So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Doguc, Duygu Kumbul; Deniz, Firdevs; Ilhan, Ilter; Ergonul, Esin; Gultekin, Fatih researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Synthetic Route of C18H14N2Na2O8S2.They published the article 《Prenatal exposure to artificial food colorings alters NMDA receptor subunit concentrations in rat hippocampus》 about this compound( cas:25956-17-6 ) in Nutritional Neuroscience. Keywords: hippocampus NMDA receptor erythrosine tartrazine amaranth; Artificial food colors; NMDARs; NR2A; NR2B; forced swim test; open field test; spatial learning and memory; α7 nAChR. We’ll tell you more about this compound (cas:25956-17-6).
Exposure to artificial food color additives (AFCAs) has been implicated in the etiol. of certain childhood hyperactivity and learning disabilities. N-methyl-D-aspartate receptors and alpha-7 nicotinic acetylcholine receptor (α7 nAChR) are involved in learning and memory. We administered a mixture of AFCAs (erythrosine, ponceau 4R, allura red AC, sunset yellow FCF, tartrazine, amaranth, brilliant blue, azorubine, and indigotine) to female rats during gestation to investigate the effects of prenatal exposure to AFCAs on neurobehavior, spatial learning, and memory in their offspring. We also investigated whether AFCAs modulate NR2A, NR2B, and α7 nAChR protein levels in their offsprings′ hippocampi. Although spatial learning and memory were not altered, the offspring of rats exposed to AFCAs exhibited decreased motivation and increased despair-related behavior. NR2A and NR2B protein levels were significantly reduced in female offspring in the exptl. group (p < 0.05), whereas α7 nAChR level was not significantly altered. Our results suggest that prenatal exposure to AFCAs may lead to sex-dependent alterations in glutamatergic signaling which may continue into adolescence. This compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate)Synthetic Route of C18H14N2Na2O8S2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics