Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Catalytic cyanomethylation of carbonyl compounds and imines with highly basic phosphine.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.
A highly basic phosphine, [2,4,6-(MeO)3C6H2]3P (TTMPP), catalyzes cyanomethylation using Me3SiCH2CN (TMSCH2CN) to give the corresponding products in good to high yields, with both carbonyl compounds and imines.
After consulting a lot of data, we found that this compound(17190-29-3)Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics