pyrazoles-derivatives

Reaction of hydrazine hydrate with 4-alkyl-1-cyanoacetylthiosemicarbazides was written by O’Callaghan, C. N.. And the article was included in Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science in 1976.Quality Control of 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:

NCCH2CONHNHCSNHR (R = Me, Et, Pr, PhCH2) were cyclized by H2NNH2.H2O at 20° to cyanomethyltriazolinethiones I, which at higher temperature were converted to II. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Quality Control of 3,5-Dimethyl-1H-pyrazole-1-carboxamide).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Quality Control of 3,5-Dimethyl-1H-pyrazole-1-carboxamide

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A new synthesis of azopyrazoles by oxidation of C-aminopyrazoles on a NiO(OH) electrode was written by Lyalin, Boris V.;Sigacheva, Vera L.;Kokorekin, Vladimir A.;Petrosyan, Vladimir A.. And the article was included in Mendeleev Communications in 2015.Recommanded Product: 3528-58-3 This article mentions the following:

Oxidation of C-amino-N-alkylpyrazoles on a NiO(OH) electrode in an aqueous alk. medium afforded the corresponding azopyrazoles. The success in implementation of these processes was due to the structure of C-aminopyrazoles. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Recommanded Product: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Equilibrium nitrogen acidity of nitrogen heterocycles was written by Terekhova, M. I.;Petrov, E. S.;Rokhlina, E. M.;Kravtsov, D. N.;Shatenshtein, A. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1979.Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

The acid pK values of 18 heterocycles were determined in Me₂SO by spectral observation of the transmetalation equilibrium with indicator CH acids. The pK values ranged from 23.3 for pyrrole to 7.8 for 2,4,5-tribromoimidazole. The pK decreased as the number of N atoms in the ring and the number of annulated benzene rings increased. LFER between pK and Σσ_m were found for imidazoles and pyrazoles. The pK were lower in MeOCH₂CH₂OMe than in Me₂SO. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Enaminone-derived pyrazoles with antimicrobial activity was written by Bhat, Mashooq Ahmad;Al-Omar, Mohamed A.;Naglah, Ahmed M.;Khan, Abdul Arif. And the article was included in Journal of Chemistry in 2019.Recommanded Product: 73387-46-9 This article mentions the following:

A series of pyrazoles I [R = 4-methoxy, 4-bromo, 4-morpholino, etc.; R¹ = H, 2-phenylacetyl] derived from the substituted enaminones were synthesized and were evaluated for antimicrobial activity. All the compounds were characterized by the spectral data and elemental anal. Thesynthesized compounds were initially screened for their antimicrobial activity against ATCC 6538, NCTC 10400, NCTC 10418 and ATCC 27853. During initial screening, compounds I [R = 2,4,6-trimethoxy; R¹ = H, R = 2,4-dimethoxy; R¹ = H, R = 4-bromo; R¹ = H] presented significant antimicrobial activity through disk diffusion assay. These compounds were further evaluated for antimicrobial activity at different time points against Gram-pos. and Gram-neg. bacteria and presented significant activity for 6h. The activity was found to be greater against Gram-pos. bacteria. In contrast at 24h, the activity was found only against Gram-pos. bacteria except compound I [R = 4-bromo; R¹ = H], showing activity against both types of bacteria. Compound I [R = 4-bromo; R¹ = H] was found to have highest activity against both Gram-pos. and Gram-neg. bacteria. In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9Recommanded Product: 73387-46-9).

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Recommanded Product: 73387-46-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Facile and environmentally friendly synthesis of nitropyrazoles using montmorillonite K-10 impregnated with bismuth nitrate was written by Ravi, P.;Tewari, Surya P.. And the article was included in Catalysis Communications in 2012.Recommanded Product: 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:

Nitropyrazoles in higher yields were synthesized using montmorillonite K-10 impregnated with bismuth nitrate and the present procedure may be applied for the nitration of a wide variety of azoles in the drug and pharmaceutical industries. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Recommanded Product: 3-Methyl-4-nitro-1H-pyrazole).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Recommanded Product: 3-Methyl-4-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Simultaneous determination of N-unsubstituted and N-substituted nitroazoles and criteria for their identification. II. Chromatographic separation and polarographic determination of nitropyrazoles was written by Dumanovic, D.;Maksimovic, R.;Ciric, J.;Jeremic, D.. And the article was included in Talanta in 1974.Reference of 54210-32-1 This article mentions the following:

The N-unsubstituted nitropyrazoles have an imino H atom (in contrast to the N-substituted derivatives) and react with OH-to give nitropyrazole anions. The strongly neg. shift of E1/2 for these anions allows simultaneous polarog. determination of any pair of compounds, 1 of which is an N-unsubstituted nitropyrazole and the other a corresponding N-substituted derivative Simultaneous polarog. determination of 3 compounds [3(5)-, 3- and 5-nitropyrazoles] is also possible with 0.1M NaOH as supporting electrolyte, but only when the shift ΔE1/2 between the N-substituted isomers is ≥ 100 mV. In this case, the adequate ΔE1/2 is a result of the different electron ds. of the NO2 groups of the isomers. In the mentioned medium it is possible to determine simultaneously even 4 compounds [1-, 3(5)-, 3-and 5-nitropyrazoles], because the E1/2 value of 1-nitropyrazole does not change with pH, unlike that of other nitropyrazoles. Developers for the thin-layer chromatog. separation are proposed. Some criteria are given for distinguishing between the N-unsubstituted and the corresponding N-substituted nitropyrazoles. The structures of 2 new compounds were determined Methods are recommended for the simultaneous identification and determination of the compounds appearing together in the reaction mixtures during the substitution of the imino H atom or during the rearrangements of the 1-nitropyrazoles to the N-unsubstituted derivatives In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Reference of 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Reference of 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of 1-methyl-5-(pyrazol-3- and -5-yl- and 1,2,4-triazol-3- and 5-yl)-1,2,3,6-tetrahydropyridine derivatives and their evaluation as muscarinic receptor ligands was written by Del Giudice, Maria Rosaria;Mustazza, Carlo;Borioni, Anna;Gatta, Franco;Tayebati, Khosrow;Amenta, Francesco;Tucci, Paolo;Pieretti, Stefano. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2003.COA of Formula: C8H7N3 This article mentions the following:

A series of 1-methyl-5-(pyrazol-3- and -5-yl- and 1,2,4-triazol-3- and 5-yl)-1,2,3,6-tetrahydropyridine derivatives structurally related to arecoline were synthesized and evaluated on M₁, M₂, and M₃ muscarinic receptors using [³H]pirenzepine and [³H]NMS as ligands. The binding affinity depended on the position and size of the substituents. The most interesting compounds were further evaluated in functional studies on isolated organs and in vivo for cholinergic side effects. Compounds 5l and 6i displayed good M₁ and M₃ antagonistic properties in vitro and were devoid of cholinergic side effects in vivo. In the experiment, the researchers used many compounds, for example, 3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9COA of Formula: C8H7N3).

3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.COA of Formula: C8H7N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

6′-Amino-5,7-dibromo-2-oxo-3′-(trifluoromethyl)-1’H-spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carbonitrile was written by Ryzhkova, Yuliya E.;Kalashnikova, Varvara M.;Elinson, Michail N.. And the article was included in Molbank in 2022.Application of 401-73-0 This article mentions the following:

In this study, the multicomponent transformation of 5,7-dibromoisatin, malononitrile, and 5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one in EtOH at reflux in the presence of sodium acetate was carefully investigated to give a novel title compound I with excellent yield. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Application of 401-73-0).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Application of 401-73-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In situ synthesis, crystal structure, selective anticancer and proapoptotic activity of complexes isolated from the system containing zerovalent nickel and pyrazole derivatives was written by Adach, Anna;Tyszka-Czochara, Malgorzata;Bukowska-Strakova, Karolina;Rejnhardt, Piotr;Daszkiewicz, Marek. And the article was included in Polyhedron in 2022.Synthetic Route of C6H9N3O This article mentions the following:

New nickel(II) complexes [NiL^S(NCS)₂]•CH₃CN (1) [Ni(dmpz)₂(NCS)₂]_n (2), where L^S is N,N,N-tris(1-(3,5-dimethylpyrazolylmethyl)amine) and dmpz is 3,5-dimethylpyrazole, were isolated in a one-pot synthesis by reacting zerovalent-powered nickel, 1-hydroxymethyl-3,5-dimethylpyrazole (HL¹) and 1-carboxamide-3,5-dimethylpyrazole (HL²) as precursors. The complexes were characterized by elemental anal., IR and UV-visible spectra, thermal studies and single crystal diffraction studies. The anti-proliferative activity of the described Ni(II) complexes was studied in vitro against selected human tumor cell lines and normal human cells (fibroblasts). The monomeric complex [NiL^S(NCS)₂]•CH₃CN (1) expressed more potent anti-proliferative activity towards cancer cells with the relevant cytotoxicity, while the polymeric complex [Ni(dmpz)₂(NCS)₂]_n (2) was very toxic towards normal cells and was also characterized by mild inhibitory potency against tumor cells and poor selectivity. 1 Causes massive death of cancer cells due to programmed cell death, apoptosis. The obtained results demonstrated potent cytotoxic activity of the isolated [NiL^S(NCS)₂]•CH₃CN complex combined with strong selectivity towards cancer cells, and the mechanism of its actions included apoptosis. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Synthetic Route of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Synthetic Route of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics