Schulte, James P. II; Tweedie, Scott R. published the artcile< Palladium-catalyzed couplings of heteroaryl amines with aryl halides using sodium phenolate as the stoichiometric base>, Category: pyrazoles-derivatives, the main research area is microwave mediated palladium catalyzed coupling heteroaryl amine aryl halide; pyrazole pyridine pyrazine isoxazole arylamino preparation.
Heteroaryl amines are efficiently coupled (in two hours) to aryl halides with catalytic Pd2(dba)3 and Xantphos to provide the corresponding biaryl amines under microwave and standard thermal conditions. E.g., 3-tert-butyl-1-methyl-1H-pyrazol-5-amine reacts with p-bromobenzonitrile in the presence of 1.25 mol% Pd2(dba)3, 3 mo% Xantphos ligand and 1,5 equivalent NaOPh/dioxane under microwave conditions to give 91% yield of biarylamine I. The use of organic-soluble Na phenolate (NaOPh) as the stoichiometric base promotes facile coupling of a variety of substrates in excellent yields.
Synlett published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaryl). 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Category: pyrazoles-derivatives.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics