Quality Control of 1,4,5,6-Tetrahydro-pyrrolo[3,4-c]pyrazole,hydrochloride《CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies》 was published in 2019. The authors were Fuller, Nathan O.;Pirone, Antonella;Lynch, Berkley A.;Hewitt, Michael C.;Quinton, Maria S.;McKee, Timothy D.;Ivarsson, Magnus, and the article was included in《ACS Chemical Neuroscience》. The author mentioned the following in the article:
Synaptic dysfunction is a pathol. feature in many neurodegenerative disorders, including Alzheimer’s disease, and synaptic loss correlates closely with cognitive decline. Histone deacetylases (HDACs) are involved in chromatin remodeling and gene expression and have been shown to regulate synaptogenesis and synaptic plasticity, thus providing an attractive drug discovery target for promoting synaptic growth and function. To date, HDAC inhibitor compounds with prosynaptic effects are plagued by known HDAC dose-limiting hematol. toxicities, precluding their application to treating chronic neurol. conditions. We have identified a series of novel HDAC inhibitor compounds that selectively inhibit the HDAC-co-repressor of repressor element-1 silencing transcription factor (CoREST) complex while minimizing hematol. side effects. HDAC1 and HDAC2 associate with multiple co-repressor complexes including CoREST, which regulates neuronal gene expression. We show that selectively targeting the CoREST co-repressor complex with the representative compound Rodin-A results in increased spine d. and synaptic proteins, and improved long-term potentiation in a mouse model at doses that provide a substantial safety margin that would enable chronic treatment. The CoREST-selective HDAC inhibitor Rodin-A(I) thus represents a promising therapeutic strategy in targeting synaptic pathol. involved in neurol. disorders. The experimental procedure involved many compounds, such as 1,4,5,6-Tetrahydro-pyrrolo[3,4-c]pyrazole,hydrochloride (cas: 157327-47-4) .
Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Quality Control of 1,4,5,6-Tetrahydro-pyrrolo[3,4-c]pyrazole,hydrochloride So, 1,4,5,6-Tetrahydro-pyrrolo[3,4-c]pyrazole,hydrochloride(cas: 157327-47-4) has been used in several drug studies
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics