Pyrazoles and pyrimidines have diverse biological and pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Reference of 761446-44-0.
Ji, Zhiqin;Clark, Richard F.;Bhat, Vikram;Matthew Hansen, T.;Lasko, Loren M.;Bromberg, Kenneth D.;Manaves, Vlasios;Algire, Mikkel;Martin, Ruth;Qiu, Wei;Torrent, Maricel;Jakob, Clarissa G.;Liu, Hong;Cole, Philip A.;Marmorstein, Ronen;Kesicki, Edward A.;Lai, Albert;Michaelides, Michael R. research published 《 Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases》, the research content is summarized as follows. P300 and CREB-binding protein (CBP) are essential for a multitude of cellular processes. Dysregulation of p300/CBP histone acetyltransferase activity is linked to a broad spectrum of human diseases including cancers. A novel drug-like spirohydantoin (21) has been discovered as a selective orally bioavailable inhibitor of p300/CBP histone acetyltransferase. Lead compound 21 is more potent than the first-in-class lead A-485 in both enzymic and cellular assays and lacks the off-target inhibition of dopamine and serotonin transporters, that was observed with A-485.
761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., Reference of 761446-44-0
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics