The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine(SMILESS: BrC1=CC=C2OCCOC2=C1,cas:52287-51-1) is researched.Synthetic Route of C4H6O4Pd. The article 《Synthesis of Axially Chiral 2,2′-Bisphosphobiarenes via a Nickel-Catalyzed Asymmetric Ullmann Coupling: General Access to Privileged Chiral Ligands without Optical Resolution》 in relation to this compound, is published in Journal of the American Chemical Society. Let’s take a look at the latest research on this compound (cas:52287-51-1).
The authors report an asym. homocoupling of ortho-(iodo)arylphosphine oxides and ortho-(iodo)arylphosphonates resulting in highly enantioenriched axially chiral bisphosphine oxides and bisphosphonates. These products are readily converted to enantioenriched biaryl bisphosphines without need for chiral auxiliaries or optical resolution This provides a practical route for the development of previously unstudied atroposelective biaryl bisphosphine ligands. The conditions also proved effective for asym. dimerization of other, nonphosphorus-containing aryl halides.
I hope my short article helps more people learn about this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine)COA of Formula: C8H7BrO2. Apart from the compound(52287-51-1), you can read my other articles to know other related compounds.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics