Category: pyrazoles-derivatives. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Author is Ouvry, Gilles; Clary, Laurence; Tomas, Loic; Aurelly, Michele; Bonnary, Laetitia; Borde, Emilie; Bouix-Peter, Claire; Chantalat, Laurent; Defoin-Platel, Claire; Deret, Sophie; Forissier, Mathieu; Harris, Craig S.; Isabet, Tatiana; Lamy, Laurent; Luzy, Anne-Pascale; Pascau, Jonathan; Soulet, Catherine; Taddei, Alessandro; Taquet, Nathalie; Thoreau, Etienne; Varvier, Emeric; Vial, Emmanuel; Hennequin, Laurent F..
Minor structural modifications (sometimes single atom changes) can have a dramatic impact on the properties of compounds This is illustrated here on structures related to known mTOR inhibitor Sapanisertib. Subtle changes in the hinge binder lead to strikingly different overall profiles with changes in phys. properties, metabolism, and kinase selectivity.
This compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))Category: pyrazoles-derivatives was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics