Pamies, Oscar; Backvall, Jan-E. published the article 《Efficient lipase-catalyzed kinetic resolution and dynamic kinetic resolution of β-hydroxy nitriles. Correction of absolute configuration and transformation to chiral β-hydroxy acids and γ-amino alcohols》. Keywords: kinetic enzymic resolution hydroxy nitrile transacetylation; hydroxy carboxylic acid stereoselective preparation enzymic resolution; amino alc stereoselective preparation enzymic resolution.They researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).SDS of cas: 17190-29-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17190-29-3) here.
Chemoenzymic dynamic kinetic resolution of β-hydroxy nitriles has been carried out using Candida antarctica lipase B and a ruthenium catalyst. The use of a hydrogen source to depress ketone formation in the dynamic kinetic resolution yields the acetates in good yield and high enantioselectivity. It is shown that the ruthenium catalyst and the enzyme can be recycled when used in sep. reactions. Enantiomerically pure β-hydroxy acid derivatives and γ-amino alcs. were prepared from the hydroxy nitriles and acetates. The latter compounds were also used to establish the correct absolute configuration of the hydroxy nitriles and acetates.
In some applications, this compound(17190-29-3)SDS of cas: 17190-29-3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics