pyrazoles-derivatives

Reduction of nitro- and dinitro-1-methylpyrazoles was written by Perevalov, V. P.;Baryshnenkova, L. I.;Manaev, Yu. A.;Bezborodov, B. V.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1990.Related Products of 54210-32-1 This article mentions the following:

Reduction of 1-methyl-3-nitropyrazole by NaHS gives dimethylazoxypyrazole (I) and reduction of 1-methyl-3,5-dinitropyrazole gives a 3:1 mixture of 5-amino-1-methyl-3-nitropyrazole and dimer II. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Related Products of 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Related Products of 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and reactivity of Mannich bases. 10. N-Alkylation of pyrazoles with Mannich bases derived from ortho-hydroxyacetophenones was written by Roman, Gh.;Comanita, E.;Comanita, B.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2002.Electric Literature of C5H7ClN2 This article mentions the following:

The involvement of Mannich bases derived from ortho-hydroxyacetophenones in amine-exchange reactions with pyrazole and methyl- and/or halogen-substituted pyrazoles was studied. The corresponding β-(pyrazol-1-yl)ethyl ketones (I; R¹, R² = H, Me; R³ = H, Cl, I, NO₂) were obtained in excellent yield and were characterized by elemental anal., IR, and ¹H and ¹³C NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Electric Literature of C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Electric Literature of C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reaction of 2-aminobenzamide analogs and 2-aminothiophenol with ethyl 3-ethoxymethylene-2,4-dioxovalerate. Synthesis of pyrrolo[1,2-a]quinazoline and pyrrolo[1,2-a]benzothiazoline derivatives was written by Kurihara, Takushi;Tani, Tsutomu;Maeyama, Sigeru;Sakamoto, Yasuhiko. And the article was included in Journal of Heterocyclic Chemistry in 1980.Computed Properties of C5H8N4O This article mentions the following:

The reaction of EtOCH:C(COMe)COCO₂Et (I) with 2-H₂NC₆H₄CXNHR (X = O, R = H, Me; X = S, R = H) and 3-amino-2-methyl- or phenylpyrazole-4-carboxamides produced Et 3-aminomethylene-2,4-dioxovalerates, which led to pyrrolo[1,2-a]quinazoline-1,5-diones (II) and pyrrolo[1,2-a]pyrazolo[4,3-e]pyrimidine-1,5-dione (III) under the acidic conditions. Analogously, 2-H₂NC₆H₄SH reacted with I to give 2-HSC₆H₄NHCH:C(COMe)COCO₂Et, which was converted to pyrrolo[1,2-a]benzothiazolin-1-one under the neutral conditions. Furthermore, the heterocyclic steroidal mols. IV and V (R¹ = H, Me, Ph) were prepared by condensation of II and III with R¹NHNH₂. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7Computed Properties of C5H8N4O).

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Computed Properties of C5H8N4O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Preparations of 4-Substituted 3-Carboxypyrazoles was written by Janin, Yves L.. And the article was included in Journal of Heterocyclic Chemistry in 2013.Computed Properties of C5H7ClN2 This article mentions the following:

The scopes of three synthetic methods reported for the preparation of an array of 3-pyrazolecarboxylates featuring substituents on position 4 were studied. The first one is based on the potassium permanganate oxidation of methylpyrazoles. The second starts with the condensation between DMF dimethylacetal and Et pyruvate and is followed by the addition of hydrazine hydrochloride. The last one makes use of the cycloaddition of diazomethane on acrylate esters followed by a bromine-based oxidative rearrangement into 4-substituted 3-pyrazole esters. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Computed Properties of C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Computed Properties of C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electrochemical Nonacidic N-Nitrosation/N-Nitration of Secondary Amines through a Biradical Coupling Reaction was written by Zhao, Ji-Ping;Ding, Lu-jia;Wang, Peng-Cheng;Liu, Ying;Huang, Min-Jun;Zhou, Xin-Li;Lu, Ming. And the article was included in Advanced Synthesis & Catalysis in 2020.Quality Control of 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:

An acid-free N-nitrosation/nitration of the N-H bonds in secondary amines/azoles with Fe(NO₃)₃ · 9H₂O as the nitroso/nitro source through an electrocatalyzed radical coupling reaction was developed to give nitroso-amines I [R = piperidin-1-yl, pyrrolidin-1-yl, morpholin-4-yl, etc.] and nitro-azoles II [R¹ = 3-Me-pyrazol-1-yl, imidazol-1-yl, benzotriazol-1-yl, etc.] under mild conditions. Control and competition experiments, as well as kinetic studies demonstrated that N-nitrosation and N-nitration involved two different radical reaction pathways involving N⁺ and N^. radicals. Moreover, the electrocatalysis method enabled the preferential activation of the N-H bond over the electrode and thus provided high selectivity for specific N atoms. This strategy exhibited a broad scope and provided a green and straightforward approach to generate useful compounds I and II in good yields. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Quality Control of 3-Methyl-4-nitro-1H-pyrazole).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Quality Control of 3-Methyl-4-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Azoles. XIV. Ultraviolet study of pyrazoles was written by Elguero, Jose;Jacquier, Robert;Nguyen Tien Duc Hong Cung. And the article was included in Bulletin de la Societe Chimique de France in 1966.Synthetic Route of C6H9N3O This article mentions the following:

The uv spectra of 170 NH and N-substituted pyrazoles of general structure I were determined at 95° in EtOH. Some of the substituents were Me, CONH2, Ac, p-MeC6H4SO2, Ph, p-BrC6H4, p-O2NC6H4, 2,4-(O2N)2C6H3, and 2,4,6-(O2N)3C6H2. In the 2,4-(O2N)2C6H3 and 2,4,6-(O2N)3C6H2 series a time dependence of spectra is noted. Uv spectra are able to identify pairs of N-substituted pyrazole isomers. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Synthetic Route of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Synthetic Route of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Nitrodeiodination of polyiodopyrazoles: a convenient synthesis of 4-nitroiodopyrazoles was written by Tretyakov, Eugene V.;Vasilevsky, Sergei F.. And the article was included in Mendeleev Communications in 1995.Name: 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:

A number of 3,4-, 4,5-diiodo- and 3,4,5-triiodo-1-methypyrazoles have been converted into the corresponding almost inaccessible 3-, 5-iodo- and 3,5-diiodo-1-methyl-4-nitropyrazoles by nitration with a HNO₃-H₂SO₄ mixture In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Name: 1-Methyl-3-nitro-1H-pyrazole).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Name: 1-Methyl-3-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles. XXXIV. Ultraviolet spectra of pyrazole systems was written by Grandberg, I. I.. And the article was included in Zhurnal Obshchei Khimii in 1963.Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

Ultraviolet spectra are reported for 117 substituted pyrazoles. Halogen atoms, alkyl, or NH₂ groups produce a small bathochromic effect on the K band of pyrazole; in the presence of only these auxochromes the band is below 235 mμ; chromophores such as aryl groups, NO₂, or NO groups, caused a shift of the K band to 242-80 mμ. The largest bathochromic shift occurs with auxochromes in 1- and 4-positions. If the group interaction between these substituents and the ring occurs through p-electrons, the bathochromic shift is small. Estimation of electron mobilities of heterocyclic rings on the basis of bathochromic band shifts resulted in the following series of ascending magnitude of the shift: 2-selenophene-yl, 2-thienyl, 2-furyl, Ph. The ferrocenyl radical as a substituent on the pyrazole ring acts as a typical auxochrome and does not conjugate with the pyrazole ring. Cf. CA 58,3290f. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase was written by Staben, Steven T.;Heffron, Timothy P.;Sutherlin, Daniel P.;Bhat, Seema R.;Castanedo, Georgette M.;Chuckowree, Irina S.;Dotson, Jenna;Folkes, Adrian J.;Friedman, Lori S.;Lee, Leslie;Lesnick, John;Lewis, Cristina;Murray, Jeremy M.;Nonomiya, Jim;Olivero, Alan G.;Plise, Emile;Pang, Jodie;Prior, Wei Wei;Salphati, Laurent;Rouge, Lionel;Sampath, Deepak;Tsui, Vickie;Wan, Nan Chi;Wang, Shumei;Weismann, Christian;Wu, Ping;Zhu, Bing-Yan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Recommanded Product: 18213-75-7 This article mentions the following:

Starting from HTS hit 1a, X-ray co-crystallization and mol. modeling were used to design potent and selective inhibitors of PI3-kinase. Bioavailablity in this series was improved through careful modulation of physicochem. properties. Compound 12 (I) displayed in vivo knockdown of PI3K pharmacodynamic markers such as pAKT, pPRAS40, and pS6RP in a PC3 prostate cancer xenograft model. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7Recommanded Product: 18213-75-7).

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: 18213-75-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kinetics of hydrolysis of hypoglycemic 1-acyl-3,5-dimethylpyrazoles was written by Forist, Arlington A.;Weber, Dennis J.. And the article was included in Journal of Pharmaceutical Sciences in 1973.COA of Formula: C6H9N3O This article mentions the following:

Other investigators suggested that various 1-acyl 3,5-dimethylpyrazoles might owe their hypoglycemic activity to a nonenzymic hydrolysis in vivo to the potent compound 3,5-dimethylpyrazole. As a test of this hypothesis, relative rates of hydrolysis at pH 2.0 and 6.7 (37.6.degree.) were determined for a representative series of compounds covering a wide range of hypoglycemic potencies. No correlation between hydrolysis rates and activity was observed 3,5-Dimethylpyrazole-1-carboxamide and 3,5-dimethylpyrazole-1-N,N-dimethylcarboxamide possess equivalent biol. activity; the former was rapidly hydrolyzed (half-life about 1 hr at pH 2.0 and 6.7), whereas the latter was totally stable. Differences in biol. activity reflect intrinsic potencies of the various compounds or differences in their absorption and (or) metabolism In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5COA of Formula: C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.COA of Formula: C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics