Reference of (3-methyl-1H-pyrazol-5-yl)methanolOn September 15, 2009 ,《Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Heim-Riether, Alexander; Taylor, Steven J.; Liang, Shuang; Gao, Donghong Amy; Xiong, Zhaoming; Michael August, E.; Collins, Brandon K.; Farmer, Bennett T.; Haverty, Kathleen; Hill-Drzewi, Melissa; Junker, Hans-Dieter; Mariana Margarit, S.; Moss, Neil; Neumann, Thomas; Proudfoot, John R.; Keenan, Lana Smith; Sekul, Renate; Zhang, Qiang; Li, Jun; Farrow, Neil A.. The article contains the following contents:
Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was observed to have a binding mode distinct from previously published MMP-13 inhibitors. Potency and selectivity were improved by extending the hit structure out from the active site into the S1′ pocket. In the experiment, the researchers used many compounds, for example, (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Reference of (3-methyl-1H-pyrazol-5-yl)methanol)
(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Reference of (3-methyl-1H-pyrazol-5-yl)methanol
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics