Kawano, Yoshikazu; Kaneko, Nobuya; Mukaiyama, Teruaki published the article 《Lewis base-catalyzed cyanomethylation of carbonyl compounds with (trimethylsilyl)acetonitrile》. Keywords: Lewis base catalyzed cyanomethylation carbonyl compound trimethylsilyl acetonitrile; lithium acetate catalyzed cyanomethylation carbonyl compound silyl acetonitrile.They researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Category: pyrazoles-derivatives. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17190-29-3) here.
Catalytic cyanomethylation of various carbonyl compounds with (trimethylsilyl)acetonitrile (TMSCH2CN) in the presence of Lewis bases such as cesium or lithium acetate proceeded smoothly to afford the corresponding cyanomethylated adducts in good yields. Thus, AcOLi catalyzed cyanomethylation of PhCHO with Me3SiCH2CN in DMF at 0° to room temperature followed by acid hydrolysis gave 98% PhCHOHCH2CN.
《Lewis base-catalyzed cyanomethylation of carbonyl compounds with (trimethylsilyl)acetonitrile》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Category: pyrazoles-derivatives.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics