The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Recommanded Product: 17190-29-3.Jinzaki, Takaaki; Arakawa, Mitsuru; Kinoshita, Hidenori; Ichikawa, Junji; Miura, Katsukiyo published the article 《Nucleophilic Addition of α-(Dimethylsilyl)nitriles to Aldehydes and Ketones》 about this compound( cas:17190-29-3 ) in Organic Letters. Keywords: beta hydroxynitrile preparation alpha dimethylsilylnitrile aldehyde ketone nucleophilic addition; nucleophilic addition dimethylsilylnitrile metal salt promoter catalyst. Let’s learn more about this compound (cas:17190-29-3).
α-Alkylated (dimethylsilyl)acetonitriles (Me2HSiCR3R4CN) react spontaneously with aldehydes in DMSO to give β-hydroxynitriles in good to high yields. The addition to ketones is effectively promoted by using MgCl2 or CaCl2. (Dimethylsilyl)acetonitrile (Me2HSiCH2CN) shows lower reactivity than the α-alkylated analogs. However, the parent reagent adds efficiently to aldehydes and ketones under catalysis by AcOLi or MgCl2.
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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics