The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride( cas:22600-77-7 ) is researched.Computed Properties of C4H9Cl2N3.Casagrande, Manolo; Barteselli, Anna; Basilico, Nicoletta; Parapini, Silvia; Taramelli, Donatella; Sparatore, Anna published the article 《Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline》 about this compound( cas:22600-77-7 ) in Bioorganic & Medicinal Chemistry. Keywords: quinoline heteroarylmethylamino heteroarylamino preparation antiplasmodial activity; antimalarial aminoquinoline chloro preparation. Let’s learn more about this compound (cas:22600-77-7).
With the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-4-(heteroarylmethylamino)quinoline and 7-chloro-4-(heteroarylamino)quinoline derivatives was synthesized and tested in vitro against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum. All compounds exhibited from moderate to high antiplasmodial activities. The activity was strongly influenced both by the presence of a methylenic group, as a spacer between the 4-aminoquinoline and the heterocyclic ring, and by the presence of a basic head. The most potent mols. inhibited the growth of both CQ-S and CQ-R strains of P. falciparum with IC50 < 30 nM and were not toxic against human endothelial cells. These results confirm that the presence of an heteroaryl moiety in the side chain of 7-chloro-4-aminoquinoline is useful for the design and development of new powerful antimalarial agents. This compound((1H-Imidazol-2-yl)methanamine dihydrochloride)Computed Properties of C4H9Cl2N3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
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