pyrazoles-derivatives

Conventional, grinding and microwave-assisted synthesis, biological evaluation of some novel pyrazole and pyrazolone derivatives was written by Naguib, H. M.;Shaban, S. N.;Abdelghaffar, N. F.;Dauoud, N. T.;Sayed, G. H.;Anwer, K. E.. And the article was included in Journal of Basic and Environmental Sciences in 2021.Application of 51395-52-9 This article mentions the following:

Under conventional, grinding and microwave methods, reaction of 3-methyl-1H-pyrazol-5-one with benzene diazonium chloride, 4-carboxybenzenediazonium chloride and nitrous acid furnished the diazenyl derivatives resp. Reaction of 4-((3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)diazenyl)benzoic acid with salicyladehyde and 4-(chlorodiazenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one with malononitrile followed by hydrazine hydrate afforded pyrazolones resp. 3-Methyl-1H-pyrazol-5-one was converted to 4-bromopyrazolone, which when allowed to react with urea, thiourea, o-phenylenediamine, 2-amino-3-hydroxypyridine and 2-amino-5-methylphenyl furnished 4-aminopyrazolones, resp. While its reaction with p-phenylenediamine in 1:2 ratio gave bis-pyrazole derivative Also, the reaction of 3-methyl-1H-pyrazol-5-one toward thiosemicarbazide, thiourea, urea and guanidine hydrochloride gave the pyrazole derivatives, resp. The reaction of 1-(5-methyl-4H-pyrazol-3-yl)thiourea with benzaldehyde gave Schiff base, while its reaction with Et chloroacetate gave the thioxoimidazolidinone derivative, which on reaction with thiosemicarbazide afforded imidazotriazolothione derivative Also, the reactivity of pyrazole reacted with salicyladehyde and o-chlorobenzaldehyde was investigated to afford the corresponding Schiff base, resp. These new scaffolds were screened for in vitro antimicrobial and cytotoxic activities. Most analogs revealed excellent to good results. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Application of 51395-52-9).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Application of 51395-52-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Cyanoethylhydrazide in the preparation of nitrogen heterocycles. III. Heterocyclic 7-rings through the reaction of 1,3-dicarbonyl compounds with cyanoacetylhydrazide was written by Ried, W.;Kocher, E. U.. And the article was included in Angewandte Chemie in 1958.Electric Literature of C6H9N3O This article mentions the following:

Acetylacetone with cyanoacetylhydrazide in alc. in the presence of a few drops AcOH gives the mono(cyanoacetylhydrazone) (I), m. 165-6°, very soluble in dilute NaOH. The addition of at least 2 moles aqueous NaOH solution to I followed by acidification of the resulting yellow solution with AcOH yields MeC:C(CN).C(OH):N.N:CMe.CH₂ (or ketone) (II), yellow, m. 237-8°, very soluble in dilute NaOH, soluble in dilute HCl. With HNO₂, II gives orange leaves, m. 183-4°. In the same way, benzoylacetone and cyanoacetylhydrazide give PhCOCH₂CMe:NNHCOCH₂CN, (III), m. 122-3° soluble in dilute NaOH. 1-Cyanoacetyl-3-methyl-5-phenylpyrazole, m. 153-4°, may be prepared by treating III with aqueous alc. HCl. III with base yields PhC:C(CN).C(OH):N.N.CMe.CH₂ (or ketone), light yellow needles, m. 257-8° soluble in dilute NaOH and dilute HCl, gives red needles, m. 216-17°, with HNO₂. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Electric Literature of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pd-Catalyzed N-Arylation of Heteroarylamines was written by Yin, Jingjun;Zhao, Matthew M.;Huffman, Mark A.;McNamara, James M.. And the article was included in Organic Letters in 2002.Reference of 3528-58-3 This article mentions the following:

The palladium-catalyzed N-(hetero)arylation of a number of heteroarylamines including 2-aminopyridines, 2-aminothiazoles, and their analogs has been realized using Xantphos as the ligand. Weak bases such as Cs₂CO₃, Na₂CO₃, and K₃PO₄ were used in most cases to allow for the introduction of functional groups. Choice of the base and solvent was critical for the success of these reactions. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Reference of 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Reference of 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Development of a high-throughput screening analysis for 288 drugs and poisons in human blood using Orbitrap technology with gas chromatography-high resolution accurate mass spectrometry was written by Pan, Meiru;Xiang, Ping;Yu, Zhiguo;Zhao, Yunli;Yan, Hui. And the article was included in Journal of Chromatography A in 2019.SDS of cas: 73387-46-9 This article mentions the following:

The screening anal. for drugs and poisons always symbolizes the capabilities of a forensic laboratory Due to the rapid emergence of new compounds in clin. and forensic intoxication cases, sensitive and specific methods are necessary for the screening of wide range of target compounds A novel high-throughput screening method has been developed for the toxicol. anal. of 288 drugs and poisons in human blood using Orbitrap technol. with gas chromatog.-high resolution mass spectrometry (GC-HRMS). This method allows for the fast detection and identification of high-throughput forensically important drugs and poisons, e.g., drugs of abuse (cocaine, amphetamines, synthetic cannabinoids, opiates, hallucinogen), sedative-hypnotics, antidepressants, non-steroidal anti-inflammatory drugs, pesticides (acaricides, fungicides, insecticides, nematicides), and cardiovascular agents in one single GC-Q Exactive run. After a simple extraction with Et ether and buffer, following centrifugation, the supernatant was injected into the system. For detection, spiked blood samples were analyzed by Orbitrap-GC-HRMS using an electrospray ionization in full scan mode with a scan range from 40 to 650 (m/z). The identification of drugs and poisons in the samples was carried out by searching the accurate mol. mass of characteristic fragment ions, ion rations and retention time (RT) against the inhouse library that the authors developed with 70 ev electron energy. The limit of detection (LOD) for most compounds (249 in a total of 288 compounds) was below 100 ng/mL. For selectivity, no substances have been identified in drug-free blood samples from six different sources, and the method was suitable for the recovery and the carryover. The coefficient of variation (CV) of the RTs was below 0.99% in all reproducibility experiments Mass accuracy was always better than 3 ppm, corresponding to a maximum mass error of 1.04 millimass units (mmu). The developed method was applied to 136 real samples from forensic cases, demonstrating its suitability for the sensitive and fast screening of high-throughput drugs in human blood samples. In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9SDS of cas: 73387-46-9).

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.SDS of cas: 73387-46-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reactions of β-aminoenones with acetylhydrazine, semicarbazide and methoxycarbonylhydrazine. Synthesis of 1-acetyl-, 1-carboxamide- or methyl 1-carboxylated pyrazole derivatives was written by Alberola, Angel;Calvo, Luis;Ortega, Alfonso Gonzalez;Sadaba, M. Luisa;Sanudo, M. Carmen;Granda, Santiago Garcia;Rodriguez, Elena Garcia. And the article was included in Heterocycles in 1999.Product Details of 934-48-5 This article mentions the following:

Acetylhydrazine, semicarbazide and methoxycarbonylhydrazine react with β-aminoenones to give regioselectively the corresponding N-acetyl- or N-carboxypyrazole derivatives The reactions are highly regioselective and occur via 5-hydroxypyrazolines, which in several cases can be isolated and characterized. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Product Details of 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of vicinal aminoiodo- and (acetylamino)iodo-1-alkylpyrazoles was written by Tretyakov, E. V.;Vasilevsky, S. F.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1996.Safety of 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:

One-pot acylation-iodination of 3- and 5-amino-1-alkylpyrazoles gave 3- and 5-acetamido-4-iodo-1-alkylpyrazoles. Reduction of iodonitropyrazoles with SnCl₂ in HCl gave 3- and 5-iodo- and 3,5-diiodo-4-amino-1-methylpyrazole. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Safety of 1-Methyl-3-nitro-1H-pyrazole).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Safety of 1-Methyl-3-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Acidity constants of some biheterocycles was written by Tjiou, El Mostafa;Fruchier, Alain;Pellegrin, Valdo;Tarrago, Georges. And the article was included in Journal of Heterocyclic Chemistry in 1989.Category: pyrazoles-derivatives This article mentions the following:

The pKa₁ and pKa₂ of 19 biheterocycles of the form R(CH₂)_nR¹ [R, R¹ = (un)substituted imidazolyl, (un)substituted pyrazolyl, 2-pyridyl; n = 0, 1] were determined in H₂O at 25° by potentiometry and UV spectroscopy. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Category: pyrazoles-derivatives).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Weak C-H…O and C-H…N interactions in nitropyrazoles was written by Foces-Foces, C.;Jagerovic, N.;Elguero, J.. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2000.Name: 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:

The structures of 1-methyl-3-nitropyrazole and 1-methyl-4-nitropyrazole, C₄H₅N₃O₂, were determined The 3-nitro derivative has crystallog. m-symmetry while the 4-nitro compound has no imposed symmetry. The significant differences in bond distances and angles between the structures are ascribable to the electron-withdrawing effects of the nitro group attached to C3 or C4, resp. In both structures, the mols. are organized into layers by an extensive network of C-H…O or C-H…N H interactions. Within a layer, the mols. are arranged in a similar way, although differences of up to 0.3 Å in the analogous H…O or H…N intermol. distances are observed The cohesion of the layers is due to van der Waals and C-H…O contacts. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Name: 1-Methyl-3-nitro-1H-pyrazole).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Name: 1-Methyl-3-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and characterisation of palladium(II) and platinum(II) compounds containing pyrazole-derived ligands: crystal structure of [PdCl₂(HL¹)] (HL¹ = 3-phenyl-5-(2-pyridyl)pyrazole) was written by Perez, Jose Antonio;Pons, Josefina;Solans, Xavier;Font-Bardia, Merce;Ros, Josep. And the article was included in Inorganica Chimica Acta in 2005.Related Products of 19959-77-4 This article mentions the following:

Reaction of the ligands 3-phenyl-5-(2-pyridyl)pyrazole (HL¹), 3,5-bis(2-pyridyl)pyrazole (HL²), 3-methyl-5-(2-pyridyl)pyrazole (HL³) and 3-methyl-5-phenylpyrazole (HL⁴) with [MCl₂(MeCN)₂] (M = Pd(II), Pt(II)) or [PdCl₂(cod)] gives [PdCl₂(HL)₂] (HL = HL¹, HL², HL³), [Pt(L)₂] (L = L¹, L², L³) and [MCl₂(HL⁴)₂] (M = Pd(II), Pt(II)). The new complexes were characterized by elemental analyses, conductivity measurements, IR and ¹H NMR spectroscopies. The crystal and mol. structure of [PdCl₂(HL¹)] was resolved by x-ray diffraction, and consists of monomeric cis-[PdCl₂(HL¹)] mols. The Pd center has a typical square planar geometry, with a slight tetrahedral distortion. The tetracoordinated metal atom is bonded to one pyridine N, one pyrazolic N and two chloro ligands in a cis disposition. The ligand HL¹ is not completely planar. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Related Products of 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Related Products of 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Effects of hydrogen bond on the melting point of azole explosives was written by Wang, Jian-Hua;Shen, Chen;Liu, Yu-Cun;Luo, Jin;Duan, Yingjie. And the article was included in Journal of Molecular Structure in 2018.Recommanded Product: 54210-32-1 This article mentions the following:

M.p. is an important index to determine whether an explosive can be a melt cast carrier. In this study, the relationship among the mol. structure, crystal structure, and m.p. of explosives was investigated by using nitroazole compounds Hydrogen bonds influence crystal packing modes in chem. understandable ways. Hydrogen bonds also affect the changes in entropy and enthalpy in balancing melting process. Hence, different types of hydrogen bonds in explosive crystal structures were compared when the relationship between the mol. structure and the m.p. of nitroazole explosives were analyzed. The effects of Me and amino groups on intermol. hydrogen bonds were also compared. Results revealed that the Me and amino groups connected on the N(1) of the heterocyclic compound can reduce the m.p. of azole explosive. This finding is possible because Me and amino groups destroy the intermol. hydrogen bond of the heterocyclic compound In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Recommanded Product: 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Recommanded Product: 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics