Some common heterocyclic compound, 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5952-92-1
[00263] Step A: (Trimethylsilyl)diazomethane (12.0 niL, 24 mmol, 2.0M solution in hexanes) was added dropwise via an addition funnel to a cold (O0C) solution of 1 -methyl- IH- pyrazole-4-carboxylic acid (0.59 g, 4.7 mmol) in MeOH (20 mL). The reaction mixture was stirred for 20 minutes and then concentrated. The crude product was partitioned between ethyl acetate (100 mL) and water (50 mL). The organics were dried, filtered and concentrated. The crude product was purified by flash chromatography, eluting with hexanes/ethyl acetate (4:1) to give methyl 1 -methyl- lH-pyrazole-4-carboxylate (0.50 g, 3.6 mmol, 76% yield) as a solid, m/z (APCI-pos) M+l = 141.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5952-92-1, its application will become more common.