pyrazoles-derivatives

Two-color delay dependent IR probing of torsional isomerization in a [AgL₁L₂]⁺ complex was written by Lang, Johannes;Gaffga, Maximilian;Menges, Fabian;Niedner-Schatteburg, Gereon. And the article was included in Physical Chemistry Chemical Physics in 2014.SDS of cas: 19959-77-4 This article mentions the following:

Two-color IR multiple photon dissociation (2c-IR-MPD) spectroscopy with delayed pulses indicates a torsional isomerization in a “ligand-metal-chelate” complex [AgL₁L₂]⁺. Ab initio calculations reveal the torsional barrier as well as the change in vibrational frequencies and IR intensities along the isomerization pathway. The current approach bears prospects for further elucidation of competing interactions within naked or microsolvated complexes in gas phase coordination chem. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4SDS of cas: 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.SDS of cas: 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Oxidative N-N coupling of N-alkyl-3-aminopyrazoles to azopyrazoles in aqueous solutions of NaOCl and NaOBr was written by Lyalin, B. V.;Sigacheva, V. L.;Ugrak, B. I.;Petrosyan, V. A.. And the article was included in Russian Chemical Bulletin in 2021.Category: pyrazoles-derivatives This article mentions the following:

The influence of the structures of N-alkyl-3-aminopyrazoles on their transformation into azopyrazoles on treatment with sodium hypohalogenites was studied. The reaction of 3-aminopyrazoles unsubstituted at position 4 containing donor substituents with neutral solutions of sodium hypohalogenites lead to mixtures of 3,3′-azopyrazoles (yields 1-40%) and 4,4′-dihalo-3,3′-azopyrazoles (yields 20-79%). In this case, generation of 3,3′-azopyrazoles was favored by the addition of NaOH to the reaction mixture The N-N coupling of aminopyrazoles with acceptor substituents in the aromatic ring resulted in the selective formation of 3,3′-azopyrazoles even in neutral media. The reactions of 4-substituted 3-aminopyrazoles with NaOBr afforded only 3,3′-azopyrazoles. The regularities of occurrence of all the above processes were discussed. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Category: pyrazoles-derivatives).

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The ultraviolet absorption spectra of pyrazoles and 1-carboxamidepyrazoles and their application was written by Shi, Yun-feng;Wu, Zhi-jie;Chen, Li-jun;Chen, Guang;Liu, Yao-peng;Zhang, Li-li. And the article was included in Guangpuxue Yu Guangpu Fenxi in 2009.Recommanded Product: 15953-73-8 This article mentions the following:

The UV absorption spectra of pyrazoles and 1-carboxamidepyrazoles were studied. The results indicated that substitution in the 3 or the 5 position it leads to a bathochromic shift of the position of the maximum absorption by about 3-4 nm, whereas in the 4 position leads to a much larger bathochromic shift (>10 nm). The introduction of carboxamide causes a bathochromic shift of the position of the maximum absorption by about 20-26 nm. Its also leads to an increase in molar extinction coefficient by about 2-3 times. So UV methods were established for determining the contents of pyrazoles and their derivations. Using these methods. the content of 3,4-dimethylpyrazole phosphate (DMPP) in stabilized urea was determined to be 1.15% of urea-N, the hydrolytic half lives of 1-carboxamide-3-methylpyrazole (CMP) in water solution at 20°, 25°, and 30° were 48, 30, and 16 h, resp., and the extraction percentage of nitrification inhibitor 3-methylpyrazole phosphate (MPP) in 3 soils by 3 different extractants were ranged from 63.2% to 89.2%. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Recommanded Product: 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Metabolic control in hypoglycemic therapy with pyrazole derivatives was written by Bacleseanu, Cornelia;Cojocaru, Zenaida;Nistor, Constantin. And the article was included in Studii si Cercetari de Biochimie in 1973.Electric Literature of C6H9N3O This article mentions the following:

The hepatic lactic acid [50-21-5] content in rats was decreased by the i.v. administration of tolbutamine [64-77-7], Maguan [Me2NC(:NH)NHC(:NH)NH2-HCl] or 3,5-dimethylpyrazole (I) [67-51-6] at 125 mg/kg, or of 4 IU insulin [9004-10-8]/kg. Maguan, and to a lesser extent tolbutamine and I decreased the hepatic pyruvic acid [127-17-3]. The liver hexokinase [9001-51-8] activity was increased markedly by tolbutamine and I, moderately by 1-carbamido-3,5-dimethylpyrazole (II) [934-48-5], and was decreased by Maguan. The aldolase [9024-52-6] activity was increased by I and was decreased by II and Maguan. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Electric Literature of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Properties and composition of the wastes of monoethanolamine treatment of hydrogen to remove carbon dioxide was written by Khitrin, S. V.;Fuks, S. L.;Devyaterikova, S. V.. And the article was included in Russian Journal of Applied Chemistry (Translation of Zhurnal Prikladnoi Khimii) in 2002.SDS of cas: 934-48-5 This article mentions the following:

The composition of the large-scale wastes from monoethanolamine treatment of pyrolysis hydrogen to remove carbon dioxide was studied. The bottoms after monoethanolamine treatment inhibit corrosion of steel with relatively poor and satisfactory protective power in acidic and neutral solutions, resp., whereas in the case of nonferrous metals they catalyze corrosion and can be used as polishing agent for copper and brass. The bottoms inhibit the atm. corrosion of steel at their content in solution of 75 mL/L. In the course of corrosion tests the content of primary and secondary amines increases. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5SDS of cas: 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.SDS of cas: 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Syntheses with silver or sodium pyrazoles. III. Reactions of sodium pyrazoles was written by Reimlinger, Hans;Noels, Alfred;Jadot, Josef;Van Overstraeten, Andre. And the article was included in Chemische Berichte in 1970.Application of 934-48-5 This article mentions the following:

Reaction of the Na salt of pyrazole with BrCN gave 2,4,6-tripyrazol-1-yl-s-triazine. Similar reaction of substituted 3,5-dimethylpyrazoles (I) (where R = Na and R1 = H or Me) gave I (where R = CN and R1 = H or Me) (II). Hydrolysis of II yielded I (R = CONH2 and R1 = H or Me) and I (R = H and R1 = H or Me). The Na salts of 4-chloro- or 4-bromopyrazole reacted with BrCN to give iminobis(4-chloropyrazol-1-yl)- or iminobis(4-bromopyrazol-1-yl)methane. Reaction of the Na salt of pyrazole with PhNCO gave 1-phenylcarbamoylpyrazole. Similar reaction of the Na salts of pyrazole or I with CHCCH2Br gave 35-76% trisubstituted 1-propargylpyrazoles (III) (R, R1, R2 = H or Me). In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Application of 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Application of 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Optimization of synthesis of nitroimidazoles and nitropyrazoles based on polarographic investigations was written by Dumanovic, D.;Kosanovic, Dj.;Zuman, P.. And the article was included in Heterocycles in 1994.Safety of 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:

A direct, simple, fast, and inexpensive polarog. method enables selective determinations of nitroimidazoles or nitropyrazoles in mixtures, which can be used for monitoring synthetic processes and selecting optimal conditions for synthesis. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Safety of 1-Methyl-3-nitro-1H-pyrazole).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Safety of 1-Methyl-3-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Direction of ring opening of some unsymmetrical ethylene oxides and sulfides was written by Davies, W.;Savige, W. E.. And the article was included in Journal of the Chemical Society in 1951.Safety of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

ClCH₂CHClCH₂SH (I), b₂₀ 74-6°, n¹⁵_D 1.5245, heated 2 h. on the water bath with excess AcCl, gives ClCH₂CHClCHSAc (II), b₂₅ 122°, n²⁰_D 1.5155; ClCH₂CH.CH₂.S (III) and AcCl, heated 5 h. at 50-5°, also give II. Hydrolysis of II gives a good yield of I. I does not react with 2,4-(O₂N)₂C₆H₃Cl (IV), 2,4-(O₂N)₂C₆H₃F, or picryl chloride, the alk. reagents used (NaOH, NaHCO₃, and AcONa) convert I into III. I and PhNCO in petr. ether (3 h. at 160°) give the thiolcarbanilate, m. 100°; heated with aqueous NaOH, it yields III. I and Ph₃CCl in petr. ether (4 h. at 100°) give 2,3-dichloropropyl triphenylmethyl sulfide, m. 128°. II (12.5 g.), 15 g. NaI, and 10 g. Mg in 25 cc. MeCOEt, refluxed 24 h., give about 3 mL. of a product b. 100-40°, which with IV in aqueous alc. NaOH yields 0.4 g. allyl 2,4-dinitrophenyl sulfide, yellow, m. 71°; this results also from CH₂:CHCH₂Br and 2,4-(O₂N)₂C₆H₃SH (V) in alc. NaOH. ClCH₂CH(OH)CH₂SH, IV, and NaOH (equimol. quantities in EtOH) give 1-(2,4-dinitrophenylmercapto)-3-chloro-2-propanol (VI), yellow, m. 81-2°; this results also from V and ClCH₂CH.CH₂.O in saturated aqueous NaHCO₃. VI in ether-C₆H₆, stirred 1 h. with excess cold 40% aqueous NaOH, gives 2,3-epoxypropyl 2,4-dinitrophenyl sulfide (VII), yellow, m. 94-5°. VII, refluxed 4 h. with aqueous AcOH, gives 60% 1-(2,4-dinitrophenylmercapto)-2,3-propanediol, yellow, m. 142-3°; this results also from HOCH₂CH.CH₂.O and V with aqueous Na₂CO₃ and NaHCO₃. Me₂C.CH₂.S (7.1 g.), 9 g. Ac₂O, and 0.6 mL. C₅H₅N, heated 1 h. on the water bath and 15 h. at 130°, give 9 g. 2-acetylmercapto-2-methylpropyl acetate (VIII), b₁₅ 114°. Hydrolysis (6 h.) of VIII with 1% MeOH-HCl gives 2-mercapto-2-methyl-1-propanol (IX), b₃₀ 70°, n²²_D 1.469; HNO₂ gives a green flash which soon changes to a light red color. IX and IV with NaOH in EtOH give 2-(2,4-dinitrophenylmercapto)-2-methyl-1-propanol, yellow, m. 108.5°. Me₂C.CH₂.O (IXA) (7.2 g.) and 7.6 g. AcSH, warmed 7 h. on the water bath, give a mixture of HOCMe₂CH₂SAc and AcOCMe₂CH₂SH, b₁₂ 80-100°; hydrolysis gives 80% 2-hydroxy-2-methyl-1-propanethiol (X), b₁₇ 73-4°. X, IV, and NaOH in EtOH yield 1-(2,4-dinitrophenylmercapto)-2-methyl-2-propanol (XI), yellow, m. 95.5°. HOCMe₂CH₂Cl or IXA and V with NaOH in EtOH also give XI. XI and SOCl₂, warmed 0.5 h. on the water bath, give Me₂CClCH₂SC₆H₃(NO₂)₂-2,4, yellow, m. 86-7°. MeCH.CH₂.O and V with aqueous NaHCO₃ yield MeCH(OH)CH₂SC₆H₃(NO₂)₂-2,4 which with PCl₅ in CHCl₃ gives MeCHClCH₂SC₆H₃(NO₂)₂-2,4, m. 75-7°. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Safety of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Safety of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Nitrogen systems. VII. The kinetics of ethanolysis of 1-acylpyrazoles was written by Scott, F. L.. And the article was included in Chimia in 1957.Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:

The ethanolysis rate constants of a number of 1-acylpyrazoles, determined spectrophotometrically, are tabulated, and the possible reaction mechanisms are discussed on the basis of these figures. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adamantylazoles. IV. Acid-catalyzed adamantylation of pyrazoles was written by Gavrilov, A. S.;Golod, E. L.;Kachala, V. V.;Ugrak, B. I.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 2001.Reference of 5334-39-4 This article mentions the following:

Pyrazoles with pK_BH⁺ no more than 0.8 and having substituents in the 3(5) position with effective van der Waals radii not exceeding 2 Å in a mixture of phosphoric and acetic acids at weight ratio 4:1 (H₀ -1.8) react with 1-adamantanol to afford 1-(1-adamantyl)- or 1,4-di-1-adamantylpyrazoles. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Reference of 5334-39-4).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Reference of 5334-39-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics