Category: pyrazoles-derivatives. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Addition of α-Halo-substituted Carbonitriles to Aldehydes and Ketones in the Presence of Iron Pentacarbonyl.
Halo-substituted carbonitriles in the presence of iron pentacarbonyl react with aldehydes and ketones by Reformatsky reaction type. In contract to halo-substituted esters the nitriles are considerably more reactive toward ketones than aldehydes. At the same time the structure and yield of products obtained from both nitriles and esters are strongly and similarly affected by the character of the para-substituents in the benzaldehyde. Thus, Fe(CO)5-mediated reaction of ICH2CN with 2-hexanone in C6H6 gave 70% 3-hydroxy-3-methylenanthonitrile.
After consulting a lot of data, we found that this compound(17190-29-3)Category: pyrazoles-derivatives can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics