pyrazoles-derivatives

Studies on some new bridgehead nitrogen heterocyclic cyanine dyes was written by Koraiem, A. I. M.;Shindy, H. A.;Abu El-Hamd, R. M.. And the article was included in Proceedings – Indian Academy of Sciences, Chemical Sciences in 1999.Safety of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one This article mentions the following:

New asym. mono-(tri)-methine and azomethine cyanine dyes of pyrazolo[5,4-b]quinolino[a,b]-1,4-pyra-(oxa)-zinium bromide salts were prepared The newly synthesized cyanines were identified by elemental and spectral analyses. The visible absorption spectra of some selected dyes were investigated in single and mixed solvents, and also in aqueous buffer solutions The spectral shifts were studied in relation to mol. structure and in terms of medium effects. Mol. complex formation with DMF was verified through mixed-solvent studies. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Safety of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Safety of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and Anticancer Activity of 9-O-Pyrazole Alkyl Substituted Berberine Derivatives was written by Xiao, Daipeng;He, Fen;Peng, Dongming;Zou, Min;Peng, Junying;Liu, Pan;Liu, Yanfei;Liu, Zhenbao. And the article was included in Anti-Cancer Agents in Medicinal Chemistry in 2018.Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

Objective: In this study, seven BBR derivatives were synthesized and their anticancer activity against HeLa cervical and A549 human lung cancer cell lines were evaluated in vitro. Methods: The anti-cancer activity was measured by MTT assay, and apoptosis was demonstrated by the annexin V-FITC/PI staining assay. The intracellular oxidative stress was investigated through DCFH-DA assay. The mol. docking study was carried out in mol. operating environment (MOE). Results: Compound B3 and B5 showed enhanced anti-cancer activity compared with BBR, the IC50 for compound B3 and B5 were significantly lower than BBR, and compound B3 at the concentration of 64 or 128 induced apoptosis in HeLa and A549 cell lines. The reactive oxygen species (ROS) was generated in both cell lines when treated with 100 of all the compounds, and compound B3 and B5 induced higher activity in the generation of ROS, while compound B3 exhibited the highest activity, these results are in accordance with the cytotoxicity results, indicating the cytotoxicity were mostly generated from the oxidative stress. In addition, mol. docking anal. showed that compound B3 had the greatest affinity with Hsp90. Upon binding, the protective function of Hsp90 was lost, which might explain its higher cytotoxicity from mol. interaction aspect. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles. XXI. Biological activity of pyrazole derivatives was written by Grandberg, I. I.;Milovanova, S. N.;Kost, A. N.;Nette, I. T.. And the article was included in Vestnik Moskovskogo Universiteta, Seriya 6: Biologiya, Pochvovedenie in 1961.Electric Literature of C4H5N3O2 This article mentions the following:

Ninety-six pyrazole (I) derivatives were tested by the paperdisk method for their effect on the growth of various bacterial cultures. A majority of the compounds tested were in effective; only those derivatives containing Hg were effective. 3,5-Dimethyl-4-nitropyrazole, m. 126°; 3,5-dimethyl-4aminopyrazole, m. 204-5°; 4-nitro-3-methylpyrazole, m. 134°; 4-amino-3(5)-methylpyrazole, m. 90°; 3,5-dimethyl4-thiocyanatopyrazole, m. 209°; 3,5-dimethylpyrazole-4sulfonyl chloride, m. 98°; 3,5-dimethyl-4-chloropyrazole, m. 117°; 3,5-dimethyl-4-chloro-1-pyrazolylsuccinic acid, m. 191°; and 3,5-dimethyl-4-nitro-1-pyrazolylsuccinic acid, m. 189° were prepared In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Electric Literature of C4H5N3O2).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Electric Literature of C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Metal-catalyzed oxidations. Part 6. Molybdenum-catalyzed olefin epoxidation: ligand effects was written by Thiel, Werner R.;Eppinger, Joerg. And the article was included in Chemistry – A European Journal in 1997.Name: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

0E synthesized substituted pyrazolylpyridine ligands to examine their donor properties by spectroscopic (IR, NMR) and computational (AM1) methods. The influence of the substitution patterns on spectroscopic and thermodn. features of molybdenum oxobisperoxo complexes [(L-L)MoO(O₂)₂] [L-L = 2-(1-alkyl-3-pyrazolyl)pyridine/pyrazine] correlates with the activities of the complexes in catalytic olefin epoxidation reactions. This further proof for the relation between the Lewis acidity and the catalytic activity of epoxidation catalysts supports a reaction mechanism in which the peroxo complex activates the oxidizing agent (H₂O₂, ROOH) instead of directly transferring an oxygen atom from a η²-peroxo ligand to the olefin. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Name: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Name: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Structure of the products of acrolein reactions with pyrazoles was written by Attaryan, O. S.;Antanosyan, S. K.;Kinoyan, F. S.;Tamazyan, R. A.;Panosyan, G. A.;Matsoyan, S. G.. And the article was included in Russian Journal of Organic Chemistry in 2006.Application of 15953-73-8 This article mentions the following:

Pyrazoles reacted with acrolein to give p1-pyrazolepropanals in fairly high yields. 3,5-Dimethyl-1-pyrazolepropanal dimerized on standing to the oxygen-linked dimer which on treatment with H₂NOH gave 3,5-dimethyl-1-pyrazolepropanal oxime. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Application of 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application of 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Coordination tendencies of acidic amino groups. VIII. Complexing behavior of 3-methyl-5-pyridyl-2-pyrazole was written by Hennig, Horst;Daute, Ingeborg. And the article was included in Zeitschrift fuer Chemie in 1971.Application of 19959-77-4 This article mentions the following:

3-Methyl-5-(2-pyridyl)pyrazole (HMPP) reacted with metal acetylacetonates to give the following complexes: [Cu(MPP)2], [Ni(MPP)2], [Co(MPP)3], [Zn(MPP)2], [Pd(MPP)2], (Cu(HMPP)Cl2] and [Co(HMPP)Cl2]. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Application of 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application of 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Facile and environmentally friendly synthesis of nitropyrazoles using montmorillonite K-10 impregnated with bismuth nitrate was written by Ravi, P.;Tewari, Surya P.. And the article was included in Catalysis Communications in 2012.Product Details of 54210-32-1 This article mentions the following:

Nitropyrazoles in higher yields were synthesized using montmorillonite K-10 impregnated with bismuth nitrate and the present procedure may be applied for the nitration of a wide variety of azoles in the drug and pharmaceutical industries. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Product Details of 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Product Details of 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Amination of isomeric bromo-1-methylnitropyrazoles was written by Perevalov, V. P.;Baryshnenkova, L. I.;Andreeva, M. A.;Manaev, Yu. A.;Denisova, I. A.;Stepanov, B. I.;Seraya, V. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1983.Related Products of 54210-32-1 This article mentions the following:

Bromination of 1-methylpyrazole by Br-AcOH gave 53% of a mixture of 4,5-dibromo- and 3,4-dibromo-1-methylpyrazoles, which was nitrated to give 5-bromo-4-nitropyrazole (I) and 3-bromo-4-nitropyrazole. Amination of I by aqueous NH₃ gave 5-amino-4-nitro-1-methylpyrazole. Amination of 4-bromo-5-nitro-1-methylpyrazole gave 4-amino-5-nitro-1-methylpyrazole; amination of 4-bromo-3-nitro-1-methylpyrazole gave 4-amino-3-nitro- and 3-nitro-1-methylpyrazoles. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Related Products of 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Related Products of 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Azoles. XIII. Nuclear magnetic resonance spectra of pyrazoles was written by Elguero, Jose;Jacquier, Robert;Nguyen Tien Duc Hong Cung. And the article was included in Bulletin de la Societe Chimique de France in 1966.Quality Control of 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:

The N.M.R. spectra of 180 pyrazoles in nonaqueous solvents (CDCl3, CCl4, C6H6, Me2SO, CF3CO2H) were analyzed. Classes represented were non-N-substituted, N-alkyl (especially N-Me), N-carboxamide, N-tosyl, N-Ph, N-p-nitrophenyl, N-(2,4-dinitrophenyl), and 2,4,6-trinitrophenyl pyrazoles. Chem. displacements (τ) and coupling constants (J) were calculated and compared with literature values. Differences in values were attributed to substituents in ring positions 3, 4, and 5. Steric hindrance between the pyrazolic nucleus and aromatic substituents and the effect of C-Me groups on shielding of the pyrazolic protons was studied. 85 references. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Quality Control of 3-Methyl-4-nitro-1H-pyrazole).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Quality Control of 3-Methyl-4-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The middle ultraviolet absorption of some pyrazoles derived from β-dicarbonyl compounds was written by Dayton, Peter G.. And the article was included in Compt. rend. in 1953.Product Details of 934-48-5 This article mentions the following:

The bathochromic effect of substituents on the absorption of pyrazole increases as follows: pyrazole < alkylpyrazole < pyrazolecarboxylic acid < phenylpyrazole < phenylpyrazolecarboxylic acid. Absorption spectrum curves between 3000-2142 A. are given for pyrazole and its following derivatives (substituents given): 3(5)-Me (I); 1,3,5-tri-Me; 1-Ph, 3(5)-tert-Bu, m. 75-6°, b₇₆₀ 268°, b₁₈ 152°; 1-Ph,3(5)-Me, 5(3)-tert-Bu, m. 85°, b₇₅₈ 272°, b₁₄ 153°; 1-Ph, 3,5-di-Me (II); 3(5)-Ph; 3,5-di-Me, 1-H₂NCO (III); 3,5-di-Me, 4-EtO₂C; 3(5)-HO₂C; 1-Ph, 3,5-di-Me, 4-EtO₂C; 3(5)-Ph, 5(3)-EtO₂C. The 3,5-di-Me, 3(5)-tert-Bu, m. 53-5°, b₇₆₀ 214°, b₁₅ 115°, and 3(5)-Me, 5(3)-tert-Bu, m. 169-71°, b₇₆₀ 225°, derivatives all show the same absorption as I; the 1-Ph, 3,4,5-tri-Me derivative the same as II, and the 5(3)-tert-Bu, 1-H₂NCO, m. 93°, and 3(5)-Me, 5(3)-tert-Bu, 1-H₂NCO, m. 113-14°, the same as III. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Product Details of 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Product Details of 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics