The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Formula: C9H9NO.Talwar, Dinesh; Wu, Xiaofeng; Saidi, Ourida; Salguero, Noemi Poyatos; Xiao, Jianliang published the article 《Versatile Iridicycle Catalysts for Highly Efficient and Chemoselective Transfer Hydrogenation of Carbonyl Compounds in Water》 about this compound( cas:17190-29-3 ) in Chemistry – A European Journal. Keywords: iridium transfer hydrogenation reduction carbonyl compound; carbonyl groups; cyclometalated complexes; iridium; transfer hydrogenation; water. Let’s learn more about this compound (cas:17190-29-3).
Cyclometalated iridium complexes are shown to be highly efficient and chemoselective catalysts for the transfer hydrogenation of a wide range of carbonyl groups with formic acid in water. Examples include α-substituted ketones (α-ether, α-halo, α-hydroxy, α-amino, α-nitrile or α-ester), α-keto esters, β-keto esters and α,β-unsaturated aldehydes. The reduction was carried out at substrate/catalyst ratios of up to 50 000 at pH 4.5 and required no organic solvent. The protocol provides a practical, easy and efficient way for the synthesis of β-functionalized secondary alcs., such as β-hydroxy-ethers, β-hydroxy-amines and β-hydroxyhalo compounds, which are valuable intermediates in pharmaceutical, fine chem., perfume and agrochem. synthesis. Under optimized conditions the synthesis of the target compounds was achieved using chloro[3-[1-[(4-methoxyphenyl)imino-κN]ethyl]-2-naphthalenyl-κC][(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]iridium (naphthalene-imine complex) and chloro[2-[1-[(4-methoxyphenyl)imino-κN]ethyl]-3-phenanthrenyl-κC][(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]iridium (phenanthrene-imine complex) as catalysts. The title compounds thus formed included α-[(4-chlorophenoxy)methyl]benzenemethanol α-[(3-pyridinyloxy)methyl]benzenemethanol, 1-phenoxy-2-propanol, 2-(ethoxy)cyclohexanol (ether-alc.), 1,4-anhydro-2,5-dideoxypentitol (carbohydrate sugar derivative), α-(chloromethyl)benzenemethanol, β-(hydroxy)benzenepropanenitrile, β-(hydroxy)thiophenepropanenitrile (thiophene derivative), β-(hydroxy)furanpropanenitrile (furan derivative), 1-phenyl-1,2-ethanediol benzoate and related substances, piperidine derivatives, morpholine derivatives, pyridine derivatives
Although many compounds look similar to this compound(17190-29-3)Formula: C9H9NO, numerous studies have shown that this compound(SMILES:N#CCC(O)C1=CC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics