Hao, Zesheng; Wang, Weibo; Yu, Bin; Qi, Xin; Lv, You; Liu, Xiaoyu; Chen, Haoyin; Kalinina, Tatiana A.; Glukhareva, Tatiana V.; Fan, Zhijin published the artcile< Design, Synthesis, and Evaluation of Fungicidal Activity of Novel Pyrazole-Containing Strobilurin Derivatives>, Product Details of C11H19BN2O2, the main research area is pyrazole strobilurin preparation antifungal activity mol docking.
In searching for novel fungicidal leads, a series of pyrazole-containing strobilurins I (X = N, CH, R = OMe, methylamino, ethylamino, cyclopropylamino, R1 = Me, CHF2) and II were rationally designed, synthesized and characterized. Bioassays indicated that compound I (X = N, R = OMe, R1 = CHF2) (III) displayed excellent fungicidal activity against a broad spectrum of plant pathogens such as Gibberella zeae, Rhizoctonia cerealis, Sclerotinia sclerotiorum, Phytophthora infestans, Physalospora piricola and Pellicularia sasakii with EC50 of 0.16, 0.02, 0.72, 0.07, 0.77, and 0.65μg/mL, resp., which were 3-10 times more potent than the pos. control azoxystrobin against the corresponding pathogens. Moreover, like azoxystrobin and kresoxim-Me, III displayed excellent protective activity against P. sorghi. Mol. docking validated that III and azoxystrobin would share a similar binding mode with cytochrome bc1 complex. This study demonstrates that III is a promising fungicidal candidate for further development.
Chinese Journal of Chemistry published new progress about Acetamides Role: AGR (Agricultural Use), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 1046832-21-6 belongs to class pyrazoles-derivatives, and the molecular formula is C11H19BN2O2, Product Details of C11H19BN2O2.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics