pyrazoles-derivatives

Diene synthesis in the pyrazole series. Preparation of 6-anilinopyridines was written by Abjean, Francois. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1974.Electric Literature of C6H9N3O This article mentions the following:

The anilinopyridinium tetrafluoroborates I (R = Ph, p-O2NC6H4), p-ClC6H4) were formed by treating BF3 complexes of the pyrazoles II with MeO2CCCCO2Me. Treatment of I with KOH gave the pyridineamines III. The pyrazoles II (R = Ac, Bz, CONH2) also formed BF3 complexes which did not undergo diene synthesis, giving instead II (R = H). In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Electric Literature of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Mass spectrometry of nitroazoles. I. The mass spectra of methyl substituted nitropyrazoles was written by Luijten, W. C. M. M.;Van Thuijl, J.. And the article was included in Organic Mass Spectrometry in 1979.COA of Formula: C4H5N3O2 This article mentions the following:

The mass spectra of all isomers of methylnitropyrazoles are reported. Generally, the spectra are characteristic of nitropyrazoles. In some cases however, ortho effects occur, which were recognizable by the primary loss of •OH, H₂O, •CHO and HCHO. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4COA of Formula: C4H5N3O2).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.COA of Formula: C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Five new mononuclear complexes of 2-(5-methyl-1H-pyrazol-3-yl)pyridine: Synthesis, crystalline architectures through supramolecular interactions and spectroscopy was written by Zhu, Guang-Zhou;Xing, Bei-Bei;Yang, Feng-Lei;Li, Xiu-Ling. And the article was included in Polyhedron in 2014.Recommanded Product: 19959-77-4 This article mentions the following:

Five new mononuclear complexes with 2-(5-methyl-1H-pyrazol-3-yl)pyridine (L) were synthesized, namely [ZnLCl₂] (1), [NiL₂(H₂O)₂]Cl₂·0.5N₂H₄ (2), [MnL₂Cl₂]·3H₂O (3), [CdL₂(NO₃)₂] (4) and [MnL₂(Pa)₂] (5, Pa = m-phthalic acid). All these compounds were characterized by elemental anal., IR and UV-visible spectroscopy, and x-ray single crystal diffraction. The crystal structures reveal that compounds 2, 3 and 5 afford six-coordinated octahedral spheres, while compound 1 displays a four-coordinated tetrahedral core and compound 4 forms an eight-coordinated geometry. Furthermore, the 3D supramol. networks, formed through plentiful H-bonds and weak mol. interactions, were analyzed. The photoluminescent properties of the ligand L, together with compounds 1 and 4, were also studied in methanol solution at room temperature In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Recommanded Product: 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

N-Amination of pyrazoles: a general approach was written by Vinogradov, Vasilii M.;Dalinger, Igor L.;Shevelev, Svyatoslav A.. And the article was included in Mendeleev Communications in 1993.Recommanded Product: 5334-39-4 This article mentions the following:

A general approach to N-amination of pyrazoles, allowing the synthesis of previously inaccessible N-aminopyrazoles with electron-acceptor substituents in the ring, has been proposed, consisting of treatment of the pyrazoles with hydroxylamine-O-sulfonic acid in aqueous media at controlled pH depending on the pK_a of the pyrazole. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Recommanded Product: 5334-39-4).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 5334-39-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Determination of volatile flavor compounds in raw and treated duck meats of different body parts was written by Zhen, Zong-Yuan;Liu, Yi-Lin;Wang, Jie;Li, Jing-Jun;Li, Xian-Bao;Zheng, Hai-Bo. And the article was included in Journal of Food Biochemistry in 2022.Product Details of 934-48-5 This article mentions the following:

The compounds in volatile flavor substances in duck meats of three different body parts (breast, leg, and wing) were extracted by headspace solid-phase micro-extraction and determined by gas chromatog.-mass spectrometry. A total of 16 main volatile compounds including 4 hydrocarbons, 4 alcs., 2 acids, 3 aldehydes, and 3 others (N-containing, S-containing) were identified in raw duck meats from three different body parts. The hydrocarbon compounds account for more than 50% of all volatile substances in all three body parts. And the percentage of hydrocarbon compounds in raw duck breast meat reaches 82.76%. A total of 81 volatile compounds including 15 hydrocarbons, 10 alcs., 7 acids, 12 aldehydes, 4 esters, 19 S-containing and N-containing compounds, and 14 others were isolated and identified in 1 h-marinated and cooked duck meats. A total of 101 kinds of volatile flavor compounds including 13 hydrocarbons, 14 alc., 7 acids, 8 aldehydes, 12 esters, 23 S-containing and N-containing compounds, and 24 others were detected in 3 h-marinated duck meats of the three body parts. It was proved in this study that under the same conditions, the volatile compounds in duck legs are more than those in duck breasts and wings, and the types of volatile flavor substances increase significantly in duck meats after cooked. Practical applications Prepared and cooked duck meat, especially wings and legs are popular food in China. The results suggest that Pickling makes duck meat more flavory while proper pickling time is less than 3 h. Duck wings are better for marinating and cooking compared with duck breasts and legs. The acceptance study of duck meat from different body parts and the anal. of volatile flavor compounds are beneficial for optimizing utilization of whole parts of duck meat. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Product Details of 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Product Details of 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Deprotonation of metal complexes derived from ligands containing pyrrole, pyrazole, and indene residues was written by Chiswell, B.. And the article was included in Inorganica Chimica Acta in 1972.Formula: C9H9N3 This article mentions the following:

The synthesis of several new planar nitrogenous tridentate ligands, specially designed to present their donor atoms at positions very close to the normal octahedral sites of a metal atom, are described. Each of these ligand moieties, when complexed to a metal atom, also possess the potential ability to lose a proton from the periphery of the ligand mol. to yield deprotonated non-charged metal complexes. The lack of change in color and magnetic moment of complexes of these ligands, upon undergoing such deprotonation reactions, is compared with the marked increase in color intensity and decrease in magnetic moment when charged complexes containing a 2-pyridylhydrazine entity in the ligand residue undergo similar deprotonation reactions. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Formula: C9H9N3).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Formula: C9H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazole carboxamides and carboxylic acids as protein kinase inhibitors in aberrant eukaryotic signal transduction: Induction of growth arrest in MCF-7 cancer cells was written by Persson, Tobias;Yde, Christina W.;Rasmussen, Jakob E.;Rasmussen, Tine L.;Guerra, Barbara;Issinger, Olaf-Georg;Nielsen, John. And the article was included in Organic & Biomolecular Chemistry in 2007.HPLC of Formula: 10199-53-8 This article mentions the following:

Densely functionalized pyrazolecarboxamides, e.g. I, and pyrazolecarboxylic acids were prepared through saponification and transamidation of ester-functionalized pyrazoles. This synthetic protocol allowed for three diversifying steps in which appendages on the pyrazole scaffold were adjusted to optimize inhibition of protein kinases. Thirty-five analogs were tested in CK2, AKT1, PKA, PKCα, and SAPK2a (p38) kinase inhibition bioassays. Blocking of these kinases may lead to effective therapies for treating inflammatory diseases and cancer. In order to investigate potential biol. activity, MCF-7 human breast cancer cells were incubated with the most promising derivatives Two analogs caused changes in MCF-7 cell growth, one of them through cell cycle arrest demonstrated by cell cycle anal. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8HPLC of Formula: 10199-53-8).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.HPLC of Formula: 10199-53-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Development and a Practical Synthesis of the JAK2 Inhibitor LY2784544 was written by Mitchell, David;Cole, Kevin P.;Pollock, Patrick M.;Coppert, David M.;Burkholder, Timothy P.;Clayton, Joshua R.. And the article was included in Organic Process Research & Development in 2012.Reference of 141459-53-2 This article mentions the following:

The route selection and process research and development of a practical synthesis for JAK2 inhibitor LY2784544 is described. The first-generation synthesis route, similar to that used in discovery for derivatization of a benzylic amine moiety, was 14 overall steps and possessed several steps that required extensive development for large-scale production Route selection considerations led to a modified synthesis that utilized a novel vanadium-catalyzed carbon-carbon bond-forming arylation reaction for incorporation of the key benzylic morpholine moiety. A protecting group used to mask an amino pyrazole unit was modified from PMB to tert-Bu, resulting in a dramatic reduction in the overall length of the route. These two major changes resulted in an eight-step synthesis, which was six steps shorter than the first-generation synthesis. In the pilot plant, the new synthesis was scaled to produce >100 kg of LY2784544 in high yield and purity under GMP conditions. The overall development including the vanadium-catalyzed C-C bond-forming methodol., a ketone reductive deoxygenation, and a palladium-catalyzed amination is described. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2Reference of 141459-53-2).

1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Reference of 141459-53-2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

gem-Dinitro compounds in organic synthesis. 2. Synthesis of 4-nitropyrazoles from dinitromethane and its derivatives was written by Laikhter, A. L.;Cherkasova, T. I.;Semenov, V. V.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1991.SDS of cas: 5334-39-4 This article mentions the following:

Treating azines RCH:NN:CHR (R = Me, Pr) with the Na salt of CH₂(NO₂)₂ in MeCN gave 27 and 21% nitropyrazoles I. Treating RCH:NN:CHC(NO₂)₂^– K⁺ in MeCN containing AcOH gave 17 and 18% nitropyrazoles II [R = Me, C(NO₂)₂], which underwent fluorination and chlorination to give 65 and 81% II [R = C(NO₂)₂F, C(NO₂)₂Cl]. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4SDS of cas: 5334-39-4).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.SDS of cas: 5334-39-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A highly efficient photochemical bromination as a new method for preparation of mono, bis and fused pyrazole derivatives was written by Ahmed, Saleh A.;Awad, Ibrahim M. A.;Abdel-Wahab, Aboel-Magd A.. And the article was included in Photochemical & Photobiological Sciences in 2002.Recommanded Product: 51395-52-9 This article mentions the following:

N-Bromosuccinimide (NBS) was found to afford photochem. bromination of N-substituted 3-methyl-2-pyrazolin-5-ones in chloroform solution The nature of the products formed was found to be highly dependent on the photolysis time and on the type of N-substituted 3-methyl-2-pyrazolin-5-one. The reaction of substituted 2-pyrazolin-5-ones with NBS in the absence of light yielded in all cases a mixture of N-substituted 3-methyl-4-bromo- (and -4,4-dibromo-) 2-pyrazolin-5-ones. The mechanism of photobromination was illustrated. Separation of all of the products was achieved using column chromatog. The chem. structure of all of the products was assigned by elemental anal., IR, ¹H NMR and GC-MS measurements. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Recommanded Product: 51395-52-9).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Recommanded Product: 51395-52-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics