330792-70-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 330792-70-6 name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a dry 10 L three-necked flask was added Compound 1a (600 g, 2.17 mol)Compound 2a (815 g, 2.39 mol),Powdered cesium carbonate (1417 g, 4.35 mol) and N, N-methylformamide (DMF, 6 L) were added,Mechanical stirring, heating the internal temperature rose to 80 (about 1.5 hours)After 2 hours to send HPLC monitoring reaction, the reaction is complete, stop heating, cooled to room temperature,Then add 10L ethyl acetate and 15L water, stirred for 30 minutes (speed 200), allowed to stand,Liquid separation, the water phase to discard, the organic phase with 1kg anhydrous sodium sulfate and stir, filtered,The filtrate was concentrated dark reddish brown oil, the crude product was recrystallized twice with dioxane,Obtained pale yellow powdery solid 450g, yield 46.4percent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, and friends who are interested can also refer to it.