The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Hydroxy-3-phenylpropanenitrile(SMILESS: N#CCC(O)C1=CC=CC=C1,cas:17190-29-3) is researched.Related Products of 814-94-8. The article 《Ionization of an α-hydrogen of acetonitrile by n-butyllithium and alkali amides. Condensations with ketones and aldehydes to form β-hydroxynitriles》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:17190-29-3).
MeCN underwent mainly ionization of an α-H with BuLi in tetrahydrofuran-hexane, rather than an addition reaction involving the CN group. The former course of reaction was evidenced by an addition of the resulting lithioacetonitrile to benzophenone (I), to form 89% 3-hydroxy-3,3-diphenylpropanonitrile. Similarly, an α-H of MeCN was ionized by Na, Li, and K amides in liquid NH3 and the resulting alkali acetonitrile condensed with I to give this β-hydroxynitrile in 93, 85, and 69% yields, resp. The BuLi method was extended to several other ketones and to BzH. These results illustrate convenient methods for the synthesis of such β-hydroxynitriles, which can be dehydrated with acid to form the corresponding unsaturated nitriles. 26 references.
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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics