pyrazoles-derivatives

Extraction and analysis on the aromatic components of Pu-erh ripe tea and raw tea was written by Hong, Tao;Huang, Zun-xi;Li, Jun-jun;Tang, Xiang-hua;Mu, Yue-lin;Xu, Bo. And the article was included in Chaye Kexue in 2010.Name: 1-Ethyl-1H-pyrazol-5-amine This article mentions the following:

The aromatic components from Pu-erh ripe and raw tea which storage for different years extracted by methylene chloride and Et ether through vacuum distillation extraction, and then investigated by gas chromatog.-mass spectrometry. It showed that the aromatic compounds extracted by methylene chloride were more than Et ether no matter they were ripe tea or raw tea. Those compounds including hydrocarbons, heterocyclic oxygen compounds, nitrogenous compounds, ketones were extracted more by methylene chloride than those extracted by Et ether. However, more esters and phenolic compounds were extracted by Et ether. The contents of benzothiazole and caffeine increased during the process of ripe tea’s storage, but the contents of phthalic acid, iso-Bu octyl ester and 1,2,4-trimethoxybenzene were decreased. The contents of 5-amino-1-ethylpyrazole, N-phenyl-1-naphthalenamine, 1,2,3-trimethoxybenzene and phthalic acid-iso-butyl-octyl ester were increased during the storing process of raw tea, but the contents of trans-squalene, linalool, beta-iso-Me ionone and caffeine were decreased. At the same time, there were many aromatic compounds of heterocyclic oxygen compounds in ripe tea. The main components of these 10 heterocyclic oxygen compounds included 1,2,3-trimethoxybenzene. The contents of alcs. aromatic components in raw tea, such as 1-octen-3-yl, linalool, cyclohexanol, 2,6-dimethylcyclohexanol, Ph Et alc. and cedrol. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Name: 1-Ethyl-1H-pyrazol-5-amine).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Name: 1-Ethyl-1H-pyrazol-5-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Unambiguous synthesis of 4,7-dihydro-4-oxo-1H-pyrazolo[3,4-b]pyridine – further comments on the “(N-C) rearrangement” of [2-(alkoxycarbonyl)vinylamino]pyrazoles was written by Dorn, Helmut;Ozegowski, Ruediger. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1982.Recommanded Product: 3528-58-3 This article mentions the following:

Successive decarboxylation of pyrazolopyridine I and debenzylation of II (R¹ = CH₂Ph, R² = H) with Na in NH₃(l) gave the title compound II (R¹ = R² = H). The product from 3-aminopyrazole and HCCCO₂Me, formerly described as II (R¹ = R² = H), is the 6-oxo isomer III (R¹ = R² = H). Debenzylation of II (R¹ = CH₂Ph, R² = H) and analogs with SeO₂ is only possible if the position α to the C:O is blocked; otherwise, selenides of type IV are formed. Cyclizing pyrazoles V (R¹ = R² = H, R¹ = CH₂Ph, R² = H, Me; R³ = Me, Et) in acidic media with catalytic amounts the corresponding aminopyrazoles gave pyrazolopyridines III via pyrazoles VI, i.e., via products of a N-C rearrangement, whereas thermal cyclization of V gave II (R¹,R² as above and also R¹ = CH₂Ph, R² = Me). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Recommanded Product: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Selective palladium-catalyzed direct C-H arylation of unsubstituted N-protected pyrazoles was written by Kumpulainen, Esa T. T.;Pohjakallio, Antti. And the article was included in Advanced Synthesis & Catalysis in 2014.Recommanded Product: 3-(1H-Pyrazol-3-yl)pyridine This article mentions the following:

A highly selective C-5 arylation of N-dimethylaminosulfamoyl-protected pyrazole with aryl bromides is catalyzed by 2-5 mol% palladium in the presence of triphenylphosphine ligand and carboxylic acid additive. Selectivities up to 45:1 (C-5:C-4) can be achieved by running the reaction in non-polar solvents. A thorough study of scope and limitations shows good general tolerance of aryl bromide substitution. However, limitations on tolerance of ortho-substitution and protic functional groups were established. Together with a telescoped deprotection step this method presents a viable alternative for the synthesis of C-3 arylated pyrazole building blocks. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. In the experiment, the researchers used many compounds, for example, 3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9Recommanded Product: 3-(1H-Pyrazol-3-yl)pyridine).

3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Recommanded Product: 3-(1H-Pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Solvatochromism of heteroaromatic compounds: XXVIII. Factors affecting the nonspecific solvatochromic effect in the UV spectra of aromatic nitro compounds in aprotic protophilic solvents was written by Vokin, A. I.;Shulunova, A. M.;Aksamentova, T. N.;Bozhenkov, G. V.;Turchaninov, V. K.. And the article was included in Russian Journal of General Chemistry in 2006.Related Products of 54210-32-1 This article mentions the following:

Examination of the UV spectra of a large series of solvatochromic indicators of the general formula 1-X-4-NO₂-C₆H₄ in aprotic solvents confirmed the proportionality between the dipole moments of these compounds in the ground (μ_g) and first electronically excited (¹A₁, μ_e) states: μ_e = r_μμ_g. The coefficient r_μ was determined by applying the equation of the Bakhshiev-Bilot-Kawski solvatochromism theory both to nonspecifically solvated mols. and to their H complexes with aprotic protophilic solvents. An anisotropy of the electron redistribution was revealed for low-symmetry 1-substituted 2,4-dinitrobenzenes. The r_μ value obtained allowed the calculation of the Kamlet-Taft empirical solvatochromic parameter π* on the basis of generalized characteristics of the solvent. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Related Products of 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Related Products of 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Azoles. XIII. Nuclear magnetic resonance spectra of pyrazoles was written by Elguero, Jose;Jacquier, Robert;Nguyen Tien Duc Hong Cung. And the article was included in Bulletin de la Societe Chimique de France in 1966.Electric Literature of C5H7ClN2 This article mentions the following:

The N.M.R. spectra of 180 pyrazoles in nonaqueous solvents (CDCl3, CCl4, C6H6, Me2SO, CF3CO2H) were analyzed. Classes represented were non-N-substituted, N-alkyl (especially N-Me), N-carboxamide, N-tosyl, N-Ph, N-p-nitrophenyl, N-(2,4-dinitrophenyl), and 2,4,6-trinitrophenyl pyrazoles. Chem. displacements (τ) and coupling constants (J) were calculated and compared with literature values. Differences in values were attributed to substituents in ring positions 3, 4, and 5. Steric hindrance between the pyrazolic nucleus and aromatic substituents and the effect of C-Me groups on shielding of the pyrazolic protons was studied. 85 references. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Electric Literature of C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Electric Literature of C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of heterocyclic systems with a carbohydrate fragment. 1. Stereoselective synthesis of azolo anhydro sugars by addition of azoles to levoglucosenone was written by Samet, A. V.;Laichter, A. L.;Reznikov, D. N.;Yamskov, A. N.;Ugrak, B. I.;Chernyshova, N. B.;Yolkin, V. V.;Semenov, V. V.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1994.Recommanded Product: 5334-39-4 This article mentions the following:

Levoglucosenone (I) reacts with NH-azoles in the presence of bases to give Michael adducts, e.g., II (Az = 3-nitropyrazol-1-yl, 5-nitrotetrazol-2-yl), and in some cases their hydrates (gem-diols) also. In all cases the addition proceeds stereospecifically and with good yields. 3-Nitro-s-triazole, 3- and 4-nitropyrazole, 3-methyl-4-nitropyrazole, 5-nitrotetrazole, 4,5-dicarbomethoxy-v-triazole, 3,4-dinitropyrazole, 3(5)-methylpyrazole, pyrazole and imidazole are used in this reaction. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Recommanded Product: 5334-39-4).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Recommanded Product: 5334-39-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics