Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Recommanded Product: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole.
Huang, Chunhui;Fischer, Christian;Machacek, Michelle R.;Bogen, Stephane;Biftu, Tesfaye;Huang, Xianhai;Reutershan, Michael H.;Otte, Ryan;Hong, Qingmei;Wu, Zhicai;Yu, Yang;Park, Min;Chen, Lei;Biju, Purakkattle;Knemeyer, Ian;Lu, Ping;Kochansky, Christopher J.;Hicks, Michael Brendan;Liu, Yong;Helmy, Roy;Fradera, Xavier;Donofrio, Anthony;Close, Josh;Maddess, Matthew L.;White, Catherine;Sloman, David L.;Sciammetta, Nunzio;Lu, Jun;Gibeau, Craig;Simov, Vladimir;Zhang, Hongjun;Fuller, Peter;Witter, David research published 《 Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors》, the research content is summarized as follows. Efforts to reduce the electron-rich nature of the core were described. Ultimately, a strategy focused on core modifications to block metabolic hot spots coupled with substitution pattern changes (C8 N → C linked) led to the identification of new tricyclic analogs such as I (R1 = 1-aza-4-oxa[2.2.2]bicyclooctyl; R2 = trans-4-isopropoxycyclohexyl) with minimal GSH-adduct formation across species while maintaining an overall balanced profile.
Recommanded Product: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics