So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yang, Sabyuk; Hong, Soon Hyeok researched the compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1 ).Computed Properties of C8H7BrO2.They published the article 《Palladium-Catalyzed Direct C-H Arylation of Arenes Promoted by Quaternary Ammonium Salt》 about this compound( cas:52287-51-1 ) in Asian Journal of Organic Chemistry. Keywords: biaryl preparation regioselective; arene aryl bromide arylation palladium catalyzed. We’ll tell you more about this compound (cas:52287-51-1).
A new Pd-based catalytic system for the direct C-H arylation of arenes was developed. The use of a substoichiometric amount of quaternary ammonium salt as an additive with a Pd source achieved the direct arylation of unactivated arenes under milder reaction conditions in moderate to high yields. The ammonium salt generated the anionic palladium complex, thereby facilitating arylation by a concerted metalation-deprotonation process.
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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics