Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of the American Chemical Society called Pd/GF-Phos-Catalyzed Asymmetric Three-component Coupling Reaction to Access Chiral Diarylmethyl Alkynes, Author is Zhao, Guofeng; Wu, Yi; Wu, Hai-Hong; Yang, Junfeng; Zhang, Junliang, which mentions a compound: 52287-51-1, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2, Application of 52287-51-1.
Herein, a Pd-catalyzed enantioselective three-component coupling of N-tosylhydrazone, aryl halide and terminal alkyne under mild conditions utilizing a novel chiral sulfinamide phosphine ligand (GF-Phos), which provided a facile access to chiral diarylmethyl alkynes, the useful synthons in organic synthesis as well as exists as skeleton in many bioactive mols. was reported. A pair of enantiomers of the product could be easily prepared using the same chiral ligand by simply changing the aryl substituents of the N-tosylhydrazone, aryl halide. The salient features of this reaction included the readily available starting materials, general substrate scope, high enantioselectivity, ease of scale up, mild reaction conditions and versatile transformations.
《Pd/GF-Phos-Catalyzed Asymmetric Three-component Coupling Reaction to Access Chiral Diarylmethyl Alkynes》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine)Application of 52287-51-1.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics