forward to future research findings.

1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate

Under N2 protection and a condition free of water and oxygen, Intermediate 2 (604 mg, 2.87 mmol) wasdissolved in tetrahydrofuran (20 ml), which was cooled to 0C, and sodium hydride (180 mg, 60 wt%, 4.5 mmol) wasadded, followed by stirring for 30 min. Cyclopropylsulfonyl chloride (1.27 g, 9.0 mmol) was added dropwise, and thetemperature was allowed to rise spontaneously to room temperature, followed by reaction for 1 hour. The reaction was quenched by addition of water (20 ml) to the reaction solution, which was then extracted with ethyl acetate (20 ml32).The organic phases were combined, dried over anhydrous sodium sulfate, concentrated, re-dissolved in 5 ml tetrahydrofuran,and cooled to -10C to 0C. Potassium t-butoxide (36 mg, 0.32 mmol) was added, and the reaction was allowedto proceed for 28 hours at this temperature. After the reaction was completed, an aqueous solution of citric acid (1 ml,15%) was added, and water (10 ml) was added. The solution was extracted with ethyl acetate (20 mL33). The organicphases were combined, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gelcolumn chromatography (petroleum ether/ethyl acetate (v/v) = 2:1) to obtain a white solid 1a (660 mg, yield 73%).

The synthetic route of 1280210-79-8 has been constantly updated, and we look forward to future research findings.

Related Products of 1190380-49-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190380-49-4 name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 100 ml flask were added methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate (309 mg, 1.4 mmol), 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-amine (234 mg, 1.4 mmol), 10 ml of acetonitrile and DIPEA (0.54 g, 4.18 mmol). The reaction mixture was stirred at 40 C. for 1 h, acetonitrile was evaporated under reduced pressure and then 30 ml of EtOAc was added. The mixture was washed with 60 ml of water and 30 ml of brine. The organic phase was dired and concentrated to give 405 mg of intermediate 7a as a grey solid. MS m/z (ESI): 352.1[M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, and friends who are interested can also refer to it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C12H12N2O3

(Step 6) 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid[3-fluoro-4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenyl]-amide; 3-Fluoro-4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenylamine (80 mg, 0.25 mmol), 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (72 mg, 0.31 mmol) and HATU (190 mg, 0.5 mmol) were dissolved in dimethylformamide (3 mL). After adding triethylamine (0.04 mL, 0.5 mmol), the mixture was heated at 50 C. for 7 hours. The resulting reaction mixture was extracted with dichloromethane and water. The organic layer was washed with sodium chloride aqueous solution, dried with magnesium sulfate, and then filtered. The filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (hexane:ethyl acetate=1:1) to give the target compound as a white solid (12 mg, 0.02 mmol, 9% yield).1H NMR (400 MHz, DMSO): 12.29 (br s, 1H), 10.95 (br s, 1H), 8.08 (d, J=5.6 Hz, 1H), 7.98 (d, J=2.4, 1H), 7.94 (m, 2H), 7.60 (m, 2H), 7.52 (m, 1H), 7.46 (m, 4H), 7.33 (m, 3H), 6.89 (d, J=2.0 Hz, 1H), 6.35 (d, J=5.6, 1H), 3.38 (s, 3H), 2.71 (s, 3H). MS (ESI pos. ion) m/z: 534, Calc’d exact mass for C31H24FN5O3: 533.55.

The synthetic route of 83-10-3 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1120-82-7

1,4-bis(pyrazol-1-ylmethyl)-7-ethyl-1,4,7-triazacyclononane (L3) The ligand can be synthesised by heating 20 mmol Et-tacn (3.10 g), 40 mmol pyrazolylmethanol (3.92) (ref W. Driessen, Recl. Trav., Chim. Pays-Bas, 101, 441, 1982) and 0.4 g LiOH in 50 ml acetonitril for 20 hours under back-flow and argon atmosphere. The solution is filtered and the solvent is rotated off. The product has the form of a bright yellow oil. Yield: 6.3 g (80%). 1H-NMR (CDCl3- 400 MHz; 300K): 7.43 (d; 4H); 6.21 (s; 2H); 4.93 (s, 4H); 2.83(m; 8H); 2.62 (m; 4H); 2.53 (q; 2H); 0.95 (t, 3H); 13C-NMR: 139.0; 129.3; 125.9; 72.6; 54.3; 53.5; 52.7; 51.7; 12.3 ppm. MS (EI): m/z: 317.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1120-82-7.

Electric Literature of 2820-37-3, A common heterocyclic compound, 2820-37-3, name is 3,4-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 63 N,N,alpha,3,4-Pentamethylpyrazole-1-acetamide and N,N,alpha,4,5-pentamethylpyrazole-1-acetamide Following the procedure of Example 36, Part B, but substituting 3,4-dimethylpyrazole for 4-bromo-3-isopropylpyrazole, there was prepared N,N,alpha,3,4-pentamethylpyrazole-1-acetamide having a boiling point at 77 C. at 0.03 mm Hg.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 2075-45-8, name is 4-Bromo-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2075-45-8, SDS of cas: 2075-45-8

4-bromopyrazole (22.0 g) was dissolved in DMF (75 mL)Add K2CO3 (51.8 g, 2.5 eq) andDimethylaminoethane hydrochloride,And then reacted at room temperature for two days.Was added to EA (500 mL) and then washed successively with water and saturated brine, dried over Na2SO4 and subjected to column chromatography (1-20% MeOH / DCM) to give 36 (21.85 g, 66.5%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-pyrazole, and friends who are interested can also refer to it.