The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Fluoro-1H-indole-3-carboxylic acid, is researched, Molecular C9H6FNO2, CAS is 23077-42-1, about Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties, the main research direction is antimycobacterial membrane targeting indole preparation structure activity.Formula: C9H6FNO2.
Antibacterials that disrupt cell membrane function have the potential to eradicate “”persister”” organisms and delay the emergence of resistance. Here we report the antimycobacterial activities of 4-fluoro and 6-methoxyindoles bearing a cationic amphiphilic motif represented by a lipophilic n-octyl side chain at position 1 and a pos. charged azepanyl or 1,4-dioxa-8-azaspiro[4.5]decane moiety at position 3. These analogs exhibited balanced profiles of potency (Mycobacterium bovis BCG, M tuberculosis H37Rv), selective activity, solubility, and metabolic stability. Bacteriol. mechanism of action investigations on a representative analog revealed cell membrane permeabilization and depolarization in M bovis BCG. These membrane-related changes preceded cell death indicating that the loss in membrane integrity was not an epiphenomenon. Bactericidal activity was observed against both growing and nongrowing mycobacterial cultures. The analog also upregulated cell envelope stress-inducible promoters piniBAC and pclgR, implicating the involvement of envelope-related targets in its mode of action.
After consulting a lot of data, we found that this compound(23077-42-1)Formula: C9H6FNO2 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics