Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1300746-79-5, is researched, SMILESS is F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F, Molecular C13H8CuF3N2Journal, Article, European Journal of Medicinal Chemistry called Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine “”bio-oxidizable”” prodrugs: Synthesis, biological evaluation and structure-activity relationship, Author is Azzouz, Rabah; Peauger, Ludovic; Gembus, Vincent; Tintas, Mihaela-Liliana; Sopkova-de Oliveira Santos, Jana; Papamicael, Cyril; Levacher, Vincent, the main research direction is benzylpyridinium salt dihydropyridine preparation antialzheimer mol docking; AChEIs; Alzheimer; Donepezil analogues; “Bio-oxidizable” prodrug.Category: pyrazoles-derivatives.
A total of fifty one N-benzylpyridinium quaternary donepezil analogs B1-3 I [R = Ph, 2,3-dihydro-1,3-benzoxazol-2-yl, cyclohexyl, etc.; R1 = H, F, OH, OCH3; R2 = H, OCH3; R1, R2 = -OCH2O-; EWG = H, CN, CF3, C(O)NH2, etc.; X = Br, I; n = 0, 1, 2] and twenty two prodrugs A1-3 II was synthesized and evaluated for their inhibitory activities against hAChE and eqBuChE. While most prodrugs A1-3 were demonstrated to be inactive against AChE (IC50 >10 μM), a large number of the corresponding N-benzylpyridinium salt B1-3 exhibited appealing three-to-one-digit nanomolar hAChE inhibitory activities and even reaching subnanomolar activity (IC50 = 0.36 nM). In addition, in silico docking studies were conducted for several compounds to explain the more relevant in vitro results. Lastly, the influence of the two stereogenic centers in prodrugs A was also evaluated, highlighting not only marked differences in residual AChE inhibitory activity of the four separated isomers of prodrug II [R = 3-chlorophenyl; R1 = H, F, OH, OCH3; R2 = OCH3; EWG = C(O)NH2;n = 1] (IC50 ranging from 173 nM to 10 μM) but also significant variations of the oxidation rate between two separated diastereoisomers of prodrug II [R = phenyl; R1 = R2 = OCH3; EWG = C(O)CH3; n = 2]. This work provides useful information in the search of a preclin. candidate to conduct further development of this attractive “”bio-oxidizable”” prodrug strategy.
Different reactions of this compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))Category: pyrazoles-derivatives require different conditions, so the reaction conditions are very important.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics