Pyrazoles and pyrimidines have diverse biological and pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole.
Ghosh, Prithwish;Byun, Youjung;Kwon, Na Yeon;Kang, Ju Young;Mishra, Neeraj Kumar;Park, Jung Su;Kim, In Su research published 《 Reactivity of triplet diradical intermediates in aqueous media for transition-metal-free Csp2-H alkylation》, the research content is summarized as follows. Herein, a distinct reaction pathway involving triplet diradical intermediates in the coupling reaction between alkyl pyridinium ylides and electrophilic N-heterocyclic mols. was reported. Alkyl pyridinium ylides generated from alkyl pyridinium salts under basic aqueous conditions underwent addition into iminoamido N-heterocycles, generating triplet diradical intermediates lead to C-H alkylated N-heterocycles I [R = Me, Bn, 2-pyridyl, etc.; R1 = Br, Ph, 2-thienyl, etc.; R2 = Bn, CH2-2-FC6H4, CH2-2-naphthyl, etc.], II [R3 = Me, allyl, iPr, etc.; R4 = H, Cl; R5 = Bn, CH2-4-MeOC6H4, CH2-2-furyl, etc.; X = CH, N] and III [R6 = Me, 3-MeC6H4; R7 = Ph, Bn, 4-EtOC6H4, etc.]. The proposed reaction mechanism was supported by ESR and radical scavenging experiments Notably, a wide substrate scope and excellent level of functional group tolerance were attained under cost-effective and straightforward conditions, which revealed the amenability of this protocol in the pharmaceutical and chem. industries. These results were of significant relevance to the organic and medicinal chemists because of the handling simplicity, broad substrate scope, high efficiency, excellent chemoselectivity and the environmentally friendly conditions of the developed methodol.
Name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics