The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1 ) is researched.Synthetic Route of C8H7BrO2.Dauksas, V.; Udrenaite, E. published the article 《Anomalous nitration reactions of 1,4-benzodioxan derivatives》 about this compound( cas:52287-51-1 ) in Lietuvos TSR Aukstuju Mokyklu Mokslo Darbai, Chemija ir Chemine Technologija. Keywords: benzodioxan nitration. Let’s learn more about this compound (cas:52287-51-1).
Dinitrobenzodioxan (I, R = Et, R1 = R2 = NO2) was obtained in 90% yield by nitration of I (R = Et, R1 = NO2, R2 = H) with 75% HNO3 2 hr at 25°. Oxidation of I (R = COMe, R1 = Br, R2 = H) gave 99% I (R = CO2H, R1 = Br, R2 = H) which was nitrated with 75% HNO3 6 hr at 90° to give 46% I (R = NO2, R1 = Br, R2 = H). Analogously obtained was 41% I (R = R1 = NO2, R2 = H) and 30% I (R = COCH2NO2, R1 = NO2, R2 = H). Nitration of I (R = R1 = H, R2 = NO2) gave a mixture containing I (R = H, R1 = R2 = NO2), I (R = R2 = NO2, R1 = H), and 5,8-dinitro-1,4-benzodioxan.
Compound(52287-51-1)Synthetic Route of C8H7BrO2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine), if you are interested, you can check out my other related articles.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics