Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Quality Control of 761446-44-0.
Adlington, Neil K.;Agnew, Lauren R.;Campbell, Andrew D.;Cox, Robert J.;Dobson, Andrew;Barrat, Cristina Fernandez;Gall, Malcolm A. Y.;Hicks, William;Howell, Gareth P.;Jawor-Baczynska, Anna;Miller-Potucka, Lucie;Pilling, Michael;Shepherd, Katy;Tassone, Ross;Taylor, Brian A.;Williams, Aled research published 《 Process Design and Optimization in the Pharmaceutical Industry: A Suzuki-Miyaura Procedure for the Synthesis of Savolitinib》, the research content is summarized as follows. A process for the Suzuki-Miyaura coupling reaction on multihundred kilogram scale as the final step in the preparation of the potential antitumor agent savolitinib I is developed. The optimization of catalyst and solvent for the process, the kinetics of the Suzuki-Miyaura coupling, the dependence of byproduct formation on solvent, temperature, and catalyst loading, and the development of procedures for the removal of palladium residues from the product and for the recrystallization of the unsolvated product as the desired form I are discussed. The requirements for and constraints on the large scale preparation of an active pharmaceutical ingredient are discussed.
761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., Quality Control of 761446-44-0
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics