Becica, Joseph; Hruszkewycz, Damian P.; Steves, Janelle E.; Elward, Jennifer M.; Leitch, David C.; Dobereiner, Graham E. published the artcile< High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides>, Computed Properties of 13788-92-6, the main research area is tertiary sulfonamide preparation palladium catalyst; secondary sulfonamide heteroaryl halide arylation high throughput screening.
Through targeted high-throughput experimentation (HTE), authors have identified the Pd/AdBippyPhos catalyst system as an effective and general method to construct densely functionalized N,N-diaryl sulfonamide motifs relevant to medicinal chem. AdBippyPhos is particularly effective for the installation of heteroaromatic groups. Computational steric parametrization of the investigated ligands reveals the potential importance of remote steric demand, where a large cone angle combined with an accessible Pd center is correlated to successful catalysts for C-N coupling reactions.
Organic Letters published new progress about Arenesulfonamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Computed Properties of 13788-92-6.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics