Archives for Chemistry Experiments of 23077-42-1

Although many compounds look similar to this compound(23077-42-1)Quality Control of 4-Fluoro-1H-indole-3-carboxylic acid, numerous studies have shown that this compound(SMILES:O=C(C1=CNC2=C1C(F)=CC=C2)O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Quality Control of 4-Fluoro-1H-indole-3-carboxylic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Fluoro-1H-indole-3-carboxylic acid, is researched, Molecular C9H6FNO2, CAS is 23077-42-1, about Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles. Author is Dallagnol, Juliana C. C.; Khajehali, Elham; van der Westhuizen, Emma T.; Jorg, Manuela; Valant, Celine; Goncalves, Alan G.; Capuano, Ben; Christopoulos, Arthur; Scammells, Peter J..

Targeting allosteric sites at M1 muscarinic acetylcholine receptors is a promising strategy for the treatment of Alzheimer’s disease. Pos. allosteric modulators not only may potentiate binding and/or signaling of the endogenous agonist acetylcholine (ACh) but also may possess direct agonist activity (thus referred to as PAM-agonists). Recent studies suggest that PAM-agonists with robust intrinsic efficacy are more likely to produce adverse effects in vivo. Herein we present the synthesis and pharmacol. evaluation of a series of pyrrole-3-carboxamides with a diverse range of allosteric profiles. We proposed structural modifications at top, core, or pendant moieties of a prototypical mol. Although generally there was a correlation between the degree of agonist activity and the modulatory potency of the PAMs, some derivatives displayed weak intrinsic efficacy yet maintained strong allosteric modulation. We also identified mols. with the ability to potentiate mainly the affinity or both affinity and efficacy of ACh.

Although many compounds look similar to this compound(23077-42-1)Quality Control of 4-Fluoro-1H-indole-3-carboxylic acid, numerous studies have shown that this compound(SMILES:O=C(C1=CNC2=C1C(F)=CC=C2)O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics