So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Huang, Yaozeng; Liao, Yi researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Application of 17190-29-3.They published the article 《Synthetic applications of elementoorganic compounds of group 15 and 16. 85. Pentaalkyl stiboranes. 1. Synthesis of homobenzylic alcohols, homoallylic alcohols, homoallylic alcohols, ethyl 5-aryl-5-hydroxy-2-pentenoates, and β-hydroxypropionic acid derivatives via pentaalkylstiboranes》 about this compound( cas:17190-29-3 ) in Journal of Organic Chemistry. Keywords: stiborane alkyl preparation reaction aldehyde; alc homobenzylic homoallylic; pentenoate hydroxy; aldehyde aromatic reaction pentaalkylstiborane. We’ll tell you more about this compound (cas:17190-29-3).
Although pentaalkylstiboranes have long been known, their applications in organic synthesis have not been exploited. Treating [Bu3SbCH2E]+ X- (E = Ph, vinyl, CH:CHCO2Et, CO2Et, cyano; X = Br, iodo, BPh4) with RLi (R = Bu, Me3C, Ph) give pentaalkylstiboranes, Bu3Sb(R)CH2E, which react with aromatic aldehydes to give, after subsequent hydrolysis, homobenzylic and homoallylic alcs., Et 5-aryl-5-hydroxy-2-pentenoates, Et β-aryl-β-hydroxypropionates, and β-aryl-β-hydroxypropionitriles, resp., in good-to-excellent yields. The reaction is chemoselective for aldehydes.
This compound(3-Hydroxy-3-phenylpropanenitrile)Application of 17190-29-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics