The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.COA of Formula: C9H9NO.Yang, Zhiheng; Cheng, Weiyan; Li, Zeyun published the article 《Iridium catalysed highly efficient transfer hydrogenation reduction of aldehydes and ketones in water》 about this compound( cas:17190-29-3 ) in Catalysis Communications. Keywords: alc preparation; aldehyde iridium catalyst transfer hydrogenation; ketone iridium catalyst transfer hydrogenation. Let’s learn more about this compound (cas:17190-29-3).
A new transfer hydrogenation of structurally diverse aldehydes and ketones in water using formic acid as hydride donor was developed, to get the corresponding alcs. The iridium complex of 4,4′,5,5′-tetrahydro-1H,1’H-2,2′-biimidazole, was used as an efficient catalyst. The S/C ratios in aldehyde and ketone reductions were as low as 20,000 and 10,000 resp. The TOF value in aldehyde reduction was as high as 60,000 h-1. A number of functional groups such as (hetero)aryl, alkenyl, halogen, phenolic and alc. hydroxyls, trifluromethyl, cyano, nitro, ester, carboxylic acid and acidic methylenes were well tolerated.
As far as I know, this compound(17190-29-3)COA of Formula: C9H9NO can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics